Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)

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Accession:112834
"We describe a computational model of the principal cell in the nucleus accumbens (NAcb), the medium spiny projection (MSP) neuron. The model neuron, constructed in NEURON, includes all of the known ionic currents in these cells and receives synaptic input from simulated spike trains via NMDA, AMPA, and GABAA receptors. ... results suggest that afferent information integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is altered or modulated, as has been proposed in both schizophrenia and addiction."
Reference:
1 . Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neurosci 25:9080-95 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Nucleus accumbens spiny projection neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Schizophrenia; Addiction;
Implementer(s): Wolf, John A. [johnwolf at warpmail.net]; Moyer, Jason [jtmoyer at seas.upenn.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
/
nacb_msp
tau_tables
readme.html
AMPA.mod
bkkca.mod *
cadyn.mod *
caL.mod *
caL13.mod *
caldyn.mod
can.mod *
caq.mod *
car.mod *
cat.mod *
GABA.mod *
kaf.mod *
kas.mod *
kir.mod *
krp.mod *
naf.mod *
nap.mod *
NMDA.mod
skkca.mod *
stim.mod *
_run_me.hoc
all_tau_vecs.hoc *
baseline_values.txt *
basic_procs.hoc
create_mspcells.hoc *
current_clamp.ses *
make_netstims.hoc
mosinit.hoc *
msp_template.hoc
nacb_main.hoc
netstims_template.hoc *
screenshot.jpg
screenshot2.jpg
stimxout_jns_sqwave.dat
synapse_templates.hoc
                            
/* This is the primary file for creating the MSP cell - this file calls all
	of the hoc files necessary to build one cell and sets the default
	parameter values.
	
	Usually this file is called by a hoc file in /input_params/.
	
	Jason Moyer 2005 - jtmoyer@seas.upenn.edu
*/
	

//****************************************************************************
//Load all the baseline parameters to start with

sprint(dirstr, "%s/baseline_values.txt", preface)
//print dirstr
xopen(dirstr)
//load_file("../input_params/baseline_values.txt")
//****************************************************************************



//****************************************************************************
// all_tau_vecs.hoc loads the tables used to define the taus for many channels

sprint(dirstr, "%s/all_tau_vecs.hoc", preface)
//print dirstr
xopen(dirstr)
//load_file("all_tau_vecs.hoc")
//****************************************************************************



//****************************************************************************
//load the templates for the synapses - AMPA, GABA, and NMDA

sprint(dirstr, "%s/synapse_templates.hoc", preface)
xopen(dirstr)
//load_file("synapse_templates.hoc")
//****************************************************************************




//****************************************************************************
// load cell template - builds the cell topology, including inserting
// channels and synapses; dlambda code is in here (under geom()) along 
// with code to output the number of compartments in cell

sprint(dirstr, "%s/msp_template.hoc", preface)
xopen(dirstr)
//load_file ("msp_template.hoc")
//****************************************************************************



create acell_home_



//****************************************************************************
// load netstims template, sets default interval, number, noise

sprint(dirstr, "%s/netstims_template.hoc", preface)
xopen(dirstr)
//load_file("netstims_template.hoc")
//****************************************************************************



//****************************************************************************
// create msp cells using cell_append(), nc_append()
// set number of segments using geom_nseg() (in fixnseg.hoc)
// create shunt for sharp electrode

sprint(dirstr, "%s/create_mspcells.hoc", preface)
xopen(dirstr)
//load_file("create_mspcells.hoc")
//****************************************************************************





//**********************************************************************
// calculate membrane area, access soma by default
A1 = 0
Ad = 0

forsec "dend._.*" {
	for i = 1, nseg {
		Ad = Ad + area( i/(nseg+1) )
	}
}

forsec "MSP_Cell[0]"  {
	for i = 1, nseg {
		A1 = A1 + area( i/(nseg+1) )
	}
}

Ap = A1 - Ad

print "Total cell membrane area = ", A1		// equals whole cell membrane area
print "Mid + Dist mem area = ", Ad
print "Soma + Prox mem area = ", Ap 

//**********************************************************************





//****************************************************************************
// specify cell's active properties using constants listed in
// input_params/baseline_values.txt
//

sprint(dirstr, "%s/basic_procs.hoc", preface)
xopen(dirstr)

set_pas(G_PAS)

set_naf(G_NAF)
set_nafd(G_NAFD)
set_nap(G_NAP)
set_napd(G_NAPD)

set_kir(G_KIR)
set_kas(G_KAS)
set_kasd(G_KASD)
set_kaf(G_KAF)
set_kafd(G_KAFD)
set_krp(G_KRP)
set_bkkca(G_BKKCA)
set_skkca(G_SKKCA)

set_caL(P_CAL)
set_caL13(P_CAL13)
set_can(P_CAN)
set_caq(P_CAQ)
set_car(P_CAR)
set_cat(P_CAT)

set_cainf(CAINF)
set_taur(TAUR)
set_cadrive(CA_DRIVE)
set_pump(CA_PUMP)

set_ek(EK)
forsec "MSP_Cell" {Ra = RA    cm = CM}

//****************************************************************************




//*************************************************************************
// create and set netstims using champawt(), chnmdawt(), chint()

sprint(dirstr, "%s/make_netstims.hoc", preface)
xopen(dirstr)

//*************************************************************************



access MSP_Cell[0].soma





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