GPi/GPe neuron models (Johnson and McIntyre 2008)

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Accession:114685
Model files for two types of non-human primate neurons used in the paper: simplified versions of 1) a GPi neuron and 2) a GPe axon collateralizing in GPi en route to STN.
Reference:
1 . Johnson MD, McIntyre CC (2008) Quantifying the neural elements activated and inhibited by globus pallidus deep brain stimulation. J Neurophysiol 100:2549-63 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism:
Cell Type(s): Globus pallidus neuron;
Channel(s): I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Axonal Action Potentials; Parkinson's; Extracellular Fields;
Implementer(s): Johnson, Matthew D [johnsom11 at ccf.org];
Search NeuronDB for information about:  I Sodium; I Calcium; I Potassium;
load_file("GPi_hocProps.ses")

xpanel("Johnson and McIntyre 2008")
  xlabel("Choose a simulation by pressing a below button")
  xbutton("Short test run of the GPi neuron similar to Fig 1A", "short_run()")
  xlabel("The above shows an AP similar to those in Fig 1A (right).")
  xbutton("Sample run for the current injections that created Fig 2C","fig2c_point()")
  xlabel("The above sample simulation is set to ")
  xlabel("i_inj=.5 nA and g_NaL = 28 uS")
  xlabel("Additional files for simulating the response of these cells")
  xlabel("to deep brain stimulation can be requested by contacting the")
  xlabel("authors: johnsom11@ccf.org")
xpanel()

proc short_run() {
  save_tstop=tstop
  tstop = 10
  init()
  run()
  tstop=save_tstop
  Graph[0].exec_menu("View = plot")
}

proc fig2c_point() {

  finitialize(v_init)
  fcurrent()

  init()
  run()
}

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