Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985)

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Accession:144520
"Equations have been developed to describe cardiac action potentials and pacemaker activity. The model takes account of extensive developments in experimental work ..."
Reference:
1 . DiFrancesco D, Noble D (1985) A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond B Biol Sci 307:353-98 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Cardiac ventricular cell;
Channel(s): I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s): HCN4;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Gannier, Francois [francois.gannier at univ-tours.fr];
Search NeuronDB for information about:  I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;
TITLE Time-independent (delayed) K+ current Ik1
COMMENT
	modified From DiFrancesco & Noble 1985 Phil Trans R Soc Lond 307:353-398 
    modified for Neuron by FE GANNIER
	francois.gannier@univ-tours.fr (University of TOURS)
ENDCOMMENT
INCLUDE "Unit.inc"
INCLUDE "Volume.inc"
NEURON {
	SUFFIX ik1
	USEION k READ ek, ko WRITE ik
	RANGE g, ik
}

PARAMETER {
	g = 920		(uS)
	Km1 = 210	(mM)
}

ASSIGNED {
	v (mV)
	celsius (degC) : 37
	ik (mA/cm2)
	minf 
	mtau (ms)  
	ek (mV)
	ko (mM)
	ki (mM)
}

LOCAL RT
INITIAL {
	RT = (1000)*R*(273.15+celsius)
}

BREAKPOINT { 
	ik = (1e-06)* g/S * (ko/(ko + Km1))*((v-ek)/(1 + exp((v - ek + 10)*2*F/RT)))
}

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