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ClC-2 channels regulate neuronal excitability, not intracellular Cl- levels (Ratte & Prescott 2011)
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"The model is for a generic, single compartment neuron with multiple ion currents. The most notable mechanisms include ClC-2 (a rectifying chloride-leak channel) and KCC2 (potassium chloride co-transporter 2). A significant feature of the model is that it tracks intracellular chloride concentration. Moreover, the GABA-A receptor is modeled as passing both chloride and bicarbonate ions, which is important for proper calculation of the GABA reversal potential. Ornstein-Unlenbeck processes to simulate synaptic inhibition and excitation are also included."
Ratté S, Prescott SA (2011) ClC-2 channels regulate neuronal excitability, not intracellular chloride levels.
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Neuron or other electrically excitable cell;
I Cl, leak;
Prescott, Steven [steve.prescott at sickkids.ca]];
for information about:
I Cl, leak
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