Sodium potassium ATPase pump (Chapman et al. 1983)

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Accession:120692
The electrochemical properties of a widely accepted six-step reaction scheme for the Na,K-ATPase have been studied by computer simulation.
Reference:
1 . Chapman JB, Johnson EA, Kootsey JM (1983) Electrical and biochemical properties of an enzyme model of the sodium pump. J Membr Biol 74:139-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s): Hodgkin-Huxley neuron;
Channel(s): Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Sodium pump;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Na/K pump;
{load_file("fig11-12.ses")}

double c[8]

proc fig11() {
	std()
	pv(Graph[0], &kbind)
	pv(Graph[0], &nabind)
}
proc comp() {local rt, fv, i
	rt = R*T_nakpump
	fv = FARADAY*$1
	init($1)
	kbind = (k2e_nakpump + k2eatp_nakpump)/totalpump_nakpump
	nabind = (na3eatp_nakpump + na3ep_nakpump)/totalpump_nakpump
	c[0] = 3*rt*log(naout_nakpump/nain_nakpump) + 2*rt*log(kin_nakpump/kout_nakpump)
	c[0] *= 1e-3
	c[1] = c[0] - fv*1e-6
	for i=1,5 {
		c[i+1] = c[i] + rt*log(rf_nakpump[i]/rb_nakpump[i])*1e-3
	}
}
proc pv() {
	$o1.beginline(1,1)
	for (v_init = -250; v_init <= 50; v_init += 1) {
		comp(v_init)
		$o1.line(v_init, $&2)
	}
	$o1.flush()
	v_init = 0
}
	
fig11()

proc fig12() {local i, d
	std()
	for i=0, 7 {
		pv(Graph[1], &c[i])
	}
	d = atp_nakpump - 3.0
	atp_nakpump -= d
	adp_nakpump += d
	
	for i=0, 7 {
		pv(Graph[2], &c[i])
	}
	std()
}
fig12()

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