Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)

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Accession:112834
"We describe a computational model of the principal cell in the nucleus accumbens (NAcb), the medium spiny projection (MSP) neuron. The model neuron, constructed in NEURON, includes all of the known ionic currents in these cells and receives synaptic input from simulated spike trains via NMDA, AMPA, and GABAA receptors. ... results suggest that afferent information integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is altered or modulated, as has been proposed in both schizophrenia and addiction."
Reference:
1 . Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neurosci 25:9080-95 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Nucleus accumbens spiny projection neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Schizophrenia; Addiction;
Implementer(s): Wolf, John A. [johnwolf at warpmail.net]; Moyer, Jason [jtmoyer at seas.upenn.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
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nacb_msp
tau_tables
readme.html
AMPA.mod
bkkca.mod *
cadyn.mod *
caL.mod *
caL13.mod *
caldyn.mod
can.mod *
caq.mod *
car.mod *
cat.mod *
GABA.mod *
kaf.mod *
kas.mod *
kir.mod *
krp.mod *
naf.mod *
nap.mod *
NMDA.mod
skkca.mod *
stim.mod *
_run_me.hoc
all_tau_vecs.hoc *
baseline_values.txt *
basic_procs.hoc
create_mspcells.hoc *
current_clamp.ses *
make_netstims.hoc
mosinit.hoc *
msp_template.hoc
nacb_main.hoc
netstims_template.hoc *
screenshot.jpg
screenshot2.jpg
stimxout_jns_sqwave.dat
synapse_templates.hoc
                            
TITLE Fast A-type Potassium current for nucleus accumbens (Kv4.2)

COMMENT
Jason Moyer 2004 - jtmoyer@seas.upenn.edu

Tkatch, T., Baranauskas, G., and Surmeier, D. J. (2000). Kv4.2 mRNA
abundance and A-type K(+) current amplitude are linearly related in
basal ganglia and basal forebrain neurons. J Neurosci 20, 579-588.

22 degrees

ENDCOMMENT

UNITS {
	(mV) = (millivolt)
	(mA) = (milliamp)
	(S) = (siemens)
}

NEURON {
	SUFFIX kaf
	USEION k READ ek WRITE ik
	RANGE gkbar, ik, mshift, hshift
}

PARAMETER {
	gkbar = 0.21	(S/cm2)		: 0.21 in soma and prox; 0.019211 in mid/dist dends

	mvhalf = -10.0	(mV)		: Tkatch 2000 pg 581
	mslope = -17.7	(mV)		: Tkatch 2000 pg 581 - need to use -17.7, not 17.7
	mshift = 0	(mV)
	
	hvhalf = -75.6	(mV)		: Tkatch 2000 pg 582
	hslope	= 10	(mV)		: match to Tkatch 2000 fig 3B
	hshift = 0	(mV)
	htau = 14	(ms)			: Tkatch 2000 Fig 3C

	qfact = 3
	power = 2
}

ASSIGNED { 
	v 		(mV)
    ik 		(mA/cm2)
	ek 		(mV)

	minf
	hinf
}

STATE {
    m h
}

BREAKPOINT {
    SOLVE states METHOD cnexp
	ik  = gkbar * m^power * h * (v-ek)
}

INITIAL {
	rates(v)
	m = minf
	h = hinf
}

FUNCTION_TABLE mtau (v(mV))  (ms)	: Tkatch 2000 Fig 2B

DERIVATIVE states {  
	rates(v)
	m' = (minf - m) / (mtau(v) / qfact)
	h' = (hinf - h) / (htau / qfact)
}


PROCEDURE rates( v(mV) ) {  : Boltzman adjusted to give proper Erev dependency 
	TABLE minf, hinf DEPEND mshift, hshift, hslope
		FROM -200 TO 200 WITH 201
			minf = 1  /  ( 1 + exp( (v - mvhalf - mshift) / mslope) ) 
			hinf = 1  /  ( 1 + exp( (v - hvhalf - hshift) / hslope) ) 
}



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