We show that the Na+ channel NaV1.6 displays a striking aggregation at the AIS
of cortical neurons.
In combination with simulations using a realistic
computer model of a CA1 pyramidal cell, our results imply that a hyperpolarized
voltage-dependence of activation of AIS NaV1.6 channels is important both in
determining spike threshold and localizing spike initiation to the AIS.
These results suggest that NaV1.6 subunits at the AIS contribute significantly to
its role as spike trigger zone and shape repetitive discharge properties of CA1 neurons."
Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. J Neurophysiol 100:2361-80 [PubMed]