Olfactory bulb mitral cell gap junction NN model: burst firing and synchrony (O`Connor et al. 2012)

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Accession:146030
In a network of 6 mitral cells connected by gap junction in the apical dendrite tuft, continuous current injections of 0.06 nA are injected into 20 locations in the apical tufts of two of the mitral cells. The current injections into one of the cells starts 10 ms after the other to generate asynchronous firing in the cells (Migliore et al. 2005 protocol). Firing of the cells is asynchronous for the first 120 ms. However after the burst firing phase is completed the firing in all cells becomes synchronous.
Reference:
1 . O'Connor S, Angelo K, Jacob TJC (2012) Burst firing versus synchrony in a gap junction connected olfactory bulb mitral cell network model. 6:75. Frontiers in Computational Neuroscience 6:75:1-18
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell;
Channel(s): I Na,t; I L high threshold; I A; I K; I K,Ca;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Oscillations; Synchronization; Active Dendrites; Influence of Dendritic Geometry; Calcium dynamics; Olfaction;
Implementer(s):
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I Na,t; I L high threshold; I A; I K; I K,Ca;
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oconnoretal2012
README
AMPA.mod
Ca_mit_conc_ChannelML.mod
CurrentClampExt.mod
KA_ChannelML.mod
KCa3_ChannelML_new.mod
Kdr_ChannelML.mod
LCa3_mit_usb_ChannelML.mod
LeakConductance.mod
NaxSH0_ChannelML.mod
NaxSH10_ChannelML.mod
SynForRndSpike.mod
Cell1.hoc
Cell2.hoc
Cell3.hoc
Cell4.hoc
Cell5.hoc
Cell6.hoc
cellCheck.hoc
CellPositions.dat
ElectricalInputs.dat
gap.hoc
init.hoc
mosinit.hoc *
nCtools.hoc
NetworkConnections.dat
regenerateMods
simulation.props
                            
COMMENT

   **************************************************
   File generated by: neuroConstruct v1.3.8 
   **************************************************

   This file holds the implementation in NEURON of the Cell Mechanism:
   AMPA (Type: Synaptic mechanism, Model: File Based Membrane Mechanism)

   with parameters: 

ENDCOMMENT

TITLE AMPA receptors with 3-state DCO kinetic scheme
COMMENT
Author: Elena Saftenku, 2003
ENDCOMMENT
NEURON {
	POINT_PROCESS AMPA
	POINTER pglu
	NONSPECIFIC_CURRENT iampa
	RANGE  Erev, RelProb 
	RANGE gampa,gbarampa,ko,kd,kr,kb,kc,Ro
	}
UNITS {
	(nA) = (nanoamp)
	(mV) = (millivolt)
	(umho) = (micromho)
	(mM) = (milli/liter)
	(pS) = (picosiemens)
}
PARAMETER {	
	gbarampa	= 1200   (pS)					 
	ko	= 25.39 (/ms) 				
	kc	= 4	(/ms)				
	kd	= 5.11 (/ms) 		
	kr	= 0.065(/ms)			
      kb    =0.44 (mM) 
	Erev	= 0	(mV)
      RelProb=0.46
}
ASSIGNED {
	v (mV)		
	iampa (nA)	:current	
	gampa  (pS)	: conductance	
      pglu(mM): glutamate concentration
Ro	: receptor occupancy
celsius  (degC)
}
STATE {	
	C
	O
	D
}
INITIAL {
	C=1
	O=0
	D=0	
}

BREAKPOINT {
	SOLVE states METHOD derivimplicit
	Ro=(pglu^2+ (kb^2+2*kb*pglu)*(O+D))/(pglu+kb)^2
       gampa = gbarampa *  O * RelProb
	iampa = (1e-6) * gampa * (v - Erev)
}

DERIVATIVE states {
	LOCAL kon,kdn,Q10
Q10 = 2^((celsius-37(degC))/10(degC))
kdn = kd*pglu^2/(pglu+kb)^2
kon = ko*pglu^2/(pglu+kb)^2	
C'=Q10*(-(kdn+kon)*C+kr*D+kc*O)
D'=Q10*(-kr*D+kdn*C)
O'=Q10*(-kc*O+kon*C)	
}


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