Nav1.6 sodium channel model in globus pallidus neurons (Mercer et al. 2007)

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Accession:105385
Model files for the paper Mercer JN, Chan CS, Tkatch T, Held J, Surmeier DJ. Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons.,J Neurosci. 2007 Dec 5;27(49):13552-66.
Reference:
1 . Mercer JN, Chan CS, Tkatch T, Held J, Surmeier DJ (2007) Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons. J Neurosci 27:13552-66 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Globus pallidus neuron;
Channel(s): I Na,p; I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.6 SCN8A;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Action Potentials; Parkinson's;
Implementer(s): Held, Joshua [j-held at northwestern.edu];
Search NeuronDB for information about:  I Na,p; I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
NEURON {
	SUFFIX sk_gp
	USEION k READ ek WRITE ik
        USEION ca READ cai
        RANGE  gbar,gkahp,ik
        GLOBAL inf,tau
	GLOBAL Cq10
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(molar) = (1/liter)
	(mM) = (millimolar)
	(S) = (siemens)
}

PARAMETER {
	gbar = 1	(S/cm2)
        n = 4
        cai = 50.e-6	(mM)
        a0 = 1.3e13	(1/ms-mM-mM-mM-mM)	:b0/(1.4e-4^4)
        b0 = .5e-2	(1/ms)			:0.5/(0.100e3)
	        celsius (degC)
	Cq10 = 3
}

STATE {	w }

ASSIGNED {
	ik	(mA/cm2)
        g	(S/cm2)
        inf
        tau	(ms)
	a	(1/ms)
        v	(mV)
        ek	(mV)
}

BREAKPOINT {
	SOLVE state METHOD cnexp
	g = gbar*w
	ik = g*(v-ek)
}

INITIAL {
	rate(cai)
	w=inf
}

DERIVATIVE state {
	rate(cai)
	w' = (inf - w)/tau
}

PROCEDURE rate(cai (mM)) {
	LOCAL q10:, cai_eff
	:if (cai<1e-12) {
	:	cai_eff = 1e-12
	:} else {
	:	cai_eff = cai
	:}
	q10 = Cq10^((celsius - 22 (degC))/10 (degC) )
	a = a0*cai^4
	:a = a0*cai_eff^4
	tau = q10/(a + b0)
	inf = a/(a + b0)
}

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