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Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)

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Accession:138379
"Coordination of neocortical oscillations has been hypothesized to underlie the "binding" essential to cognitive function. However, the mechanisms that generate neocortical oscillations in physiological frequency bands remain unknown. We hypothesized that interlaminar relations in neocortex would provide multiple intermediate loops that would play particular roles in generating oscillations, adding different dynamics to the network. We simulated networks from sensory neocortex using 9 columns of event-driven rule-based neurons wired according to anatomical data and driven with random white-noise synaptic inputs. ..."
Reference:
1 . Neymotin SA, Lee H, Park E, Fenton AA, Lytton WW (2011) Emergence of physiological oscillation frequencies in a computer model of neocortex. Front Comput Neurosci 5:19 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations; Synchronization; Laminar Connectivity;
Implementer(s): Lytton, William [bill.lytton at downstate.edu]; Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; GabaA; AMPA; NMDA; Gaba; Gaba; Glutamate;
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fdemo
readme.txt
intf6_.mod
misc.mod *
nstim.mod *
stats.mod *
vecst.mod
col.hoc
declist.hoc *
decmat.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
filtutils.hoc
finish_run.hoc
grvec.hoc *
init.hoc *
labels.hoc *
local.hoc *
misc.h
mosinit.hoc
network.hoc
nload.hoc
nqs.hoc *
nqsnet.hoc *
nrnoc.hoc *
params.hoc
python.hoc *
pywrap.hoc *
run.hoc
setup.hoc
simctrl.hoc *
spkts.hoc *
stats.hoc *
syncode.hoc *
xgetargs.hoc *
                            
// $Id: setup.hoc,v 1.25 2006/12/26 22:34:47 billl Exp $
// variables normally controlled by SIMCTRL


// load_file("setup.hoc")
load_file("stdgui.hoc")
show_panel=0
strdef simname, filename, output_file, datestr, uname, comment, section, osname
objref tmpfile,nil,graphItem,sfunc
sfunc = hoc_sf_  // from stdlib.hoc
proc chop () { sfunc.left($s1,sfunc.len($s1)-1) }

tmpfile = new File()
simname = "sim"      // helpful if running multiple simulations simultaneously
runnum = 1           // updated at end of run
uname="mswin_or_MAC" // used if not unix
datestr="unknown_date" // used if not unix
if (unix_mac_pc()==1) {  // true if unix
  system("uname -m",uname)  // keep track of type of machine for byte compatibility
  chop(uname)
  system("date +%y%b%d",datestr)
  chop(datestr) // may prefer to downcase later
}
  sprint(output_file,"data/%s.%02d",datestr,runnum)  // assumes a subdir called data
if (unix_mac_pc()==1) osname = "Linux" else if (unix_mac_pc()==2) { 
  osname = "Mac" } else if (unix_mac_pc()==3) osname = "PC"
printStep = 0.25 // time interval for saving to vector
graph_flag=0
batch_flag=1
xwindows = 0     // can still save but not look without xwindows

// load_file("nrnoc.hoc")

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