Bursting respiratory net: clustered architecture gives large phase diff`s (Fietkiewicz et al 2011)

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Accession:139418
Using a previous model of respiratory rhythm generation, we modified the network architecture such that cells can be segregated into two clusters. Cells within a given cluster burst with smaller phase differences than do cells from different clusters. This may explain the large phase differences seen experimentally, as reported in the paper.
Reference:
1 . Fietkiewicz C, Loparo KA, Wilson CG (2011) Drive latencies in hypoglossal motoneurons indicate developmental change in the brainstem respiratory network. J Neural Eng 8:065011 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting;
Implementer(s):
TITLE Sodium Potassium Pump

UNITS {
      (molar) = (1/liter)
      (mV) = (millivolts)
      (mA) = (milliamp)
      (mM) = (millimolar)
}

NEURON {
       SUFFIX pump
       USEION k READ ko WRITE ik
       RANGE ipumpmax, kbath
}

PARAMETER {
	  kbath	= 9		 (mM)
	  ko		         (mM)
	  ipumpmax = 0.0005     (mA/cm2)
	  ipump			 (mA/cm2)
}

ASSIGNED {
	 ik	 (mA/cm2)
}

BREAKPOINT {
	   ipump =  ipumpmax/((1+(kbath/ko))^2)
	   if (ipump <=0) {
	     ipump=0
	     }
	   ik = -2*ipump

}


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