GPi/GPe neuron models (Johnson and McIntyre 2008)

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Accession:114685
Model files for two types of non-human primate neurons used in the paper: simplified versions of 1) a GPi neuron and 2) a GPe axon collateralizing in GPi en route to STN.
Reference:
1 . Johnson MD, McIntyre CC (2008) Quantifying the neural elements activated and inhibited by globus pallidus deep brain stimulation. J Neurophysiol 100:2549-63 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism:
Cell Type(s): Globus pallidus neuron;
Channel(s): I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Axonal Action Potentials; Parkinson's; Extracellular Fields;
Implementer(s): Johnson, Matthew D [johnsom11 at ccf.org];
Search NeuronDB for information about:  I Sodium; I Calcium; I Potassium;
TITLE calcium accumulation for GPi neuron model

COMMENT 

    From: Gillies and Willshaw (2006) and as implemented by Miocinovic (2006)

    Calcium accumulation into a volume of area*depth next to the
    membrane with an exponential decay (time constant tau) to resting
    level (given by the global calcium variable cai0_ca_ion).

ENDCOMMENT

NEURON {
    SUFFIX cacum
    USEION ca READ ica WRITE cai
    GLOBAL depth, tau, cai0
}

UNITS {
    (mM) = (milli/liter)
    (mA) = (milliamp)
    F = (faraday) (coulombs)	: Faraday constant 
}

PARAMETER {
    depth = 200 (nm)      : assume volume = area * depth
    tau = 10 (ms)
    cai0 = 5e-5 (mM)
    cai0_ca_ion
}

ASSIGNED {
    ica (mA/cm2)
}

STATE {
    cai (mM)
}

INITIAL {
    cai=cai0
}

BREAKPOINT {
    SOLVE integrate METHOD derivimplicit
}

DERIVATIVE integrate {
    cai' = -ica/depth/F/2 * (1e7) + (cai0 - cai)/tau
}

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