A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)

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Accession:116575
The leech C-interneuron and its electrical synapse with the S-interneuron exhibit unusual properties: an asymmetric delay when impulses travel from one soma to the other, and graded C-interneuron impulse amplitudes under elevated divalent cation concentrations. These properties have been simulated using a SNNAP model in which the C-interneuron has multiple, independent spike initiation zones associated with individual electrical junctions with the C-interneuron.
Reference:
1 . Crisp KM (2009) Multiple spike initiation zones in a neuron implicated in learning in the leech: a computational model. Invert Neurosci 9:1-10 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Leech C interneuron;
Channel(s): I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: SNNAP;
Model Concept(s): Action Potential Initiation; Action Potentials;
Implementer(s): Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium; Glutamate;
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Crisp2009
readme.html
1.8mM_ADP.vdg *
1.8mM_Ca.vdg *
1.8mM_divalents.sm *
1.8mM_Na.vdg *
25mM_ADP.vdg
25mM_Ca.vdg
25mM_divalents.sm
25mM_Na.vdg
ADP.m *
ADP.vdg *
alpha.fAt
AxonalRes.es
C.neu
C1234.neu
C1a.neu
C1a_leak.R *
C1a_leak.vdg
C1b_leak.R *
C1b_leak.vdg
C1c_leak.R *
C1c_leak.vdg
C1d.neu
C1d_leak.R *
C1d_leak.vdg
C2a.neu
C3a.neu
C4a.neu
C4a_leak.R *
C4a_leak.vdg
C4b.neu
C4b_leak.R *
C4b_leak.vdg
C4c.neu
C4c_leak.R *
C4c_leak.vdg
C4d.neu
C4d_leak.R *
C4d_leak.vdg
Ca.fBR *
Ca.ion *
Ca.ion.tmp *
Ca.m *
Ca.vdg *
CCellModel.ntw
divalents.fBR
divalents.sm *
divalents.tr
divalentsCa.fBR
fAHP.m *
fAHP.vdg *
Figure2.smu
Figure2.smu.exec
Figure2.smu.hmn
Figure2.smu.ing
Figure2.smu.out.head
glutamate.cs
Kdr.m *
Kdr.vdg *
leak.R *
leak.vdg
leak_pas.vdg *
leakC1a.R *
mAHP.A *
mAHP.vdg *
Na.h *
Na.m *
Na.vdg *
netwf
netwfile
new.R
new.r.tmp
new2.R
new2.R.tmp
ousgrf.def *
pleak.vdg *
R.neu
r.r
R1.neu
S.neu
S_ExcitableNeurite_1.8mM.neu
S123.neu
Sabcd.neu
SC.es
screenshot.jpg
simufiles.usd
SNNAP_CCell.bas
Stim_S_Rec_C.ous
Stim_S_Rec_C.ous.mnu
Stim_S_Rec_C.trt
Stim_S_Stim_C.ous
Stim_S_Stim_C.ous.mnu
Stim_S_Stim_C.trt
vbas31w.sll
vgui31w.sll
voflr31w.sll
                            
NEURONS
C C.neu white
C1 C1234.neu white
C1a C1a.neu white
C2 C1234.neu white
C2a C2a.neu white
C3 C1234.neu white
C3a C3a.neu white
C4 C1234.neu white
C4a C4a.neu white
R R.neu blue
R1 R1.neu blue
S S.neu red
S1 S123.neu red
S1a Sabcd.neu red
S2 S123.neu red
S2a Sabcd.neu red
S3 S123.neu red
S3a Sabcd.neu red
S4 S123.neu red
S4a Sabcd.neu red
CONNECTIONS
C1 R1 c1 glutamate 0 glutamate.cs N green
C1 C e 0 0 AxonalRes.es N white
C1 C2 e 0 0 AxonalRes.es N white
C1a C1 e 0 0 AxonalRes.es N white
C1a S1a e 0 0 SC.es N white
C2 C2a e 0 0 AxonalRes.es N white
C2 C3 e 0 0 AxonalRes.es N white
C2 C4 e 0 0 AxonalRes.es N white
C2a S3a e 0 0 SC.es N white
C3 C3a e 0 0 AxonalRes.es N white
C3a S2a e 0 0 SC.es N white
C4 C4a e 0 0 AxonalRes.es N white
C4a S4a e 0 0 SC.es N white
R R1 e 0 0 AxonalRes.es N blue
S S1 e 0 0 AxonalRes.es N red
S1 S1a e 0 0 AxonalRes.es N white
S2 S2a e 0 0 AxonalRes.es N white
S3 S2 e 0 0 AxonalRes.es N white
S3 S3a e 0 0 AxonalRes.es N white
S3 S4 e 0 0 AxonalRes.es N white
S4 S4a e 0 0 AxonalRes.es N white
S1 S2 e 0 0 AxonalRes.es N white
S1 S3 e 0 0 AxonalRes.es N white

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