Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)

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Accession:113997
The paper demonstrate a form of graded persistent activity activated by hyperpolarization. This phenomenon is modeled based on a slow calcium regulation of Ih, similar to that introduced earlier for thalamic neurons (see Destexhe et al., J Neurophysiol. 1996). The only difference is that the calcium signal is here provided by the high-threshold calcium current (instead of the low-threshold calcium current in thalamic neurons).
Reference:
1 . Winograd M, Destexhe A, Sanchez-Vives MV (2008) Hyperpolarization-activated graded persistent activity in the prefrontal cortex. Proc Natl Acad Sci U S A 105:7298-303 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s):
Channel(s): I Na,t; I L high threshold; I K; I M; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Ion Channel Kinetics;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I M; I h;
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HAGPA
README.html
APCounter2.mod *
Cadynamics.mod *
HH2.mod *
ICaL.mod *
Ih.mod *
IKM.mod *
ipulse3.mod *
pasi.mod *
demo_HPGA_non-saturating.hoc
demo_HPGA_non-saturating_noIh.hoc
demo_HPGA_saturating.hoc
init.hoc
mosinit.hoc *
screenshot.jpg
                            
objref nil, tobj
strdef tstr

xpanel("Figures for Winograd et al. 2008")
xradiobutton("fig 4 non-saturating", "restart(\"demo_HPGA_non-saturating.hoc\")")
xradiobutton("fig 4 non-saturating, no Ih", "restart(\"demo_HPGA_non-saturating_noIh.hoc\")")
xradiobutton("Supplemental fig 7", "restart(\"demo_HPGA_saturating.hoc\")")
xpanel(5,100)

pwmcnt = PWManager[0].count // the initial gui should not be dismissed

objref vbox, hbox[3]
use_boxes=1
proc restart() {local i
//	flush_list.remove_all()
//	fast_flush_list.remove_all()
	doNotify()
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
		PWManager[0].close(i)
		doNotify()
	}
	sprint(tstr, "%s", $s1)

	load_file(1, tstr)
	vbox.intercept(0)
	vbox.map()
}

proc new_row() {
  if ($1>0) {
    hbox[$1-1].intercept(0)
    hbox[$1-1].map()
  }

  hbox[$1]=new HBox()
  hbox[$1].intercept(1)
}

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