KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:150024
The output of the cerebellum to the motor axis of the central nervous system is orchestrated mainly by synaptic inputs and intrinsic pacemaker activity of deep cerebellar nuclear (DCN) projection neurons. Herein, we demonstrate that the soma of these cells is enriched with KV1 channels produced by mandatory multi-merization of KV1.1, 1.2 alpha andKV beta2 subunits. Being constitutively active, the K+ current (IKV1) mediated by these channels stabilizes the rate and regulates the temporal precision of self-sustained firing of these neurons. ... Through the use of multi-compartmental modelling and ... the physiological significance of the described functions for processing and communication of information from the lateral DCN to thalamic relay nuclei is established.
Reference:
1 . Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO (2013) A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol 591:1771-91 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum deep nucleus neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I CAN; I_Ks;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Kv1.1 KCNA1; Kv1.2 KCNA2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models; Intrinsic plasticity; Rebound firing;
Implementer(s): Steuber, Volker [v.steuber at herts.ac.uk]; Luthman, Johannes [jwluthman at gmail.com];
Search NeuronDB for information about:  AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I h; I CAN; I_Ks;
/
CNModel_May2013
readme.txt
CaConc.mod *
CaHVA.mod *
CalConc.mod *
CaLVA.mod *
DCNsyn.mod *
DCNsynGABA.mod *
DCNsynNMDA.mod *
fKdr.mod *
GammaStim.mod *
h.mod *
Ifluct8.mod *
NaF.mod *
NaP.mod *
pasDCN.mod *
SK.mod *
sKdr.mod *
TNC.mod *
DCN_cip_axis_main.hoc
DCN_cip_fi_main.hoc
DCN_mechs1.hoc *
DCN_mechs2.hoc
DCN_morph.hoc *
DCN_params.hoc
DCN_params_axis.hoc
DCN_params_fi_init.hoc
DCN_params_rebound.hoc
DCN_rebound_main.hoc
DCN_recording.hoc
DCN_spontact_loop_main.hoc
                            
TITLE h current of deep cerebellar nucleus (DCN) neuron
COMMENT
    Translated from GENESIS by Johannes Luthman and Volker Steuber.
ENDCOMMENT 

NEURON { 
	SUFFIX h
	NONSPECIFIC_CURRENT ih
	RANGE gbar, ih, eh, m
	GLOBAL qdeltat
} 
 
UNITS { 
	(mA) = (milliamp) 
	(mV) = (millivolt) 
} 
 
PARAMETER { 
    qdeltat = 1
    gbar = 1e-5 (siemens/cm2)
} 

ASSIGNED {
	v (mV)
	ih (mA/cm2) 
	eh (mV)
	minf
	taum (ms)
} 
 
STATE {
	m
} 

INITIAL { 
    rate(v) 
	taum = 400 / qdeltat
    m = minf 
} 
 
BREAKPOINT { 
    SOLVE states METHOD cnexp 
	ih = gbar * m * m * (v - eh)
} 
 
DERIVATIVE states { 
	rate(v) 
	m' = (minf - m) / taum 
} 

PROCEDURE rate(v(mV)) {
	TABLE minf FROM -150 TO 100 WITH 300 
	minf = 1 / (1 + exp((v + 80) / 5))
}

Loading data, please wait...