ModelDB: CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)

CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)

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Accession:144392

NEURON mod files from the paper: Shah et al., 2011. In this study, using a combination of electrophysiology and computational modelling, we show that these channels selectively influence peri-somatic but not dendritic post-synaptic excitatory synaptic potential (EPSP) integration in CA1 pyramidal cells. This may be important for their relative contributions to physiological processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy.
Reference:
1 . Shah MM, Migliore M, Brown DA (2011) Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons. J Physiol 589:6029-38 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I A; I K; I M; I h; I_AHP;
Gap Junctions:
Receptor(s):	AMPA;
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	NEURON;
Model Concept(s):	Synaptic Integration;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];