Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)

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Accession:112834
"We describe a computational model of the principal cell in the nucleus accumbens (NAcb), the medium spiny projection (MSP) neuron. The model neuron, constructed in NEURON, includes all of the known ionic currents in these cells and receives synaptic input from simulated spike trains via NMDA, AMPA, and GABAA receptors. ... results suggest that afferent information integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is altered or modulated, as has been proposed in both schizophrenia and addiction."
Reference:
1 . Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neurosci 25:9080-95 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Nucleus accumbens spiny projection neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Schizophrenia; Addiction;
Implementer(s): Wolf, John A. [johnwolf at warpmail.net]; Moyer, Jason [jtmoyer at seas.upenn.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
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nacb_msp
tau_tables
readme.html
AMPA.mod
bkkca.mod *
cadyn.mod *
caL.mod *
caL13.mod *
caldyn.mod
can.mod *
caq.mod *
car.mod *
cat.mod *
GABA.mod *
kaf.mod *
kas.mod *
kir.mod *
krp.mod *
naf.mod *
nap.mod *
NMDA.mod
skkca.mod *
stim.mod *
_run_me.hoc
all_tau_vecs.hoc *
baseline_values.txt *
basic_procs.hoc
create_mspcells.hoc *
current_clamp.ses *
make_netstims.hoc
mosinit.hoc *
msp_template.hoc
nacb_main.hoc
netstims_template.hoc *
screenshot.jpg
screenshot2.jpg
stimxout_jns_sqwave.dat
synapse_templates.hoc
                            
TITLE Krp (4ap resistant, persistent) current for nucleus accumbens

COMMENT

Nisenbaum ES, Wilson CJ, Foehring RC, Surmeier DJ (1996). Isolation and
characterization of a persistent potassium current in neostriatal neurons. J
Neurophys 76(2): 1180-1194.

Recorded at 22C - corrected to 35C with qfact 3

Jason Moyer 2004 - jtmoyer@seas.upenn.edu

ENDCOMMENT

UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
        (S)  = (siemens)
}
 
NEURON {
        SUFFIX krp
        USEION k READ ek WRITE ik
        RANGE  gkbar, ik
}
 
PARAMETER {
	gkbar   =   0.002 (S/cm2)

	mvhalf = -13.5		(mV)	: Nisenbaum 1996, Fig 6C
	mslope = -11.8		(mV)	: Nisenbaum 1996, Fig 6C
	mshift = 0		(mV)

	hvhalf = -54.7		(mV)	: Nisenbaum 1996, Fig 9D
	hslope = 18.6		(mV)	: Nisenbaum 1996, Fig 9D
 	hshift = 0		(mV)

 	a = 0.7				: matched to Nisenbaum 1996, figure 9A (with qfact = 1)
 	qfact = 3.0
}
 
STATE { m h }
 
ASSIGNED {
	ek				(mV)
        v 				(mV)
        ik 				(mA/cm2)
        gk				(S/cm2)
        minf 
	hinf
    }
 
BREAKPOINT {
        SOLVE state METHOD cnexp
        gk = gkbar * m * (a*h + (1-a)) 
        ik = gk * ( v - ek )
}
 

 
INITIAL {
	rates(v)
	
	m = minf
	h = hinf
}

FUNCTION_TABLE taumkrp (v(mV))  (ms)
FUNCTION_TABLE tauhkrp (v(mV))  (ms)

DERIVATIVE state { 
        rates(v)
        m' = (minf - m) / (taumkrp(v)/qfact)
        h' = (hinf - h) / (tauhkrp(v)/qfact)
}
 
PROCEDURE rates(v (mV)) {  
	TABLE minf, hinf DEPEND mshift, hshift
		FROM -200 TO 200 WITH 201
			minf = 1 / (1 + exp( (v - mvhalf - mshift) / mslope ))
			hinf = 1 / (1 + exp( (v - hvhalf - hshift) / hslope ))
}
 
 

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