Effect of slowly inactivating IKdr to delayed firing of action potentials (Wu et al. 2008)

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Accession:114108
"The properties of slowly inactivating delayed-rectifier K+ current (IKdr) were investigated in NG108-15 neuronal cells differentiated with long-term exposure to dibutyryl cyclic AMP. ... The computer model, in which state-dependent inactivation of IKdr was incorporated, was also implemented to predict the firing behavior present in NG108-15 cells. ... Our theoretical work and the experimental results led us to propose a pivotal role of slowly inactivating IKdr in delayed firing of APs in NG108-15 cells. The results also suggest that aconitine modulation of IKdr gating is an important molecular mechanism through which it can contribute to neuronal firing."
Reference:
1 . Wu SN, Chen BS, Lin MW, Liu YC (2008) Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: experimental and theoretical studies. J Theor Biol 252:711-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Neuroblastoma; NG108-15 neuronal cell;
Channel(s): I Na,t; I K; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Activity Patterns; Action Potentials; Delay;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chen, Bing-Shuo;
Search NeuronDB for information about:  I Na,t; I K; I Sodium; I Potassium;
 
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