Functional structure of mitral cell dendritic tuft (Djurisic et al. 2008)

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Accession:136026
The computational modeling component of Djurisic et al. 2008 addressed two primary questions: whether amplification by active currents is necessary to explain the relatively mild attenuation suffered by tuft EPSPs spreading along the primary dendrite to the soma; what accounts for the relatively uniform peak EPSP amplitude throughout the tuft. These simulations show that passive spread from tuft to soma is sufficient to yield the low attenuation of tuft EPSPs, and that random distribution of a biologically plausible number of excitatory synapses throughout the tuft can produce the experimentally observed uniformity of depolarization.
Reference:
1 . Djurisic M, Popovic M, Carnevale N, Zecevic D (2008) Functional structure of the mitral cell dendritic tuft in the rat olfactory bulb. J Neurosci 28:4057-68 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell;
Channel(s): I K; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Synaptic Integration; Olfaction;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I K; I Sodium;
// $Id: init_spiketuft.hoc,v 1.5 2007/03/17 01:39:29 ted Exp $

POPOVIC = 1  // use cell params from Popovic et al., 2005

/*
Based on init_probetuft.hoc

Attaches an SEClamp to the tuft origin to drive the tuft with an
experimentally recorded spike waveform--specifically, the 
primary dendrite recording made under "soma strong" stimulation
as described in 
Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L. (1999) 
Computational Analysis of Action Potential Initiation in Mitral Cell Soma and 
Dendrites Based on Dual Patch Recordings. Journal of Neurophysiology 82:3006.
and available from ModelDB (accession number 3342, URL
http://senselab.med.yale.edu/senselab/modeldb/ShowModel.asp?model=3342 ).

vpri_somastrong.dat

Displays peak amplitude of the spike throughout the tuft.
*/

load_file("nrngui.hoc")
load_file("colors.hoc")

if (POPOVIC) {
  load_file("cell_popovic.ses")
} else {
  load_file("cell_70_3_9p5_rest0.ses")
}

load_file("fixgrid_spiketuft.hoc")  // turn off Continuous Create
  // then double Ra and cm, regrid the model using d_lambda rule, and finally restore Ra and cm

load_file("rig_spiketuft.ses")  // RunControl and v graph
load_file("instrument_spiketuft.hoc")  // inserts monx and computes distances over tuft subset
load_file("spikeclamp_spiketuft.hoc")  // puts an SEClamp at origin of tuft
  // that will be used to drive this point with a recorded spike waveform
load_file("analyze_spiketuft.hoc")  // analyze results
load_file("plots_spiketuft.hoc")  // display results
load_file("control_spiketuft.hoc")  // execute simulation, control analysis, display, and storage of results

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