Sodium potassium ATPase pump (Chapman et al. 1983)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:120692
The electrochemical properties of a widely accepted six-step reaction scheme for the Na,K-ATPase have been studied by computer simulation.
Reference:
1 . Chapman JB, Johnson EA, Kootsey JM (1983) Electrical and biochemical properties of an enzyme model of the sodium pump. J Membr Biol 74:139-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s): Hodgkin-Huxley neuron;
Channel(s): Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Sodium pump;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Na/K pump;
{load_file(1, "fig4-6.ses")}

proc fig45() {localobj g, g5
	std()
	g = Graph[0]
	g5 = Graph[1]
	pv(g,1) pc(g5)
	// discrepancy in following rates, line B in Fig 4
	b2_nakpump=1e7
	f3_nakpump=1000 b3_nakpump=5e4
	f4_nakpump=1e8 b4_nakpump=1.33e6
	b5_nakpump=1 f6_nakpump=1.91e4
	pv(g,1) pc(g5)
	std()
	f5_nakpump=2e5
	f6_nakpump=115 b6_nakpump=6e5
	pv(g,1) pc(g5)
}
proc pv() {
	$o1.beginline($2,1)
	for (v_init = -250; v_init <= 50; v_init += 1) {
		init()
		$o1.line(v_init, atpact_nakpump)
	}
	$o1.flush()
}
proc pc() {
	$o1.beginline()
	for (na=0; na <= 150; na += 1) {
		nain_nakpump = naout_nakpump = na
		kin_nakpump = kout_nakpump = 150 - na
		init()
		$o1.line(na, atpact_nakpump)
	}
	$o1.flush()
}
fig45()

proc fig6() {localobj g
	g = Graph[2]
	std()
	pv(g,1)
	atp_nakpump -= 1.99  adp_nakpump += 1.99
	pv(g,1)
	std()
	naout_nakpump = 200  kout_nakpump = 0.1
	pv(g,1)
}
fig6()


Loading data, please wait...