ModelDB: Balance of excitation and inhibition (Carvalho and Buonomano 2009)

Balance of excitation and inhibition (Carvalho and Buonomano 2009)

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Accession:125689

" ... Here, theoretical analyses reveal that excitatory synaptic strength controls the threshold of the neuronal input-output function, while inhibitory plasticity alters the threshold and gain. Experimentally, changes in the balance of excitation and inhibition in CA1 pyramidal neurons also altered their input-output function as predicted by the model. These results support the existence of two functional modes of plasticity that can be used to optimize information processing: threshold and gain plasticity."
Reference:
1 . Carvalho TP, Buonomano DV (2009) Differential effects of excitatory and inhibitory plasticity on synaptically driven neuronal input-output functions. Neuron 61:774-85 [PubMed]

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Model Type:	Neuron or other electrically excitable cell;
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Simulation Environment:	NEURON; MATLAB;
Model Concept(s):	Synaptic Integration;
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