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Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
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Accession:
139421
"Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare, OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta. ..."
Reference:
1 .
Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Ketamine Disrupts Theta Modulation of Gamma in a Computer Model of Hippocampus
J Neurosci .
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA3 pyramidal GLU cell;
Hippocampus CA3 interneuron basket GABA cell;
Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s):
I L high threshold;
I A;
I K;
I K,Ca;
Gap Junctions:
Receptor(s):
GabaA;
NMDA;
Glutamate;
Gene(s):
HCN1;
HCN2;
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Oscillations;
Synchronization;
Therapeutics;
Pathophysiology;
Schizophrenia;
Information transfer;
Brain Rhythms;
Implementer(s):
Lazarewicz, Maciej [mlazarew at gmu.edu];
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
Search NeuronDB
for information about:
Hippocampus CA3 pyramidal GLU cell
;
Hippocampus CA3 interneuron basket GABA cell
;
GabaA
;
NMDA
;
Glutamate
;
I L high threshold
;
I A
;
I K
;
I K,Ca
;
Gaba
;
Glutamate
;
Download the displayed file
/
hpcdemo
readme.html
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// $Id: geom.hoc,v 1.1 2009/11/03 22:02:16 samn Exp $
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