CA1 stratum radiatum interneuron multicompartmental model (Katona et al. 2011)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:136176
The model examines dendritic NMDA-spike generation and propagation in the dendrites of CA1 stratum radiatum interneurons. It contains NMDA-channels in a clustered pattern on a dendrite and K-channels. The simulation shows the whole NMDA spike and the rising phase of the traces in separate windows.
Reference:
1 . Katona G, Kaszás A, Turi GF, Hájos N, Tamás G, Vizi ES, Rózsa B (2011) Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons. Proc Natl Acad Sci U S A 108:2148-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 stratum radiatum interneuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models;
Implementer(s): Rozsa, Balazs ;
Search NeuronDB for information about:  NMDA; I Na,t; I K;
load_file("T0810142_3aATIS.hoc")//the cell

forall {
	nseg=9
	insert pas
	e_pas=-60

	g_pas=0.00005

	cm=2
}

forsec basal {nseg=9 diam=diam*0.9}

dend[16].nseg=17
dend[40].nseg=200


//load_file("11_12.ses")//the cell
load_file("basal.ses")

forall{
	insert hh3
	gnabar_hh3=0.0
	gkbar_hh3=0.003

	l_hh3=0
}

ena=70
taus_hh3=30
tausv_hh3=10
tausn_hh3=5
tausb_hh3=0.1
taun_hh3=.5
forsec somatic {
	nseg=9
	gnabar_hh3=0
	gkbar_hh3=0.01
}


Loading data, please wait...