Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)

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Accession:112834
"We describe a computational model of the principal cell in the nucleus accumbens (NAcb), the medium spiny projection (MSP) neuron. The model neuron, constructed in NEURON, includes all of the known ionic currents in these cells and receives synaptic input from simulated spike trains via NMDA, AMPA, and GABAA receptors. ... results suggest that afferent information integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is altered or modulated, as has been proposed in both schizophrenia and addiction."
Reference:
1 . Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neurosci 25:9080-95 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Nucleus accumbens spiny projection neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Schizophrenia; Addiction;
Implementer(s): Wolf, John A. [johnwolf at warpmail.net]; Moyer, Jason [jtmoyer at seas.upenn.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
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nacb_msp
tau_tables
readme.html
AMPA.mod
bkkca.mod *
cadyn.mod *
caL.mod *
caL13.mod *
caldyn.mod
can.mod *
caq.mod *
car.mod *
cat.mod *
GABA.mod *
kaf.mod *
kas.mod *
kir.mod *
krp.mod *
naf.mod *
nap.mod *
NMDA.mod
skkca.mod *
stim.mod *
_run_me.hoc
all_tau_vecs.hoc *
baseline_values.txt *
basic_procs.hoc
create_mspcells.hoc *
current_clamp.ses *
make_netstims.hoc
mosinit.hoc *
msp_template.hoc
nacb_main.hoc
netstims_template.hoc *
screenshot.jpg
screenshot2.jpg
stimxout_jns_sqwave.dat
synapse_templates.hoc
                            
//****************************************************************************
// These are the default parameters for creation of the MSP cell.  This file
// is usually called by hoc/nacb_main.hoc

cai0_ca_ion = 0.001		// mM, Churchill 1998
cao0_ca_ion = 5			// mM, Churchill 1998 - gives eca = 100 mV
cali0_cal_ion = 0.001		// mM, Churchill 1998
calo0_cal_ion = 5			// mM, Churchill 1998 - gives eca = 100 mV
celsius = 35			// degC

global_ra = 100		// not really sure what this is
RA = 100			// ohm-cm - constant for whole cell
CM = 1				// uF-cm2 - constant for whole cell
G_PAS = 1.15e-5			// S/cm2
E_PAS = -70			// mV

G_NAF = 1.5		// soma only
G_NAFD = 0.0195	// all dends
G_NAP = 4e-5		// soma only
G_NAPD = 1.3802e-7	// all dends

G_KIR = 0.00014		// S/cm2
G_KAS = 0.0104		// soma & prox dends; s/cm2
G_KASD = 0.00095142	// mid & distal dends; S/cm2
G_KAF = 0.225 		// soma & prox dends; S/cm2
G_KAFD = 0.020584	// mid & dist dends; S/cm2
G_KRP = 0.001 		// 0.004; S/cm2
G_BKKCA = 0.001		// 
G_SKKCA = 0.145

CAINF = 1e-5			// mM, steady state intracell ca conc.
TAUR = 43			// ms, time const of ca diffusion - Jackson 2003
CA_DRIVE = 10000
CA_PUMP = 0.02

caNMDA = 0.1
P_CAL = 6.7e-6			// cm/s
P_CALD = 6.7e-6			// cm/s
P_CAL13 = 4.25e-7		//1.7e-6		// cm/s
P_CAL13D = 4.25e-7		//1.7e-6		// cm/s
P_CAN = 1.0e-5			// cm/s
P_CAQ = 6.0e-6			// cm/s
P_CAR = 2.6e-5			// cm/s
P_CAT = 4e-7			// cm/s	4e-7

EK = -90
ENA = 50

NET_N = 1e10

G_AMPA = 8.5e-4		//350e-6		//8.81e-4
G_NMDA = 12.2e-5	// 9.2e-5	
G_GABA = 0.0021		//4300e-6	//0.0027

AMPA_WT = 1
NMDA_WT = 1
GABA_WT = 1

NOISE = 1

NGLU = 84
NGABA = 84
NSYN = NGABA + NGLU
//****************************************************************************


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