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Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
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In this simulation action potential initiation, action potential properties and the role of axon initial segment Na+ channels are investigated in a realistic model of a layer 5 pyramidal neuron axon initial segment. The main Na+ channel properties were constrained by experimental data and the axon initial segment was reconstructed. Model parameters were constrained by direct recordings at the axon initial segment.
Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment.
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Neuron or other electrically excitable cell;
Neocortex L5/6 pyramidal GLU cell;
Action Potential Initiation;
Axonal Action Potentials;
Kole, Maarten [m.kole at nin.knaw.nl];
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Neocortex L5/6 pyramidal GLU cell
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