Phase response curve of a globus pallidal neuron (Fujita et al. 2011)

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Accession:143100
We investigated how changes in ionic conductances alter the phase response curve (PRC) of a globus pallidal (GP) neuron and stability of a synchronous activity of a GP network, using a single-compartmental conductance-based neuron model. The results showed the PRC and the stability were influenced by changes in the persistent sodium current, the Kv3 potassium, the M-type potassium and the calcium-dependent potassium current.
Reference:
1 . Fujita T, Fukai T, Kitano K (2012) Influences of membrane properties on phase response curve and synchronization stability in a model globus pallidus neuron. J Comput Neurosci 32:539-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s): I Na,p; I Na,t; I A; I M; I h; I K,Ca; I Calcium; I A, slow; KCNQ1;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Ions;
Simulation Environment: NEURON;
Model Concept(s): Synchronization; Parkinson's; Phase Response Curves;
Implementer(s): Kitano, Katsunori [kkt23219 at is.ritsumei.ac.jp];
Search NeuronDB for information about:  I Na,p; I Na,t; I A; I M; I h; I K,Ca; I Calcium; I A, slow; KCNQ1; Ions;
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save_window_.addvar("soma.iKv2_Kv2( 0.5 )", 3, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.iKv4f_Kv4f( 0.5 )", 3, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.iKv4s_Kv4s( 0.5 )", 3, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.iKCNQ_KCNQ( 0.5 )", 1, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.iCaH_CaH( 0.5 )", 5, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.iHCN_HCN( 0.5 )", 7, 1, 0.8, 0.9, 2)
save_window_.addvar("soma.iSK_SK( 0.5 )", 4, 1, 0.8, 0.9, 2)
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objectvar scene_vector_[1]
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