Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)

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Accession:144579
Using the Traub et al (2005) model of the cortex we determined how 33 synaptic strength parameters control gamma oscillations. We used fractional factorial design to reduce the number of runs required to 4096. We found an expected multiplicative interaction between parameters.
Reference:
1 . Chambers JD, Bethwaite B, Diamond NT, Peachey T, Abramson D, Petrou S, Thomas EA (2012) Parametric computation predicts a multiplicative interaction between synaptic strength parameters that control gamma oscillations. Front Comput Neurosci 6:53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Axon; Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s): I A; I K; I K,leak; I K,Ca; I Calcium; I_K,Na;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Parameter sensitivity;
Implementer(s): Thomas, Evan [evan at evan-thomas.net]; Chambers, Jordan [jordandchambers at gmail.com];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; GabaA; AMPA; NMDA; I A; I K; I K,leak; I K,Ca; I Calcium; I_K,Na; Gaba; Glutamate;
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FRBGamma
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alphasyndiffeq.mod *
alphasynkin.mod *
alphasynkint.mod *
ampa.mod *
ar.mod *
cad.mod *
cal.mod *
cat.mod *
cat_a.mod *
gabaa.mod *
iclamp_const.mod *
k2.mod *
ka.mod *
ka_ib.mod *
kahp.mod *
kahp_deeppyr.mod *
kahp_slower.mod *
kc.mod *
kc_fast.mod *
kdr.mod *
kdr_fs.mod *
km.mod *
naf.mod
naf_tcr.mod *
naf2.mod
nap.mod
napf.mod *
napf_spinstell.mod *
napf_tcr.mod *
par_ggap.mod *
pulsesyn.mod *
rampsyn.mod *
rand.mod *
ri.mod
traub_nmda.mod *
                            
TITLE Potasium dr type current for fast-spiking (FS) interneurons for RD Traub et al 2005

COMMENT
	Slight modification in minf for Traub et al 2005 from version:
	Potasium dr type current for RD Traub, J Neurophysiol 89:909-921, 2003
	Implemented by Maciej Lazarewicz 2003 (mlazarew@seas.upenn.edu)

ENDCOMMENT

INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) }

UNITS { 
	(mV) = (millivolt) 
	(mA) = (milliamp) 
} 

NEURON { 
	SUFFIX kdr_fs
	USEION k READ ek WRITE ik
	RANGE gbar, ik, m, mtau, minf
}

PARAMETER { 
	gbar = 0.0 	(mho/cm2)
	v (mV) ek 		(mV)  
}
 
ASSIGNED { 
	ik 		(mA/cm2) 
	minf 		(1)
	mtau 		(ms) 
}
 
STATE {
	m
}

BREAKPOINT { 
	SOLVE states METHOD cnexp
	ik = gbar * m * m * m * m * ( v - ek ) 
}
 
INITIAL { 
	settables(v) 
:	m = minf
	m = 0
}
 
DERIVATIVE states { 
	settables(v) 
	m' = ( minf - m ) / mtau 
}

UNITSOFF 

PROCEDURE settables(v(mV)) { 
	TABLE minf, mtau FROM -120 TO 40 WITH 641

	minf  = 1.0 / ( 1.0 + exp( ( -v - 27.0 ) / 11.5 ) )
	if( v <= -10.0 ) {
		mtau = 0.25 + 4.35 * exp( ( v + 10.0 ) / 10.0 )
	}else{
		mtau = 0.25 + 4.35 * exp( ( -v - 10.0 ) / 10.0 )
	}
}

UNITSON

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