KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)

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The output of the cerebellum to the motor axis of the central nervous system is orchestrated mainly by synaptic inputs and intrinsic pacemaker activity of deep cerebellar nuclear (DCN) projection neurons. Herein, we demonstrate that the soma of these cells is enriched with KV1 channels produced by mandatory multi-merization of KV1.1, 1.2 alpha andKV beta2 subunits. Being constitutively active, the K+ current (IKV1) mediated by these channels stabilizes the rate and regulates the temporal precision of self-sustained firing of these neurons. ... Through the use of multi-compartmental modelling and ... the physiological significance of the described functions for processing and communication of information from the lateral DCN to thalamic relay nuclei is established.
1 . Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO (2013) A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol 591:1771-91 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum deep nucleus neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I CAN; I_Ks;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Kv1.1 KCNA1; Kv1.2 KCNA2;
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models; Intrinsic plasticity; Rebound firing;
Implementer(s): Steuber, Volker [v.steuber at herts.ac.uk]; Luthman, Johannes [jwluthman at gmail.com];
Search NeuronDB for information about:  AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I CAN; I_Ks;
CaConc.mod *
CaHVA.mod *
CalConc.mod *
CaLVA.mod *
DCNsyn.mod *
DCNsynGABA.mod *
DCNsynNMDA.mod *
fKdr.mod *
GammaStim.mod *
h.mod *
Ifluct8.mod *
NaF.mod *
NaP.mod *
pasDCN.mod *
SK.mod *
sKdr.mod *
TNC.mod *
DCN_mechs1.hoc *
DCN_morph.hoc *
TITLE Intracellular calcium concentration in deep cerebellar nucleus (DCN) neuron
    This mechanism keeps track of intracellular calcium entering the cell through
    the CaHVA channel. The calcium concentration is for a hypothetical shell
    below the membrane of the cell, and affects the conductance level of the SK.mod
    channel mechanism. In addition, it affects the conductance of the CaHVA channel
    which uses the GHK equation to calculate current flow.
    Translated from GENESIS by Johannes Luthman and Volker Steuber.

    SUFFIX CaConc
    USEION ca READ ica WRITE cai
    RANGE cai, kCa, depth
    GLOBAL tauCa

    (molar) = (1 / liter)
    (mM) = (millimolar)
    (mV) = (millivolt)
    (mA) = (milliamp)
    PI = (pi) (1)

    : qdeltat has been skipped here and is used via the division of this NMODL's
    : tauCa when it's inserted (in hoc).

    : kCa in the following is given for the soma and shall be adjusted
    : from hoc when the CaConc model is inserted in a dendrite: 1.04e-6
    : in the dendritic compartments units. kCa is here given as 1 / coulombs
    : instead of moles / coulomb as in the GENESIS code since mole
    : in NEURON simply equals the number 6.022 * 10e23
    kCa = 3.45e-7 (1/coulomb)
    tauCa = 70 (ms)
    caiBase = 50e-6 (mM) : the assumed resting level of intracellular calcium
    depth = 0.2 (micron)

    C (kilo / m3 / s)
    D (kilo / m3 / s)
    ica (mA/cm2)

    cai (mM)

    cai = caiBase

    SOLVE states METHOD cnexp

    C = (cai - caiBase) / tauCa
	D = - kCa / depth * ica * (1e4)
    cai' = D - C

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