ModelDB: Inferior Olive, subthreshold oscillations (Torben-Nielsen, Segev, Yarom 2012)

Inferior Olive, subthreshold oscillations (Torben-Nielsen, Segev, Yarom 2012)

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Accession:144502

The Inferior Olive is a brain structure in which neurons are solely connected to each other through gap-junctions. Its behavior is characterized by spontaneous subthreshold oscillation, frequency changes in the subthreshold oscillation, stable phase differences between neurons, and propagating waves of activity. Our model based on actual IO topology can reproduce these behaviors and provides a mechanistic explanation thereof.
Reference:
1 . Torben-Nielsen B, Segev I, Yarom Y (2012) The generation of phase differences and frequency changes in a network model of inferior olive subthreshold oscillations. PLoS Comput Biol 8:e1002580 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):	Inferior olive neuron;
Channel(s):	I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):	Gaba;
Simulation Environment:	NEURON;
Model Concept(s):	Oscillations;
Implementer(s):	Torben-Nielsen, Ben [btorbennielsen at gmail.com];