Hippocampal CA3 network and circadian regulation (Stanley et al. 2013)

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Accession:142104
This model produces the hippocampal CA3 neural network model used in the paper below. It has two modes of operation, a default mode and a circadian mode. In the circadian mode, parameters are swept through a range of values. This model can be quite easily adapted to produce theta and gamma oscillations, as certain parameter sweeps will reveal (see Figures). BASH scripts interact with GENESIS 2.3 to implement parameter sweeps. The model contains four cell types derived from prior papers. CA3 pyramidal are derived from Traub et al (1991); Basket, stratum oriens (O-LM), and Medial Septal GABAergic (MSG) interneurons are taken from Hajos et al (2004).
Reference:
1 . Stanley DA, Talathi SS, Parekh MB, Cordiner DJ, Zhou J, Mareci TH, Ditto WL, Carney PR (2013) Phase shift in the 24-hour rhythm of hippocampal EEG spiking activity in a rat model of temporal lobe epilepsy. J Neurophysiol 110:1070-86 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus; Medial Septum;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Hippocampus septum medial GABAergic neuron;
Channel(s): I Na,t; I A; I K; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS; MATLAB;
Model Concept(s): Epilepsy; Brain Rhythms; Circadian Rhythms;
Implementer(s): Stanley, David A ;
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; GabaA; AMPA; I Na,t; I A; I K; I h; I K,Ca; I Calcium; Gaba; Glutamate;
function y = wkeep(x,varargin)
%WKEEP  Keep part of a vector or a matrix.
%   For a vector:
%   Y = WKEEP(X,L,OPT) extracts the vector Y 
%   from the vector X. The length of Y is L.
%   If OPT = 'c' ('l' , 'r', respectively), Y is the central
%   (left, right, respectively) part of X.
%   Y = WKEEP(X,L,FIRST) returns the vector X(FIRST:FIRST+L-1).
%
%   Y = WKEEP(X,L) is equivalent to Y = WKEEP(X,L,'c').
%
%   For a matrix:
%   Y = WKEEP(X,S) extracts the central part of the matrix X. 
%   S is the size of Y.
%   Y = WKEEP(X,S,[FIRSTR,FIRSTC]) extracts the submatrix of 
%   matrix X, of size S and starting from X(FIRSTR,FIRSTC).

%   M. Misiti, Y. Misiti, G. Oppenheim, J.M. Poggi 01-May-96.
%   Last Revision: 30-Jul-2007.
%   Copyright 1995-2007 The MathWorks, Inc.
% $Revision: 1.14.4.3 $

% Check arguments.
nbIn = nargin;
msg = nargchk(2,4,nbIn);
if ~isempty(msg)
    error('Wavelet:FunctionInput:NbArg',msg)
end

y = x;
sizeKept = varargin{1}(:)';
nbDIM = length(sizeKept);
if nbDIM<=1
    sx = length(x);
    [first,last,ok] = GetFirstLast(sx,nbDIM,varargin{:});
    if ok , y = y(first(1):last(1)); end
else
    sx = size(x);  
    [first,last,ok] = GetFirstLast(sx,nbDIM,varargin{:});
    if ok , y = y(first(1):last(1),first(2):last(2)); end
end


%----------------------------------------------------------------------------%
%Internal Function(s)
%----------------------------------------------------------------------------%
function [first,last,ok] = GetFirstLast(sx,nbDIM,varargin)

begInd = ones(1,nbDIM);
oneDIM = isequal(begInd,1);
s = varargin{1}(:)';
if ~oneDIM
    K  = find(s>sx);
    s(K) = sx(K);
    ok = ~(any(s < 0) || (any(s~=fix(s))));
else
    ok = (s>=0) && (s<sx) && (s == fix(s)); %#ok<BDSCI>
end
if ok==0 , first = begInd; last = s; return; end

nbarg = length(varargin);
if nbarg<2, o = 'c'; else o = lower(varargin{2}); end

err = 0;
if ischar(o(1))
    switch o(1)
        case 'c'
            d = (sx-s)/2;
            if nbarg<3
                if length(o)>1 , side = o(2:end); else side = 'l'; end
            else
                side = varargin{3};
            end
            if oneDIM
                [first,last] = GetFirst1D(side,sx,d);
            else
                if length(side)<2 , side(2) = 0; end
                first = zeros(1,2);
                last  = zeros(1,2);
                for k = 1:2
                    [first(k),last(k)] = GetFirst1D(side(k),sx(k),d(k));
                end
            end

        case {'l','u'} , first = begInd; last = s;
        case {'r','d'} , first = sx-s+1; last = sx;
        otherwise      , err = 1;
    end
else
    first = o; last = first+s-1;
    if ~isequal(first,fix(first)) || any(first<1) || any(last>sx)
        err = 1;
    end
end
if err
    errargt(mfilename,'invalid argument','msg');
    error('Wavelet:Invalid_ArgVal_Or_ArgType', ...
        'Invalid argument value.');
end
%----------------------------------------------------------------------------%
function [first,last] = GetFirst1D(side,s,d)

switch side
  case {'u','l','0',0} , first = 1+floor(d); last = s-ceil(d);
  case {'d','r','1',1} , first = 1+ceil(d);  last = s-floor(d);
  otherwise    , first = 1+floor(d); last = s-ceil(d);  % Default is left side
end
%----------------------------------------------------------------------------%

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