Olfactory bulb mitral cell gap junction NN model: burst firing and synchrony (O`Connor et al. 2012)

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Accession:146030
In a network of 6 mitral cells connected by gap junction in the apical dendrite tuft, continuous current injections of 0.06 nA are injected into 20 locations in the apical tufts of two of the mitral cells. The current injections into one of the cells starts 10 ms after the other to generate asynchronous firing in the cells (Migliore et al. 2005 protocol). Firing of the cells is asynchronous for the first 120 ms. However after the burst firing phase is completed the firing in all cells becomes synchronous.
Reference:
1 . O'Connor S, Angelo K, Jacob TJC (2012) Burst firing versus synchrony in a gap junction connected olfactory bulb mitral cell network model. 6:75. Frontiers in Computational Neuroscience 6:75:1-18
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell;
Channel(s): I Na,t; I L high threshold; I A; I K; I K,Ca;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Oscillations; Synchronization; Active Dendrites; Influence of Dendritic Geometry; Calcium dynamics; Olfaction;
Implementer(s):
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I Na,t; I L high threshold; I A; I K; I K,Ca;
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oconnoretal2012
README
AMPA.mod
Ca_mit_conc_ChannelML.mod
CurrentClampExt.mod
KA_ChannelML.mod
KCa3_ChannelML_new.mod
Kdr_ChannelML.mod
LCa3_mit_usb_ChannelML.mod
LeakConductance.mod
NaxSH0_ChannelML.mod
NaxSH10_ChannelML.mod
SynForRndSpike.mod
Cell1.hoc
Cell2.hoc
Cell3.hoc
Cell4.hoc
Cell5.hoc
Cell6.hoc
cellCheck.hoc
CellPositions.dat
ElectricalInputs.dat
gap.hoc
init.hoc
mosinit.hoc *
nCtools.hoc
NetworkConnections.dat
regenerateMods
simulation.props
                            
COMMENT

This is based on stim.mod from the NEURON source code. Extended by Padraig Gleeson for
use in neuroConstruct.

The original IClamp object in that has been extended to allow continuous
repetition of the current pulse, as is possible with the GENESIS pulsegen
object (http://www.genesis-sim.org/GENESIS/gum-tutorials/beeman/Hyperdoc/Manual-26.html#ss26.49). 
Note: that object allows up to two individual pulses to be applied 
and repeated, but it's just as easy to add a second Input to a cell group
in neuroConstruct, so only one pulse is supported here.


Original comment in stim.mod:

Since this is an electrode current, positive values of i depolarize the cell
and in the presence of the extracellular mechanism there will be a change
in vext since i is not a transmembrane current but a current injected
directly to the inside of the cell.

ENDCOMMENT

NEURON {

    POINT_PROCESS CurrentClampExt
    RANGE del, dur, amp, repeat, i
    ELECTRODE_CURRENT i
    
}

UNITS {

    (nA) = (nanoamp)
    
}


PARAMETER {

    del (ms)
    dur (ms)    <0,1e9>
    amp (nA)
    repeat = 0
    
}

ASSIGNED { 
    
    i (nA) 
    
}

INITIAL {

    i = 0
    
}

BREAKPOINT {

    LOCAL shiftedTime, beginNextCycle
    
    shiftedTime = t
    
    at_time(del)
    at_time(del+dur)
    
    if (repeat == 1)
    {
        beginNextCycle = 0
        
        while (shiftedTime > del + dur)
        {
            shiftedTime = shiftedTime - (del + dur)
            beginNextCycle = beginNextCycle + (del + dur)
        }
        
        at_time(beginNextCycle + del)       ? to inform CVODE about a future discontinuity
        at_time(beginNextCycle + del+dur)
    }

    if (shiftedTime < del + dur && shiftedTime >= del) {
        i = amp
    }else{
        i = 0
    }
    
    
}

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