Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008)

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Accession:115356
"... We show that the Na+ channel NaV1.6 displays a striking aggregation at the AIS of cortical neurons. ... In combination with simulations using a realistic computer model of a CA1 pyramidal cell, our results imply that a hyperpolarized voltage-dependence of activation of AIS NaV1.6 channels is important both in determining spike threshold and localizing spike initiation to the AIS. ... These results suggest that NaV1.6 subunits at the AIS contribute significantly to its role as spike trigger zone and shape repetitive discharge properties of CA1 neurons."
Reference:
1 . Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. J Neurophysiol 100:2361-80 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I p,q; I A; I K; I M; I h; I K,Ca; I Calcium; I Q;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.6 SCN8A;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Temporal Pattern Generation;
Implementer(s): Horstmann, Marie-Therese [mhorstma at uni-bonn.de];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I p,q; I A; I K; I M; I h; I K,Ca; I Calcium; I Q;
: K-Strom, I_CT,  Stacey, Durand 2000
: eK from Martina

UNITS 
{
        (molar) = (1/liter)
	(mM) = (millimolar)
        (mA) = (milliamp)
        (mV) = (millivolt)
	(S) = (siemens)
}
 
NEURON {
        SUFFIX KCT
	USEION ca READ cai
	USEION k WRITE ik
        RANGE gCTbar, gCT
        GLOBAL cinf, dinf, dtau, ctau
}
 
PARAMETER 
{
        gCTbar = 0.120 (S/cm2)	<0,1e9>
        eK = -95 (mV)
	ctau = 0.55 (ms)
}
 

STATE 
{
        c d
}
 
ASSIGNED 
{
        ik (mA/cm2)
        cai (mM)
        v (mV)
        celsius (degC)
	gCT (S/cm2)
	cinf
	dinf
	dtau (ms)
:	ctau (ms)
}
 

BREAKPOINT 
{
        SOLVE states METHOD cnexp
        gCT = gCTbar*c*c*d
	ik = gCT*(v - eK)
}
 
 
INITIAL 
{
	rates(v)
	c = cinf
	d = dinf
}

DERIVATIVE states 
{  
        rates(v)
 
        c' =  (cinf-c)/ctau
	d' = (dinf-d)/dtau
}
 
LOCAL q10


PROCEDURE rates(v(mV))   :Computes rate and other constants at current v.
                      :Call once from HOC to initialize inf at resting v.
{
        LOCAL  alpha, beta, sum, vshift

UNITSOFF
               
        vshift = 40 * log10(cai)
        q10 = 3^((celsius - 6.3)/10)
                :"c" potassium activation system

        alpha = -0.0077 * vtrap(v+vshift+103, -12)
        beta =  1.7 / exp((v+vshift+237)/30)
        sum = alpha + beta
	: see Warman
	:	ctau = 1/sum
        cinf = alpha/sum
	: "d" activation
	alpha = 1/(exp((v+79)/10))
	beta = 4/(exp((v-82)/-27)+1)
	sum = alpha + beta
	dinf = alpha/sum
	dtau = 1/sum 
}
 
FUNCTION vtrap(x,y) {  :Traps for 0 in denominator of rate eqns.
        if (fabs(x/y) < 1e-6) {
                vtrap = y*(1 - x/y/2)
        }else{
                vtrap = x/(exp(x/y) - 1)
        }
}
 
 
UNITSON

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