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A fast model of voltage-dependent NMDA Receptors (Moradi et al. 2013)
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These are two or triple-exponential models of the voltage-dependent NMDA receptors. Conductance of these receptors increase voltage-dependently with a "Hodgkin and Huxley-type" gating style that is also depending on glutamate-binding. Time course of the gating of these receptors in response to glutamate are also changing voltage-dependently. Temperature sensitivity and desensitization of these receptor are also taken into account. Three previous kinetic models that are able to simulate the voltage-dependence of the NMDARs are also imported to the NMODL. These models are not temperature sensitive. These models are compatible with the "event delivery system" of NEURON. Parameters that are reported in our paper are applicable to CA1 pyramidal cell dendrites.
Moradi K, Moradi K, Ganjkhani M, Hajihasani M, Gharibzadeh S, Kaka G (2013) A fast model of voltage-dependent NMDA receptors.
J Comput Neurosci
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Hippocampus CA1 pyramidal GLU cell;
Ion Channel Kinetics;
Long-term Synaptic Plasticity;
Moradi, Keivan [k.moradi at gmail.com];
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Hippocampus CA1 pyramidal GLU cell
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