STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)

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Accession:144523
"... We use a conductance-based model of a CN neuron to study the effect of the regularity of Purkinje cell spiking on CN neuron activity. We find that increasing the irregularity of Purkinje cell activity accelerates the CN neuron spike rate and that the mechanism of this recoding of input irregularity as output spike rate depends on the number of Purkinje cells converging onto a CN neuron. ..."
Reference:
1 . Luthman J, Hoebeek FE, Maex R, Davey N, Adams R, De Zeeuw CI, Steuber V (2011) STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron. Cerebellum 10:667-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum deep nucleus neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Temporal Pattern Generation; Short-term Synaptic Plasticity;
Implementer(s): Luthman, Johannes [jwluthman at gmail.com];
Search NeuronDB for information about:  I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I K,Ca;
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LuthmanEtAl2011
readme.txt
CaConc.mod *
CaHVA.mod *
CalConc.mod *
CaLVA.mod *
DCNsyn.mod *
DCNsynGABA.mod *
DCNsynNMDA.mod *
fKdr.mod *
GammaStim.mod *
h.mod *
NaF.mod *
NaP.mod *
pasDCN.mod *
SK.mod *
sKdr.mod *
TNC.mod *
DCN_mechs.hoc
DCN_morph.hoc *
DCN_recording.hoc
DCN_run.hoc
DCN_simulation.hoc
mosinit.hoc
OutputDCN_soma_1s_ap.dat
OutputDCN_soma_1s_time.dat
OutputDCN_soma_1s_trace.dat
                            
COMMENT
    This mech is based on the "built-in" pas channel from NEURON 6.1.
    Johannes Luthman has taken it to be used for the DCN neuron model
    and made the following modifications: 
    - g has been renamed gbar in accordance with the other DCN channels
    - e has been changed from -70 to -66 mV
    
ENDCOMMENT 

TITLE passive membrane channel

NEURON {
	SUFFIX pasDCN
	NONSPECIFIC_CURRENT i
	RANGE gbar, e, i
}

UNITS {
	(mV) = (millivolt)
	(mA) = (milliamp)
	(S) = (siemens)
}

PARAMETER {
	gbar = .001	(S/cm2)	<0,1e9>
	e = -66	(mV) : the reversal potential can be given as a PARAMETER rather
	    : than being ASSIGNed from hoc as for CaLVA and other channels using
	    : self-defined reversal potential names ("e" is recognized by hoc, but not "ecal" etc)
}

ASSIGNED {
    v (mV)  
    i (mA/cm2)
}

BREAKPOINT {
	i = gbar * (v - e)
}

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