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Phase response curve of a globus pallidal neuron (Fujita et al. 2011)

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Accession:143100
We investigated how changes in ionic conductances alter the phase response curve (PRC) of a globus pallidal (GP) neuron and stability of a synchronous activity of a GP network, using a single-compartmental conductance-based neuron model. The results showed the PRC and the stability were influenced by changes in the persistent sodium current, the Kv3 potassium, the M-type potassium and the calcium-dependent potassium current.
Reference:
1 . Fujita T, Fukai T, Kitano K (2012) Influences of membrane properties on phase response curve and synchronization stability in a model globus pallidus neuron. J Comput Neurosci 32:539-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s): I Na,p; I Na,t; I A; I M; I h; I K,Ca; I Calcium; I A, slow; KCNQ1;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Ions;
Simulation Environment: NEURON;
Model Concept(s): Synchronization; Parkinson's; Phase Response Curves;
Implementer(s): Kitano, Katsunori [kkt23219 at is.ritsumei.ac.jp];
Search NeuronDB for information about:  I Na,p; I Na,t; I A; I M; I h; I K,Ca; I Calcium; I A, slow; KCNQ1; Ions; 
TITLE calcium-dependent potassium (SK) channel for GPe neuron

COMMENT
 modeled by Gunay et al., 2008
 implemented in NEURON by Kitano, 2011
ENDCOMMENT

UNITS {
 (mV) = (millivolt)
 (mA) = (milliamp)
 (mM) = (milli/liter)
}

NEURON {
 SUFFIX SK
 USEION ca READ cai
 USEION k READ ek WRITE ik
 RANGE gmax, iSK
}

PARAMETER {
 v (mV)
 dt (ms)
 gmax  = 0.001 (mho/cm2)
 iSK  = 0.0 (mA/cm2)
 cai (mM)
 ek (mV)

 ECh = 0.00035 (mM)
 HCoeff = 4.6
 Ca_sat = 0.005 (mM)
 tau_m0 = 4.0 (ms)
 tau_m1 = 76.0 (ms)
}

STATE {
 m
}

ASSIGNED { 
 ik (mA/cm2)
 minf
 taum (ms)
}

BREAKPOINT {
 SOLVE states METHOD cnexp
 ik  = gmax*m*(v-ek)
 iSK = ik
}

UNITSOFF

INITIAL {
 settables(cai)
 m = minf
}

DERIVATIVE states {  
 settables(cai)
 m' = (minf - m)/taum
}

PROCEDURE settables(cai) { LOCAL can, can0
	can = pow(cai*1000, HCoeff)
	can0 = pow(ECh*1000, HCoeff)
	minf = can/(can + can0)
	if(cai < Ca_sat){
	 taum = tau_m1 - cai*(tau_m1 - tau_m0)/Ca_sat
	} else {
	 taum = tau_m0
	}
}

UNITSON

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