Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)

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Accession:112834
"We describe a computational model of the principal cell in the nucleus accumbens (NAcb), the medium spiny projection (MSP) neuron. The model neuron, constructed in NEURON, includes all of the known ionic currents in these cells and receives synaptic input from simulated spike trains via NMDA, AMPA, and GABAA receptors. ... results suggest that afferent information integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is altered or modulated, as has been proposed in both schizophrenia and addiction."
Reference:
1 . Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neurosci 25:9080-95 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Nucleus accumbens spiny projection neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Schizophrenia; Addiction;
Implementer(s): Wolf, John A. [johnwolf at warpmail.net]; Moyer, Jason [jtmoyer at seas.upenn.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q;
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nacb_msp
tau_tables
readme.html
AMPA.mod
bkkca.mod *
cadyn.mod *
caL.mod *
caL13.mod *
caldyn.mod
can.mod *
caq.mod *
car.mod *
cat.mod *
GABA.mod *
kaf.mod *
kas.mod *
kir.mod *
krp.mod *
naf.mod *
nap.mod *
NMDA.mod
skkca.mod *
stim.mod *
_run_me.hoc
all_tau_vecs.hoc *
baseline_values.txt *
basic_procs.hoc
create_mspcells.hoc *
current_clamp.ses *
make_netstims.hoc
mosinit.hoc *
msp_template.hoc
nacb_main.hoc
netstims_template.hoc *
screenshot.jpg
screenshot2.jpg
stimxout_jns_sqwave.dat
synapse_templates.hoc
                            
TITLE Nahc - Fast sodium current for nucleus accumbens (from hippocampal pyramidal cell)

COMMENT
Martina M, Jonas P (1997). "Functional differences in na+ channel gating between fast-
spiking interneurons and principal neurons of rat hippocampus." J Phys, 505(3): 593-603.

recorded at 22C - Q10 of 3 to convert to 35C

Jason Moyer 2004 - jtmoyer@seas.upenn.edu

ENDCOMMENT

UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
        (S)  = (siemens)
}
 
NEURON {
        SUFFIX naf
        USEION na READ ena WRITE ina
        RANGE  gnabar, ina, mshift, hshift
}
 
PARAMETER {
    gnabar   =   1.5 	(S/cm2)	: 1.5 in soma, 0.0195 in all dends

	mvhalf = -23.9		(mV)	: Martina/Jonas 1997 Table 1 (Pyr. cells)
	mslope = -11.8		(mV)	: Martina/Jonas 1997 Table 1 (Pyr. cells)
	mshift = 0		(mV)	: 

	hvhalf = -62.9		(mV)	: Martina/Jonas 1997 Table 1 (Pyr. cells)
	hslope = 10.7		(mV)	: Martina/Jonas 1997 Table 1 (Pyr. cells)
	hshift = 0		(mV)	: 

	mqfact = 3
	hqfact = 3	
}
 
STATE { m h }
 
ASSIGNED {
		ena				(mV)
        v 				(mV)
        ina 				(mA/cm2)
        gna				(S/cm2)
        minf 
	hinf
}
 
BREAKPOINT {
        SOLVE state METHOD cnexp
        gna = gnabar * m * m * m  * h
        ina = gna * ( v - ena )
}
 
 
INITIAL {
	rates(v)
	
	m = minf
	h = hinf
}

FUNCTION_TABLE taumnaf (v(mV))  (ms)	: Martina/Jonas 1997 Fig 2E
FUNCTION_TABLE tauhnaf (v(mV))  (ms)	: Martina/Jonas 1997 Fig 4C

DERIVATIVE state { 
        rates(v)
        m' = (minf - m) / (taumnaf(v)/mqfact)
        h' = (hinf - h) / (tauhnaf(v)/hqfact)
}
 
PROCEDURE rates(v (mV)) {  
	TABLE minf, hinf DEPEND mshift, hshift, mslope, hslope
		FROM -200 TO 200 WITH 201
			minf = 1 / (1 + exp( (v-mvhalf-mshift) / mslope ) ) 
		    hinf = 1 / (1 + exp( (v-hvhalf-hshift) / hslope ) )
}
 
 

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