CA1 stratum radiatum interneuron multicompartmental model (Katona et al. 2011)

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Accession:136176
The model examines dendritic NMDA-spike generation and propagation in the dendrites of CA1 stratum radiatum interneurons. It contains NMDA-channels in a clustered pattern on a dendrite and K-channels. The simulation shows the whole NMDA spike and the rising phase of the traces in separate windows.
Reference:
1 . Katona G, Kaszás A, Turi GF, Hájos N, Tamás G, Vizi ES, Rózsa B (2011) Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons. Proc Natl Acad Sci U S A 108:2148-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 stratum radiatum interneuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models;
Implementer(s): Rozsa, Balazs ;
Search NeuronDB for information about:  NMDA; I Na,t; I K;
objectvar save_window_, rvp_
objectvar scene_vector_[8]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(16,62,1)}

//Begin PointProcessGroupManager
{
load_file("pointgrp.hoc")
}
{
ocbox_ = new PointProcessGroupManager(0)
}
{object_push(ocbox_)}
{
ms = new MechanismStandard("IClamp")
ms.set("del", 20, 0)
ms.set("dur", 5, 0)
ms.set("amp", 0, 0)
mnews("IClamp", ms)
select(0)
execute("soma ocbox_.move(0.5)")
ms = new MechanismStandard("dsyn")
ms.set("gmax", 1.8, 0)
ms.set("tau1", 23, 0)
ms.set("tau2", 2, 0)
ms.set("del", 20, 0)
ms.set("Tspike", 10, 0)
ms.set("Nspike", 1, 0)
mnews("dsyn", ms)
select(1)
execute("dend[56] ocbox_.move(0.0882353)")
ms = new MechanismStandard("nmda_m")
ms.set("gmax", 14, 0)
ms.set("e", 0, 0)
ms.set("gw", 14, 0)
ms.set("del", 30, 0)
ms.set("Tspike", 10, 0)
ms.set("Nspike", 1, 0)
mnews("nmda_m", ms)
select(2)
execute("apic[24] ocbox_.move(0.7)")
ms = new MechanismStandard("nmda_m")
ms.set("gmax", 14, 0)
ms.set("e", 0, 0)
ms.set("gw", 14, 0)
ms.set("del", 30, 0)
ms.set("Tspike", 10, 0)
ms.set("Nspike", 1, 0)
mnews("nmda_m", ms)
select(3)
execute("apic[24] ocbox_.move(0.2)")
ms = new MechanismStandard("nmda_m")
ms.set("gmax", 14, 0)
ms.set("e", 0, 0)
ms.set("gw", 14, 0)
ms.set("del", 30, 0)
ms.set("Tspike", 10, 0)
ms.set("Nspike", 1, 0)
mnews("nmda_m", ms)
select(4)
execute("apic[24] ocbox_.move(0.1)")
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessGroupManager", 405, 74, 1180.8, 567.9)
}
objref ocbox_
//End PointProcessGroupManager


//Begin LinearCircuit[0]
{
load_file("lincir.hoc", "LinearCircuit")
}
{
ocbox_ = new LinearCircuit(1)
}
{object_push(ocbox_)}
{version(2)}
{mkelm(8, 150, 40, 2, 0)}
{mklabel(0, "soma(0.5)", 15.833, -11.7611)}
{sel.extra_info.set("soma", 0.5) sel.extra_info.name(sel)}
{mkelm(1, 130, 120, 2, 0)}
15
{mklabel(0, "Re", 1.328, 18.629)}
{mkelm(0, 150, 90, 3, -1.5708)}
{mkelm(2, 110, 95, 2.5, -1.5708)}
0.0005
{mklabel(0, "Ce", -10.1548, -17.5376)}
{mkelm(6, 110, 50, 2, 0)}
{mkelm(6, 70, 50, 2, 0)}
{mkelm(5, 70, 95, 2.5, 1.5708)}
{mklabel(0, "ie", 15, 15)}
{sel.extra_info.restore()}
3
20 0
200 0
10 0
{mkelm(0, 90, 120, 2, 0)}
{mkelm(8, 310, 40, 2, 0)}
{mklabel(0, "dend[56](0.0882353)", -3.574, -18.7429)}
{sel.extra_info.set("dend[56]", 0.0882353) sel.extra_info.name(sel)}
{mkelm(0, 310, 85, 2.5, -1.5708)}
{mkelm(1, 290, 110, 2, 0)}
100
{mklabel(0, "rdend", -1.701, 16.01)}
{mkelm(0, 250, 110, 2, 0)}
{mkelm(5, 230, 90, 2, 1.5708)}
{mklabel(0, "idend", -13.925, 21.029)}
{sel.extra_info.restore()}
3
10 0
10 0
10 0
{mkelm(6, 230, 50, 2, 0)}
{mkelm(6, 270, 50, 2, 0)}
{mkelm(2, 270, 90, 2, 1.5708)}
0.0005
{mklabel(0, "cdend", -17.813, -17.6065)}
{parasitic_ = 0  noconsist_ = 0}
{graphlist.append(new LincirGraph(this, 1))}
4
1 (mV)
2 3 0.8 0.9 2
2 (mV)
1 3 0.8 0.9 2
3 (mV)
5 1 0.8 0.9 2
4 (mV)
9 1 0.8 0.9 2
0 100 -67 19 // graph size
1123 -17 331.2 482.4 // box size
// end info
{graphlist.append(new LincirGraph(this, 1))}
2
4 (mV)
1 1 0.8 0.9 2
3 (mV)
2 1 0.8 0.9 2
0 100 -70 50 // graph size
498 60 325.8 432 // box size
// end info
{g.exec_menu("Simulate")  tool(2)}
{sel = nil}
{object_pop()}
{
{
save_window_=ocbox_.g
save_window_.size(0,300,0,200)
scene_vector_[3] = save_window_
ocbox_.g = save_window_
save_window_.save_name("ocbox_.g")
save_window_.label(165.833, 28.2389, "soma(0.5)", 1, 1, 0.5, 0.5, 1)
save_window_.label(131.328, 138.629, "Re", 1, 1, 0.5, 0.5, 1)
save_window_.label(99.8452, 77.4624, "Ce", 1, 1, 0.5, 0.5, 1)
save_window_.label(85, 110, "ie", 1, 1, 0.5, 0.5, 1)
save_window_.label(306.426, 21.2571, "dend[56](0.0882353)", 1, 1, 0.5, 0.5, 1)
save_window_.label(288.299, 126.01, "rdend", 1, 1, 0.5, 0.5, 1)
save_window_.label(216.075, 111.029, "idend", 1, 1, 0.5, 0.5, 1)
save_window_.label(252.187, 72.3935, "cdend", 1, 1, 0.5, 0.5, 1)
}
ocbox_.map("LinearCircuit[0]", 1, 642, 285.3, 477.9)
}
objref ocbox_
//End LinearCircuit[0]

{
xpanel("RunControl", 0)
v_init = -68
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 100
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 100
xvalue("t","t", 2 )
tstop = 100
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.1
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 10
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
screen_update_invl = 0.05
xvalue("Scrn update invl","screen_update_invl", 1,"", 0, 1 )
realtime = 12.14
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(66,210)
}
{
xpanel("forall Ra=global_ra", 0)
global_ra = 100
xvalue("global Ra","global_ra", 1,"set_ra()", 1, 1 )
xpanel(0,558)
}
{
xpanel("Temperature", 0)
celsius = 37
xvalue("celsius","celsius", 1,"", 0, 1 )
xpanel(56,133)
}
objectvar scene_vector_[1]
{doNotify()}


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