A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)

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Accession:116575
The leech C-interneuron and its electrical synapse with the S-interneuron exhibit unusual properties: an asymmetric delay when impulses travel from one soma to the other, and graded C-interneuron impulse amplitudes under elevated divalent cation concentrations. These properties have been simulated using a SNNAP model in which the C-interneuron has multiple, independent spike initiation zones associated with individual electrical junctions with the C-interneuron.
Reference:
1 . Crisp KM (2009) Multiple spike initiation zones in a neuron implicated in learning in the leech: a computational model. Invert Neurosci 9:1-10 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Leech C interneuron;
Channel(s): I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: SNNAP;
Model Concept(s): Action Potential Initiation; Action Potentials;
Implementer(s): Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium; Glutamate;
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Crisp2009
readme.html
1.8mM_ADP.vdg *
1.8mM_Ca.vdg *
1.8mM_divalents.sm *
1.8mM_Na.vdg *
25mM_ADP.vdg
25mM_Ca.vdg
25mM_divalents.sm
25mM_Na.vdg
ADP.m *
ADP.vdg *
alpha.fAt
AxonalRes.es
C.neu
C1234.neu
C1a.neu
C1a_leak.R *
C1a_leak.vdg
C1b_leak.R *
C1b_leak.vdg
C1c_leak.R *
C1c_leak.vdg
C1d.neu
C1d_leak.R *
C1d_leak.vdg
C2a.neu
C3a.neu
C4a.neu
C4a_leak.R *
C4a_leak.vdg
C4b.neu
C4b_leak.R *
C4b_leak.vdg
C4c.neu
C4c_leak.R *
C4c_leak.vdg
C4d.neu
C4d_leak.R *
C4d_leak.vdg
Ca.fBR *
Ca.ion *
Ca.ion.tmp *
Ca.m *
Ca.vdg *
CCellModel.ntw
divalents.fBR
divalents.sm *
divalents.tr
divalentsCa.fBR
fAHP.m *
fAHP.vdg *
Figure2.smu
Figure2.smu.exec
Figure2.smu.hmn
Figure2.smu.ing
Figure2.smu.out.head
glutamate.cs
Kdr.m *
Kdr.vdg *
leak.R *
leak.vdg
leak_pas.vdg *
leakC1a.R *
mAHP.A *
mAHP.vdg *
Na.h *
Na.m *
Na.vdg *
netwf
netwfile
new.R
new.r.tmp
new2.R
new2.R.tmp
ousgrf.def *
pleak.vdg *
R.neu
r.r
R1.neu
S.neu
S_ExcitableNeurite_1.8mM.neu
S123.neu
Sabcd.neu
SC.es
screenshot.jpg
simufiles.usd
SNNAP_CCell.bas
Stim_S_Rec_C.ous
Stim_S_Rec_C.ous.mnu
Stim_S_Rec_C.trt
Stim_S_Stim_C.ous
Stim_S_Stim_C.ous.mnu
Stim_S_Stim_C.trt
vbas31w.sll
vgui31w.sll
voflr31w.sll
                            
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>    modules name< ION		>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>


		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Cion:		> 	Concentration of an ion				>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

>----------------------->------------------------------------------------------>
>	1		>						       >
>	0.	>Vc< 	>				-------		       >
>	0.	>K1<	>				       \	       >
>	0.	>K2<	>				        \	       >
>	0.	>K3<	>	dCion     CIion - Iu - Id	|	       >
>	0.	>Dgain<	>	----- = -----------------	|	       >
>	0.	>Dmid<	>	 dt             Vc		|	       >
>	0.	>p<	>					|	       >
>			>		     +--       -+	|	       >
>			>		     | -------  |	|	       >
>			>		     | \        |	|	       >
>			>	CIion = K1 x |- > Iion  | - K2	|	       >
>			>		     | /        |	 >	(1)    >
>			>		     | -------  |	|	       >
>			>		     +--       -+	|	       >
>			>					|	       >
>			>		Dgain			|	       >
>			>	Iu = ---------------		|	       >
>			>			    p		|	       >
>			>		1+ dmid/Cion		|	       >
>			>					|	       >
>			>	Id = K3 x Cion			|	       >
>			>					/	       >
>			>				       /	       >
>			>				-------		       >
>			>						       >
>----------------------->------------------------------------------------------>
	2		>		    |     +-	    -+       |	       >
	5.0		>K1<	>		    |     | -------  |	     |	       >
	1.0		>K2<	>	dCion	    |     | \        |	     |	       >
			>	-----= K1 x |K2 x |- > Iion  | -Cion |	(2)    >
			>		    |     | -------  |	     |	       >
			>		    |     +-	    -+       |	       >

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