ModelDB: Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)

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Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)

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Accession:114394

In this simulation action potential initiation, action potential properties and the role of axon initial segment Na+ channels are investigated in a realistic model of a layer 5 pyramidal neuron axon initial segment. The main Na+ channel properties were constrained by experimental data and the axon initial segment was reconstructed. Model parameters were constrained by direct recordings at the axon initial segment.
Reference:
1 . Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci 11:178-86 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Neocortex L5/6 pyramidal GLU cell;
Channel(s):	I Na,t; I K; I M; I h;
Gap Junctions:
Receptor(s):
Gene(s):	HCN1; HCN2;
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Action Potential Initiation; Active Dendrites; Axonal Action Potentials; Action Potentials;
Implementer(s):	Kole, Maarten [m.kole at nin.knaw.nl];