Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)

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Accession:127507
A dopaminergic (DA) neuron model with a morphologicaly realistic dendritic architecture. The model captures several salient features of DA neurons under different pharmacological manipulations and exhibits depolarization block for sufficiently high current pulses applied to the soma.
Reference:
1 . Kuznetsova AY, Huertas MA, Kuznetsov AS, Paladini CA, Canavier CC (2010) Regulation of firing frequency in a computational model of a midbrain dopaminergic neuron. J Comput Neurosci 28:389-403 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Substantia nigra pars compacta DA cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I K,Ca; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Temporal Pattern Generation; Oscillations;
Implementer(s): Huertas, Marco [huertas.marco at gmail.com];
Search NeuronDB for information about:  Substantia nigra pars compacta DA cell; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I K,Ca; Na/K pump;
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KuznetsovaEtAl2010
README.html
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nabalan.mod *
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dopaminergic.hoc
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Fig6a_dashed-line_trace.hoc
Fig6a_solid_trace.hoc
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mosinit.hoc
run_and_graph.ses
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TITLE applied current

COMMENT
Since this is an electrode current, positive values of i depolarize
the cell and in the presence of the extracellular mechanism there will be a
change in vext since i is not a transmembrane current but a current injected
directly to the inside of the cell.
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	POINT_PROCESS MyIClamp
	RANGE del,dur,amp,amp2,i
	ELECTRODE_CURRENT i
}
UNITS {
	(nA) = (nanoamp)
}

PARAMETER {
	del  (ms)
	dur  (ms)	<0,1e9>
	amp  (nA)
	amp2 (nA)
}
ASSIGNED { i (nA) }

INITIAL {
	i = amp
}

BREAKPOINT {
	at_time(del)
	at_time(del+dur)

	if (t < del + dur && t > del) {
		i = amp +amp2
	}else{
		i = amp
	}
}

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