Bursting respiratory net: clustered architecture gives large phase diff`s (Fietkiewicz et al 2011)

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Accession:139418
Using a previous model of respiratory rhythm generation, we modified the network architecture such that cells can be segregated into two clusters. Cells within a given cluster burst with smaller phase differences than do cells from different clusters. This may explain the large phase differences seen experimentally, as reported in the paper.
Reference:
1 . Fietkiewicz C, Loparo KA, Wilson CG (2011) Drive latencies in hypoglossal motoneurons indicate developmental change in the brainstem respiratory network. J Neural Eng 8:065011 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting;
Implementer(s):
COMMENT
Slavish transliteration of equation from Purvis & Butera 2005.
Not a remapping of their Ca accum mechanism in a form that would use density parameters.

Cannot be used outside of the context of their model 
(K1 implicitly assumes a particular volume and surface/volume ratio, which 
depend on cell geometry).

In the absence of calcium currents, cai will monoexponentially decay toward 0.
ENDCOMMENT

NEURON {
	SUFFIX cax
	USEION ca READ ica WRITE cai
	RANGE K1, K2
}

UNITS {
	(mM) = (milli/liter)
	(mA) = (milliamp)
	F = (faraday) (coulombs)
}

PARAMETER {
	K1 = 0.02 (mM-cm2/ms-mA)
	K2 = 0.04 (/ms)
	cai0 = 0.0000604 (mM)
}

ASSIGNED {
	 ica (mA/cm2)
}

STATE {
	cai (mM)
}

INITIAL {
	cai = cai0
}

BREAKPOINT {
	SOLVE integrate METHOD derivimplicit
}

DERIVATIVE integrate {
	cai' = -(K1*ica + K2*cai)
}

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