Inferior Olive, subthreshold oscillations (Torben-Nielsen, Segev, Yarom 2012)

 Download zip file 
Help downloading and running models
Accession:144502
The Inferior Olive is a brain structure in which neurons are solely connected to each other through gap-junctions. Its behavior is characterized by spontaneous subthreshold oscillation, frequency changes in the subthreshold oscillation, stable phase differences between neurons, and propagating waves of activity. Our model based on actual IO topology can reproduce these behaviors and provides a mechanistic explanation thereof.
Reference:
1 . Torben-Nielsen B, Segev I, Yarom Y (2012) The generation of phase differences and frequency changes in a network model of inferior olive subthreshold oscillations. PLoS Comput Biol 8:e1002580 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Inferior olive neuron;
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Oscillations;
Implementer(s): Torben-Nielsen, Ben [btorbennielsen at gmail.com];
Search NeuronDB for information about:  I T low threshold; Gaba;
NEURON {
	POINT_PROCESS gap2
	NONSPECIFIC_CURRENT i
	RANGE i, g,t1,t2,g1,g2
	POINTER vgap	
}
PARAMETER {
	v (millivolt)
	g = 0 (nanosiemens) :1 (nanosiemens) : 1nS = 1000 pS
	g1=0 (nanosiemens)
	g2=0 (nanosiemens)
	t1=0 (milliseconds)
	t2=0 (milliseconds)
}
ASSIGNED {
	i (nanoamp)
	vgap (millivolt)
}
BREAKPOINT {
	if(t < t1) {
	     g = g1
	     :printf("1st IF:: t=%g, g=%g\n",t,g)
	}
	if( (t > t1) && (t < t2)) {
	    g = g2
	    :printf("2nd IF:: t=%g, g=%g\n",t,g)
	}
	if(t > t2) {
	    g = g1
	    :printf("3rd IF:: t=%g, g=%g\n",t,g)
	}
	i = (v - vgap)*g*(0.001)
}

Loading data, please wait...