A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)

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Accession:116575
The leech C-interneuron and its electrical synapse with the S-interneuron exhibit unusual properties: an asymmetric delay when impulses travel from one soma to the other, and graded C-interneuron impulse amplitudes under elevated divalent cation concentrations. These properties have been simulated using a SNNAP model in which the C-interneuron has multiple, independent spike initiation zones associated with individual electrical junctions with the C-interneuron.
Reference:
1 . Crisp KM (2009) Multiple spike initiation zones in a neuron implicated in learning in the leech: a computational model. Invert Neurosci 9:1-10 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Leech C interneuron;
Channel(s): I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: SNNAP;
Model Concept(s): Action Potential Initiation; Action Potentials;
Implementer(s): Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium; Glutamate;
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Crisp2009
readme.html
1.8mM_ADP.vdg *
1.8mM_Ca.vdg *
1.8mM_divalents.sm *
1.8mM_Na.vdg *
25mM_ADP.vdg
25mM_Ca.vdg
25mM_divalents.sm
25mM_Na.vdg
ADP.m *
ADP.vdg *
alpha.fAt
AxonalRes.es
C.neu
C1234.neu
C1a.neu
C1a_leak.R *
C1a_leak.vdg
C1b_leak.R *
C1b_leak.vdg
C1c_leak.R *
C1c_leak.vdg
C1d.neu
C1d_leak.R *
C1d_leak.vdg
C2a.neu
C3a.neu
C4a.neu
C4a_leak.R *
C4a_leak.vdg
C4b.neu
C4b_leak.R *
C4b_leak.vdg
C4c.neu
C4c_leak.R *
C4c_leak.vdg
C4d.neu
C4d_leak.R *
C4d_leak.vdg
Ca.fBR *
Ca.ion *
Ca.ion.tmp *
Ca.m *
Ca.vdg *
CCellModel.ntw
divalents.fBR
divalents.sm *
divalents.tr
divalentsCa.fBR
fAHP.m *
fAHP.vdg *
Figure2.smu
Figure2.smu.exec
Figure2.smu.hmn
Figure2.smu.ing
Figure2.smu.out.head
glutamate.cs
Kdr.m *
Kdr.vdg *
leak.R *
leak.vdg
leak_pas.vdg *
leakC1a.R *
mAHP.A *
mAHP.vdg *
Na.h *
Na.m *
Na.vdg *
netwf
netwfile
new.R
new.r.tmp
new2.R
new2.R.tmp
ousgrf.def *
pleak.vdg *
R.neu
r.r
R1.neu
S.neu
S_ExcitableNeurite_1.8mM.neu
S123.neu
Sabcd.neu
SC.es
screenshot.jpg
simufiles.usd
SNNAP_CCell.bas
Stim_S_Rec_C.ous
Stim_S_Rec_C.ous.mnu
Stim_S_Rec_C.trt
Stim_S_Stim_C.ous
Stim_S_Stim_C.ous.mnu
Stim_S_Stim_C.trt
vbas31w.sll
vgui31w.sll
voflr31w.sll
                            
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>    modules name< fAt		>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>


fAt:		>> Function of time-dependent activation >>

>----------------------->----------------------------------------------->
	1		>	fAt = At			(1)	>
			>						>
>----------------------->----------------------------------------------->
>	2		>	fAt =  At/Apeak			(2)	>
>			>						>
>----------------------->----------------------------------------------->
>	3		>	fAt = a + b x At		(3)	>
>	xxx.xx	>a< 	>						>
>	xxx.xx	>b< 	>						>
>			>						>
>----------------------->----------------------------------------------->
>	4		>			1			>
>	xxx.xx	>b< 	>	fAt = --------------------	(4)	>
>			>		1 +  b x At			>
>			>						>
>----------------------->----------------------------------------------->
>	5		>	fAt = a + b x u x At		(5)	>
>	xxx.xx	>a< 	>						>
>	xxx.xx	>b< 	>						>
>			>						>
>----------------------->----------------------------------------------->
>	6		>			1			>
>	xxx.xx	>a< 	>	fAt = --------------------	(6)	>
>			>		1 +  a x u x At			>
>			>						>
>----------------------->----------------------------------------------->


		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
At:		> 	Time dependent Activation			>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
>----------------------->------------------------------------------------------>
	1		>		-t/u				       >
	0.0020		>u< 	>	At = t e				(1)    >
			>						       >
>----------------------->------------------------------------------------------>
>	2		>	      u1 x u2    -t/u1    -t/u2		       >
>	xxx.xx	>u1< 	>	At = --------- [e      - e      ]	(2)    >
>	xxx.xx	>u2< 	>	      u1 - u2				       >
>			>						       >
>----------------------->------------------------------------------------------>
>	3		>	 2					       >
>	filename  >Xt<	>       File Name  				       >
>	xxx.xx	>u< 	>	d At     Xt - 2 x u x (dAt/dt) - At	       >
>			>	----- = ---------------------------- 	(3)    >
>			>	 dt                  2			       >
>			>	                   u  			       >
>			>						       >
>----------------------->------------------------------------------------------>
>	4		>	 2					       >
>	filename  >Xt<	>       File Name  				       >
>	xxx.xx	>u1< 	>	d At     Xt - (u1 + u2) x (dAt/dt) - At	       >
>	xxx.xx	>u2< 	>	----- = -------------------------------	(4)    >
>			>	 dt                u1 x u2		       >
>			>						       >
>----------------------->------------------------------------------------------>
>	5		>						       >
>	filename  >Xt<	>       File Name  				       >
>		 	>	At = Xt					(5)    >
>			>						       >
>----------------------->------------------------------------------------------>
END;

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