Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)

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Accession:150284
"… We present a new event-driven algorithm to synchronize different neuronal models, which decreases computational time and avoids superfluous synchronizations. The algorithm is implemented in the TimeScales framework. We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum. The model comprises over a thousand dendritic spines, where the electrical model interacts with the respective instances of a biochemical model. Our results show that a multiscale model is able to exhibit changes of synaptic plasticity as a result of the interaction between electrical and biochemical signaling. …"
Reference:
1 . Mattioni M, Le Novère N (2013) Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum. PLoS One 8:e66811 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,p; I Na,t; I T low threshold; I A; I K,Ca; I CAN; I Calcium; I A, slow; I Krp; I R; I Q;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.2 KCND2; Kv1.2 KCNA2; Cav1.3 CACNA1D; Cav1.2 CACNA1C; Kv2.1 KCNB1;
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Synaptic Plasticity; Signaling pathways; Calcium dynamics; Multiscale;
Implementer(s): Mattioni, Michele [mattioni at ebi.ac.uk];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; I Na,p; I Na,t; I T low threshold; I A; I K,Ca; I CAN; I Calcium; I A, slow; I Krp; I R; I Q;
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        <p>This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2008 The BioModels Team.
        
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        <a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&amp;pubmedid=16381960" target="_blank"> Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.</a>
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          <bvar>
            <ci> cA </ci>
          </bvar>
          <bvar>
            <ci> cB </ci>
          </bvar>
          <bvar>
            <ci> species_v_22 </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> species_v_22 </ci>
              <ci> kTR </ci>
            </apply>
            <apply>
              <power/>
              <apply>
                <times/>
                <ci> cA </ci>
                <ci> cB </ci>
              </apply>
              <apply>
                <divide/>
                <cn> 1 </cn>
                <cn> 2 </cn>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
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      <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <ci> kTR </ci>
          </bvar>
          <bvar>
            <ci> cA </ci>
          </bvar>
          <bvar>
            <ci> cC </ci>
          </bvar>
          <bvar>
            <ci> species_v_23 </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> species_v_23 </ci>
              <ci> kTR </ci>
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            <apply>
              <power/>
              <apply>
                <times/>
                <ci> cA </ci>
                <ci> cC </ci>
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              <apply>
                <divide/>
                <cn> 1 </cn>
                <cn> 2 </cn>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
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      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> kTR </ci>
          </bvar>
          <bvar>
            <ci> cA </ci>
          </bvar>
          <bvar>
            <ci> cB </ci>
          </bvar>
          <bvar>
            <ci> cC </ci>
          </bvar>
          <bvar>
            <ci> species_v_28 </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> species_v_28 </ci>
              <ci> kTR </ci>
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            <apply>
              <power/>
              <apply>
                <times/>
                <ci> cA </ci>
                <ci> cB </ci>
                <ci> cC </ci>
              </apply>
              <apply>
                <divide/>
                <cn> 1 </cn>
                <cn> 2 </cn>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
    <functionDefinition id="function_22" metaid="metaid_0000024" name="function_4_Transition camT_ca3_ABD to camR_ca3_ABD">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> kTR </ci>
          </bvar>
          <bvar>
            <ci> cA </ci>
          </bvar>
          <bvar>
            <ci> cB </ci>
          </bvar>
          <bvar>
            <ci> cD </ci>
          </bvar>
          <bvar>
            <ci> species_v_29 </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> species_v_29 </ci>
              <ci> kTR </ci>
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            <apply>
              <power/>
              <apply>
                <times/>
                <ci> cA </ci>
                <ci> cB </ci>
                <ci> cD </ci>
              </apply>
              <apply>
                <divide/>
                <cn> 1 </cn>
                <cn> 2 </cn>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
    <functionDefinition id="function_23" metaid="metaid_0000025" name="function_4_Transition camT_ca3_ACD to camR_ca3_ACD">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> kTR </ci>
          </bvar>
          <bvar>
            <ci> cA </ci>
          </bvar>
          <bvar>
            <ci> cC </ci>
          </bvar>
          <bvar>
            <ci> cD </ci>
          </bvar>
          <bvar>
            <ci> species_v_30 </ci>
          </bvar>
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            <divide/>
            <apply>
              <times/>
              <ci> species_v_30 </ci>
              <ci> kTR </ci>
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            <apply>
              <power/>
              <apply>
                <times/>
                <ci> cA </ci>
                <ci> cC </ci>
                <ci> cD </ci>
              </apply>
              <apply>
                <divide/>
                <cn> 1 </cn>
                <cn> 2 </cn>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
    <functionDefinition id="function_24" metaid="metaid_0000026" name="function_4_Transition camT_ca3_BCD to camR_ca3_BCD">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> kTR </ci>
          </bvar>
          <bvar>
            <ci> cB </ci>
          </bvar>
          <bvar>
            <ci> cC </ci>
          </bvar>
          <bvar>
            <ci> cD </ci>
          </bvar>
          <bvar>
            <ci> species_v_31 </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> species_v_31 </ci>
              <ci> kTR </ci>
            </apply>
            <apply>
              <power/>
              <apply>
                <times/>
                <ci> cB </ci>
                <ci> cC </ci>
                <ci> cD </ci>
              </apply>
              <apply>
                <divide/>
                <cn> 1 </cn>
                <cn> 2 </cn>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
    <functionDefinition id="function_25" metaid="metaid_0000027" name="function_4_Transition camR_ca4_ABCD to camT_ca4_ABCD">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> cA </ci>
          </bvar>
          <bvar>
            <ci> cB </ci>
          </bvar>
          <bvar>
            <ci> cC </ci>
          </bvar>
          <bvar>
            <ci> cD </ci>
          </bvar>
          <bvar>
            <ci> kRT </ci>
          </bvar>
          <bvar>
            <ci> species_v_16 </ci>
          </bvar>
          <apply>
            <times/>
            <ci> species_v_16 </ci>
            <ci> kRT </ci>
            <apply>
              <power/>
              <apply>
                <times/>
                <ci> cA </ci>
                <ci> cB </ci>
                <ci> cC </ci>
                <ci> cD </ci>
              </apply>
              <apply>
                <divide/>
                <cn> 1 </cn>
                <cn> 2 </cn>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
    <functionDefinition id="function_26" metaid="metaid_0000028" name="function_4_Transition camT_ca4_ABCD to camR_ca4_ABCD">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <lambda>
          <bvar>
            <ci> kTR </ci>
          </bvar>
          <bvar>
            <ci> cA </ci>
          </bvar>
          <bvar>
            <ci> cB </ci>
          </bvar>
          <bvar>
            <ci> cC </ci>
          </bvar>
          <bvar>
            <ci> cD </ci>
          </bvar>
          <bvar>
            <ci> species_v_32 </ci>
          </bvar>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> species_v_32 </ci>
              <ci> kTR </ci>
            </apply>
            <apply>
              <power/>
              <apply>
                <times/>
                <ci> cA </ci>
                <ci> cB </ci>
                <ci> cC </ci>
                <ci> cD </ci>
              </apply>
              <apply>
                <divide/>
                <cn> 1 </cn>
                <cn> 2 </cn>
              </apply>
            </apply>
          </apply>
        </lambda>
      </math>
    </functionDefinition>
  </listOfFunctionDefinitions>
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        <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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                <rdf:li rdf:resource="urn:miriam:kegg.compound:C00391"/>
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                <rdf:li rdf:resource="urn:miriam:uniprot:P62158"/>
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        <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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        <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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        <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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                <rdf:li rdf:resource="urn:miriam:obo.chebi:CHEBI%3A29108"/>
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        <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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    <species compartment="Spine" id="camR_ca2_CD_PP2B" initialConcentration="0" metaid="metaid_0000152" name="camR_ca2_CD_PP2B"/>
    <species compartment="Spine" id="camR_ca3_ABC_PP2B" initialConcentration="0" metaid="metaid_0000153" name="camR_ca3_ABC_PP2B"/>
    <species compartment="Spine" id="camR_ca3_ABD_PP2B" initialConcentration="0" metaid="metaid_0000154" name="camR_ca3_ABD_PP2B"/>
    <species compartment="Spine" id="camR_ca3_ACD_PP2B" initialConcentration="0" metaid="metaid_0000155" name="camR_ca3_ACD_PP2B"/>
    <species compartment="Spine" id="camR_ca3_BCD_PP2B" initialConcentration="0" metaid="metaid_0000156" name="camR_ca3_BCD_PP2B"/>
    <species compartment="Spine" id="camR_ca4_ABCD_PP2B" initialConcentration="0" metaid="metaid_0000157" name="camR_ca4_ABCD_PP2B"/>
  </listOfSpecies>
  <listOfParameters>
    <parameter id="kon" metaid="metaid_0000029" name="kon" value="1000000"/>
    <parameter constant="false" id="koffRA" metaid="metaid_0000030" name="koffRA" value="8.32"/>
    <parameter constant="false" id="koffRB" metaid="metaid_0000031" name="koffRB" value="0.0166"/>
    <parameter constant="false" id="koffRC" metaid="metaid_0000032" name="koffRC" value="17.4"/>
    <parameter constant="false" id="koffRD" metaid="metaid_0000033" name="koffRD" value="0.0145"/>
    <parameter constant="false" id="koffTA" metaid="metaid_0000034" name="koffTA" value="2101.0101010101"/>
    <parameter constant="false" id="koffTB" metaid="metaid_0000035" name="koffTB" value="4.19191919191919"/>
    <parameter constant="false" id="koffTC" metaid="metaid_0000036" name="koffTC" value="4393.93939393939"/>
    <parameter constant="false" id="koffTD" metaid="metaid_0000037" name="koffTD" value="3.66161616161616"/>
    <parameter id="kRT" metaid="metaid_0000038" name="kRT" value="1000000"/>
    <parameter constant="false" id="kTR" metaid="metaid_0000039" name="kTR" value="48.3792936623125"/>
    <parameter id="cA" metaid="metaid_0000040" name="cA" value="0.00396"/>
    <parameter id="cB" metaid="metaid_0000041" name="cB" value="0.00396"/>
    <parameter id="cC" metaid="metaid_0000042" name="cC" value="0.00396"/>
    <parameter id="cD" metaid="metaid_0000043" name="cD" value="0.00396"/>
    <parameter id="konCaMKII" metaid="metaid_0000044" name="konCaMKII" value="3200000"/>
    <parameter id="koffCaMKII" metaid="metaid_0000045" name="koffCaMKII" value="0.343"/>
    <parameter id="konPP2B" metaid="metaid_0000046" name="konPP2B" value="46000000"/>
    <parameter id="koffPP2B" metaid="metaid_0000047" name="koffPP2B" value="0.4"/>
    <parameter constant="false" id="free_camR_ca3_total" metaid="metaid_0000048" name="free_camR_ca3_total" value="0"/>
    <parameter constant="false" id="free_camT_ca3_total" metaid="metaid_0000049" name="free_camT_ca3_total" value="0"/>
    <parameter constant="false" id="free_cam_ca3_total" metaid="metaid_0000050" name="free_cam_ca3_total" value="0"/>
    <parameter constant="false" id="cam_ca4_total" metaid="metaid_0000051" name="cam_ca4_total" value="0"/>
    <parameter constant="false" id="CaMKII_camR_ca1" metaid="metaid_0000052" name="CaMKII_camR_ca1" value="0"/>
    <parameter constant="false" id="CaMKII_camR_ca2" metaid="metaid_0000053" name="CaMKII_camR_ca2" value="0"/>
    <parameter constant="false" id="CaMKII_camR_ca3" metaid="metaid_0000054" name="CaMKII_camR_ca3" value="0"/>
    <parameter constant="false" id="total_CaMKII_bound" metaid="metaid_0000055" name="total_CaMKII_bound" value="0"/>
    <parameter constant="false" id="total_CaMKII" metaid="metaid_0000056" name="total CaMKII" value="7e-05"/>
    <parameter constant="false" id="CaMKIIbar" metaid="metaid_0000057" name="CaMKIIbar" value="0"/>
    <parameter constant="false" id="PP2B_camR_ca1" metaid="metaid_0000058" name="PP2B_camR_ca1" value="0"/>
    <parameter constant="false" id="PP2B_camR_ca2" metaid="metaid_0000059" name="PP2B_camR_ca2" value="0"/>
    <parameter constant="false" id="PP2B_camR_ca3" metaid="metaid_0000060" name="PP2B_camR_ca3" value="0"/>
    <parameter constant="false" id="total_PP2B_bound" metaid="metaid_0000061" name="total_PP2B_bound" value="0"/>
    <parameter constant="false" id="total_PP2B" metaid="metaid_0000062" name="total PP2B" value="1.6e-06"/>
    <parameter constant="false" id="PP2Bbar" metaid="metaid_0000063" name="PP2Bbar" value="0"/>
    <parameter constant="false" id="camR_unbound" metaid="metaid_0000064" name="camR_unbound" value="9.7e-12"/>
    <parameter constant="false" id="total_camR" metaid="metaid_0000065" name="total camR" value="9.7e-12"/>
    <parameter constant="false" id="total_camT" metaid="metaid_0000066" name="total camT" value="2e-07"/>
    <parameter constant="false" id="Rbar" metaid="metaid_0000067" name="Rbar" value="4.84976478640786e-05"/>
    <parameter constant="false" id="cam_ca3_total" metaid="metaid_0000068" name="cam_ca3_total" value="0"/>
    <parameter constant="false" id="free_camR_ca2_total" metaid="metaid_0000069" name="free_camR_ca2_total" value="0"/>
    <parameter constant="false" id="free_camT_ca2_total" metaid="metaid_0000070" name="free_camT_ca2_total" value="0"/>
    <parameter constant="false" id="free_cam_ca2_total" metaid="metaid_0000071" name="free_cam_ca2_total" value="0"/>
    <parameter constant="false" id="cam_ca2_total" metaid="metaid_0000072" name="cam_ca2_total" value="0"/>
    <parameter constant="false" id="free_cam_ca1_total" metaid="metaid_0000073" name="free_cam_ca1_total" value="0"/>
    <parameter constant="false" id="cam_ca1_total" metaid="metaid_0000074" name="cam_ca1_total" value="0"/>
    <parameter constant="false" id="cam_ca0_total" metaid="metaid_0000075" name="cam_ca0_total" value="2.000097e-07"/>
    <parameter constant="false" id="cam_total" metaid="metaid_0000076" name="cam_total" value="2.000097e-07"/>
    <parameter constant="false" id="moles_bound_ca_per_moles_cam" metaid="metaid_0000077" name="moles_bound_ca_per_moles_cam" value="0"/>
    <parameter id="L" metaid="metaid_0000078" name="L" value="20670"/>
    <parameter id="KRA" metaid="metaid_0000079" name="KRA" value="8.32e-06"/>
    <parameter id="KRB" metaid="metaid_0000080" name="KRB" value="1.66e-08"/>
    <parameter id="KRC" metaid="metaid_0000081" name="KRC" value="1.74e-05"/>
    <parameter id="KRD" metaid="metaid_0000082" name="KRD" value="1.45e-08"/>
    
    
    
    
    <parameter constant="false" id="epsilon" metaid="metaid_0000087" name="epsilon" value="4.84976478640786e-05"/>
    <parameter constant="false" id="ybar" metaid="metaid_0000088" name="ybar" value="0"/>
    <parameter constant="false" id="ybar1ybar" metaid="metaid_0000089" name="ybar/(1-ybar)" value="0"/>
  </listOfParameters>
  <listOfRules>
    <assignmentRule metaid="metaid_0000158" variable="koffRA">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <times/>
          <ci> KRA </ci>
          <ci> kon </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000159" variable="free_camT_ca3_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camT_ca3_ABC </ci>
          <ci> camT_ca3_ABD </ci>
          <ci> camT_ca3_ACD </ci>
          <ci> camT_ca3_BCD </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000160" variable="koffRB">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <times/>
          <ci> KRB </ci>
          <ci> kon </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000161" variable="koffRC">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <times/>
          <ci> KRC </ci>
          <ci> kon </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000162" variable="koffRD">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <times/>
          <ci> KRD </ci>
          <ci> kon </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000163" variable="koffTA">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> koffRA </ci>
          <ci> cA </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000164" variable="koffTB">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> koffRB </ci>
          <ci> cB </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000165" variable="koffTC">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> koffRC </ci>
          <ci> cC </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000166" variable="koffTD">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> koffRD </ci>
          <ci> cD </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000167" variable="kTR">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> kRT </ci>
          <ci> L </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000168" variable="free_camR_ca3_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca3_ABC </ci>
          <ci> camR_ca3_ABD </ci>
          <ci> camR_ca3_ACD </ci>
          <ci> camR_ca3_BCD </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000169" variable="free_cam_ca3_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> free_camR_ca3_total </ci>
          <ci> free_camT_ca3_total </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000170" variable="cam_ca4_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca4_ABCD </ci>
          <ci> camT_ca4_ABCD </ci>
          <ci> camR_ca4_ABCD_CaMKII </ci>
          <ci> camR_ca4_ABCD_PP2B </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000171" variable="CaMKII_camR_ca1">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca1_A_CaMKII </ci>
          <ci> camR_ca1_B_CaMKII </ci>
          <ci> camR_ca1_C_CaMKII </ci>
          <ci> camR_ca1_D_CaMKII </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000172" variable="CaMKII_camR_ca3">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca3_ABC_CaMKII </ci>
          <ci> camR_ca3_ABD_CaMKII </ci>
          <ci> camR_ca3_ACD_CaMKII </ci>
          <ci> camR_ca3_BCD_CaMKII </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000173" variable="CaMKII_camR_ca2">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca2_AB_CaMKII </ci>
          <ci> camR_ca2_AC_CaMKII </ci>
          <ci> camR_ca2_AD_CaMKII </ci>
          <ci> camR_ca2_BC_CaMKII </ci>
          <ci> camR_ca2_BD_CaMKII </ci>
          <ci> camR_ca2_CD_CaMKII </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000174" variable="total_CaMKII_bound">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_CaMKII </ci>
          <ci> CaMKII_camR_ca1 </ci>
          <ci> CaMKII_camR_ca2 </ci>
          <ci> CaMKII_camR_ca3 </ci>
          <ci> camR_ca4_ABCD_CaMKII </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000175" variable="total_CaMKII">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> total_CaMKII_bound </ci>
          <ci> CaMKII </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000176" variable="CaMKIIbar">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> total_CaMKII_bound </ci>
          <ci> total_CaMKII </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000177" variable="PP2B_camR_ca1">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca1_A_PP2B </ci>
          <ci> camR_ca1_B_PP2B </ci>
          <ci> camR_ca1_C_PP2B </ci>
          <ci> camR_ca1_D_PP2B </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000178" variable="PP2B_camR_ca2">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca2_AB_PP2B </ci>
          <ci> camR_ca2_AC_PP2B </ci>
          <ci> camR_ca2_AD_PP2B </ci>
          <ci> camR_ca2_BC_PP2B </ci>
          <ci> camR_ca2_BD_PP2B </ci>
          <ci> camR_ca2_CD_PP2B </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000179" variable="PP2B_camR_ca3">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca3_ABC_PP2B </ci>
          <ci> camR_ca3_ABD_PP2B </ci>
          <ci> camR_ca3_ACD_PP2B </ci>
          <ci> camR_ca3_BCD_PP2B </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000180" variable="total_PP2B_bound">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_PP2B </ci>
          <ci> PP2B_camR_ca1 </ci>
          <ci> PP2B_camR_ca2 </ci>
          <ci> PP2B_camR_ca3 </ci>
          <ci> camR_ca4_ABCD_PP2B </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000181" variable="camR_unbound">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR </ci>
          <ci> camR_ca1_A </ci>
          <ci> camR_ca1_B </ci>
          <ci> camR_ca1_C </ci>
          <ci> camR_ca1_D </ci>
          <ci> camR_ca2_AB </ci>
          <ci> camR_ca2_AC </ci>
          <ci> camR_ca2_AD </ci>
          <ci> camR_ca2_BC </ci>
          <ci> camR_ca2_BD </ci>
          <ci> camR_ca2_CD </ci>
          <ci> camR_ca3_ABC </ci>
          <ci> camR_ca3_ABD </ci>
          <ci> camR_ca3_ACD </ci>
          <ci> camR_ca3_BCD </ci>
          <ci> camR_ca4_ABCD </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000182" variable="total_PP2B">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> total_PP2B_bound </ci>
          <ci> PP2B </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000183" variable="PP2Bbar">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> total_PP2B_bound </ci>
          <ci> total_PP2B </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000184" variable="total_camT">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camT </ci>
          <ci> camT_ca1_A </ci>
          <ci> camT_ca1_B </ci>
          <ci> camT_ca1_C </ci>
          <ci> camT_ca1_D </ci>
          <ci> camT_ca2_AB </ci>
          <ci> camT_ca2_AC </ci>
          <ci> camT_ca2_AD </ci>
          <ci> camT_ca2_BC </ci>
          <ci> camT_ca2_BD </ci>
          <ci> camT_ca2_CD </ci>
          <ci> camT_ca3_ABC </ci>
          <ci> camT_ca3_ABD </ci>
          <ci> camT_ca3_ACD </ci>
          <ci> camT_ca3_BCD </ci>
          <ci> camT_ca4_ABCD </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000185" variable="total_camR">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_unbound </ci>
          <ci> total_CaMKII_bound </ci>
          <ci> total_PP2B_bound </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000186" variable="cam_ca3_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> CaMKII_camR_ca3 </ci>
          <ci> PP2B_camR_ca3 </ci>
          <ci> free_cam_ca3_total </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000187" variable="Rbar">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> total_camR </ci>
          <apply>
            <plus/>
            <ci> total_camR </ci>
            <ci> total_camT </ci>
          </apply>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000188" variable="free_camR_ca2_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca2_AB </ci>
          <ci> camR_ca2_AC </ci>
          <ci> camR_ca2_AD </ci>
          <ci> camR_ca2_BC </ci>
          <ci> camR_ca2_BD </ci>
          <ci> camR_ca2_CD </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000189" variable="free_camT_ca2_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camT_ca2_AB </ci>
          <ci> camT_ca2_AC </ci>
          <ci> camT_ca2_AD </ci>
          <ci> camT_ca2_BC </ci>
          <ci> camT_ca2_BD </ci>
          <ci> camT_ca2_CD </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000190" variable="free_cam_ca2_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> free_camR_ca2_total </ci>
          <ci> free_camT_ca2_total </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000191" variable="cam_ca2_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> free_cam_ca2_total </ci>
          <ci> CaMKII_camR_ca2 </ci>
          <ci> PP2B_camR_ca2 </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000192" variable="free_cam_ca1_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR_ca1_A </ci>
          <ci> camR_ca1_B </ci>
          <ci> camR_ca1_C </ci>
          <ci> camR_ca1_D </ci>
          <ci> camT_ca1_A </ci>
          <ci> camT_ca1_B </ci>
          <ci> camT_ca1_C </ci>
          <ci> camT_ca1_D </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000193" variable="cam_ca1_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> free_cam_ca1_total </ci>
          <ci> CaMKII_camR_ca1 </ci>
          <ci> PP2B_camR_ca1 </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000194" variable="cam_ca0_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> camR </ci>
          <ci> camT </ci>
          <ci> camR_CaMKII </ci>
          <ci> camR_PP2B </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000195" variable="cam_total">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <plus/>
          <ci> cam_ca0_total </ci>
          <ci> cam_ca1_total </ci>
          <ci> cam_ca2_total </ci>
          <ci> cam_ca3_total </ci>
          <ci> cam_ca4_total </ci>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000196" variable="moles_bound_ca_per_moles_cam">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <apply>
            <plus/>
            <apply>
              <times/>
              <cn> 4 </cn>
              <ci> cam_ca4_total </ci>
            </apply>
            <apply>
              <times/>
              <cn> 3 </cn>
              <ci> cam_ca3_total </ci>
            </apply>
            <apply>
              <times/>
              <cn> 2 </cn>
              <ci> cam_ca2_total </ci>
            </apply>
            <ci> cam_ca1_total </ci>
          </apply>
          <ci> cam_total </ci>
        </apply>
      </math>
    </assignmentRule>
    
    
    
    
    <assignmentRule metaid="metaid_0000201" variable="epsilon">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> camR </ci>
          <apply>
            <plus/>
            <ci> camR </ci>
            <ci> camT </ci>
          </apply>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000202" variable="ybar">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> moles_bound_ca_per_moles_cam </ci>
          <cn> 4 </cn>
        </apply>
      </math>
    </assignmentRule>
    <assignmentRule metaid="metaid_0000203" variable="ybar1ybar">
      <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
          <divide/>
          <ci> ybar </ci>
          <apply>
            <minus/>
            <cn> 1 </cn>
            <ci> ybar </ci>
          </apply>
        </apply>
      </math>
    </assignmentRule>
  </listOfRules>
  <listOfReactions>
    <reaction id="reaction_0" metaid="metaid_0000204" name="Ca binding to camR site A" reversible="false" sboTerm="SBO:0000177">
      <annotation>
        <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
          <rdf:Description rdf:about="#metaid_0000204">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005509"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="camR"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_A"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_1" metaid="metaid_0000205" name="Ca binding to camR site B" reversible="false" sboTerm="SBO:0000177">
      <annotation>
        <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
          <rdf:Description rdf:about="#metaid_0000205">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005509"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="camR"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_2" metaid="metaid_0000206" name="Ca binding to camR site C" reversible="false" sboTerm="SBO:0000177">
      <annotation>
        <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
          <rdf:Description rdf:about="#metaid_0000206">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005509"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="camR"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_3" metaid="metaid_0000207" name="Ca binding to camR site D" reversible="false" sboTerm="SBO:0000177">
      <annotation>
        <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
          <rdf:Description rdf:about="#metaid_0000207">
            <bqbiol:isVersionOf>
              <rdf:Bag>
                <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005509"/>
              </rdf:Bag>
            </bqbiol:isVersionOf>
          </rdf:Description>
        </rdf:RDF>
      </annotation>
      <listOfReactants>
        <speciesReference species="camR"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_4" metaid="metaid_0000208" name="Ca dissociating from camR_ca1_A site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_A"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca1_A </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_5" metaid="metaid_0000209" name="Ca dissociating from camR_ca1_B site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca1_B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_6" metaid="metaid_0000210" name="Ca dissociating from camR_ca1_C site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_C"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca1_C </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_7" metaid="metaid_0000211" name="Ca dissociating from camR_ca1_D site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_D"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca1_D </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_8" metaid="metaid_0000212" name="Ca binding to camR_ca1_A site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_A </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_9" metaid="metaid_0000213" name="Ca binding to camR_ca1_A site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_A </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_10" metaid="metaid_0000214" name="Ca binding to camR_ca1_A site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_A </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_11" metaid="metaid_0000215" name="Ca binding to camR_ca1_B site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_12" metaid="metaid_0000216" name="Ca binding to camR_ca1_B site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_13" metaid="metaid_0000217" name="Ca binding to camR_ca1_B site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_14" metaid="metaid_0000218" name="Ca binding to camR_ca1_C site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_C </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_15" metaid="metaid_0000219" name="Ca binding to camR_ca1_C site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_C </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_16" metaid="metaid_0000220" name="Ca binding to camR_ca1_C site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_C </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_17" metaid="metaid_0000221" name="Ca binding to camR_ca1_D site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_D </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_18" metaid="metaid_0000222" name="Ca binding to camR_ca1_D site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_D </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_19" metaid="metaid_0000223" name="Ca binding to camR_ca1_D site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_D </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_20" metaid="metaid_0000224" name="Ca dissociating from camR_ca2_AB site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca2_AB </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_21" metaid="metaid_0000225" name="Ca dissociating from camR_ca2_AC site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca2_AC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_22" metaid="metaid_0000226" name="Ca dissociating from camR_ca2_AD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca2_AD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_23" metaid="metaid_0000227" name="Ca dissociating from camR_ca2_AB site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca2_AB </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_24" metaid="metaid_0000228" name="Ca dissociating from camR_ca2_BC site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca2_BC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_25" metaid="metaid_0000229" name="Ca dissociating from camR_ca2_BD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca2_BD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_26" metaid="metaid_0000230" name="Ca dissociating from camR_ca2_AC site A " reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca2_AC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_27" metaid="metaid_0000231" name="Ca dissociating from camR_ca2_BC site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca2_BC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_28" metaid="metaid_0000232" name="Ca dissociating from camR_ca2_CD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca2_CD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_29" metaid="metaid_0000233" name="Ca dissociating from camR_ca2_AD site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca2_AD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_30" metaid="metaid_0000234" name="Ca dissociating from camR_ca2_BD site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca2_BD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_31" metaid="metaid_0000235" name="Ca dissociating from camR_ca2_CD site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca2_CD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_32" metaid="metaid_0000236" name="Ca binding to camR_ca2_AB site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AB </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_33" metaid="metaid_0000237" name="Ca binding to camR_ca2_AB site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AB </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_34" metaid="metaid_0000238" name="Ca binding to camR_ca2_AC site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_35" metaid="metaid_0000239" name="Ca binding to camR_ca2_AC site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_36" metaid="metaid_0000240" name="Ca binding to camR_ca2_AD site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_37" metaid="metaid_0000241" name="Ca binding to camR_ca2_AD site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_38" metaid="metaid_0000242" name="Ca binding to camR_ca2_BC site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_BC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_39" metaid="metaid_0000243" name="Ca binding to camR_ca2_BC site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_BC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_40" metaid="metaid_0000244" name="Ca binding to camR_ca2_BD site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_BD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_41" metaid="metaid_0000245" name="Ca binding to camR_ca2_BD site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_BD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_42" metaid="metaid_0000246" name="Ca binding to camR_ca2_CD site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_CD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_43" metaid="metaid_0000247" name="Ca binding to camR_ca2_CD site B " reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_CD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_44" metaid="metaid_0000248" name="Ca dissociating from camR_ca3_ABC site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca3_ABC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_45" metaid="metaid_0000249" name="Ca dissociating from camR_ca3_ABC site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca3_ABC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_46" metaid="metaid_0000250" name="Ca dissociating from camR_ca3_ABC site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca3_ABC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_47" metaid="metaid_0000251" name="Ca dissociating from camR_ca3_ABD site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca3_ABD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_48" metaid="metaid_0000252" name="Ca dissociating from camR_ca3_ABD site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca3_ABD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_49" metaid="metaid_0000253" name="Ca dissociating from camR_ca3_ABD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca3_ABD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_50" metaid="metaid_0000254" name="Ca dissociating from camR_ca3_ACD site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca3_ACD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_51" metaid="metaid_0000255" name="Ca dissociating from camR_ca3_ACD site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca3_ACD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_52" metaid="metaid_0000256" name="Ca dissociating from camR_ca3_ACD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca3_ACD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_53" metaid="metaid_0000257" name="Ca dissociating from camR_ca3_BCD site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca3_BCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_54" metaid="metaid_0000258" name="Ca dissociating from camR_ca3_BCD site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca3_BCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_55" metaid="metaid_0000259" name="Ca dissociating from camR_ca3_BCD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca3_BCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_56" metaid="metaid_0000260" name="Ca binding to camR_ca3_ABC site D " reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca3_ABC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_57" metaid="metaid_0000261" name="Ca binding to camR_ca3_ABD site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca3_ABD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_58" metaid="metaid_0000262" name="Ca binding to camR_ca3_ACD site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca3_ACD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_59" metaid="metaid_0000263" name="Ca binding to camR_ca3_BCD site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca3_BCD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_60" metaid="metaid_0000264" name="Ca dissociating from camR_ca4_ABCD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca4_ABCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_61" metaid="metaid_0000265" name="Ca dissociating from camR_ca4_ABCD site C " reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca4_ABCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_62" metaid="metaid_0000266" name="Ca dissociating from camR_ca4_ABCD site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca4_ABCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_63" metaid="metaid_0000267" name="Ca dissociating from camR_ca4_ABCD site A " reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca4_ABCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_64" metaid="metaid_0000268" name="Ca binding to camT site A " reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_A"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_65" metaid="metaid_0000269" name="Ca binding to camT site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_66" metaid="metaid_0000270" name="Ca binding to camT site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_C"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_67" metaid="metaid_0000271" name="Ca binding to camT site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_D"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_68" metaid="metaid_0000272" name="Ca dissociating from camT_ca1_A site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca1_A"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTA </ci>
            <ci> camT_ca1_A </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_69" metaid="metaid_0000273" name="Ca dissociating from camT_ca1_B site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca1_B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTB </ci>
            <ci> camT_ca1_B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_70" metaid="metaid_0000274" name="Ca dissociating from camT_ca1_C site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca1_C"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTC </ci>
            <ci> camT_ca1_C </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_71" metaid="metaid_0000275" name="Ca dissociating from camT_ca1_D site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca1_D"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTD </ci>
            <ci> camT_ca1_D </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_72" metaid="metaid_0000276" name="Ca binding to camT_ca1_A site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AB"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_A </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_73" metaid="metaid_0000277" name="Ca binding to camT_ca1_A site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_A </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_74" metaid="metaid_0000278" name="Ca binding to camT_ca1_A site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_A </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_75" metaid="metaid_0000279" name="Ca binding to camT_ca1_B site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AB"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_76" metaid="metaid_0000280" name="Ca binding to camT_ca1_B site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_BC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_77" metaid="metaid_0000281" name="Ca binding to camT_ca1_B site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_BD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_78" metaid="metaid_0000282" name="Ca binding to camT_ca1_C site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_C </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_79" metaid="metaid_0000283" name="Ca binding to camT_ca1_C site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_BC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_C </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_80" metaid="metaid_0000284" name="Ca binding to camT_ca1_C site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_CD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_C </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_81" metaid="metaid_0000285" name="Ca binding to camT_ca1_D site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_D </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_82" metaid="metaid_0000286" name="Ca binding to camT_ca1_D site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_BD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_D </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_83" metaid="metaid_0000287" name="Ca binding to camT_ca1_D site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_CD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca1_D </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_84" metaid="metaid_0000288" name="Ca dissociating from camT_ca2_AB site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_AB"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTA </ci>
            <ci> camT_ca2_AB </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_85" metaid="metaid_0000289" name="Ca dissociating from camT_ca2_AB site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_AB"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTB </ci>
            <ci> camT_ca2_AB </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_86" metaid="metaid_0000290" name="Ca dissociating from camT_ca2_AC site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_AC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTA </ci>
            <ci> camT_ca2_AC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_87" metaid="metaid_0000291" name="Ca dissociating from camT_ca2_AC site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_AC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTC </ci>
            <ci> camT_ca2_AC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_88" metaid="metaid_0000292" name="Ca dissociating from camT_ca2_AD site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_AD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTA </ci>
            <ci> camT_ca2_AD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_89" metaid="metaid_0000293" name="Ca dissociating from camT_ca2_AD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_AD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_A"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTD </ci>
            <ci> camT_ca2_AD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_90" metaid="metaid_0000294" name="Ca dissociating from camT_ca2_BC site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_BC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTB </ci>
            <ci> camT_ca2_BC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_91" metaid="metaid_0000295" name="Ca dissociating from camT_ca2_BC site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_BC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTC </ci>
            <ci> camT_ca2_BC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_92" metaid="metaid_0000296" name="Ca dissociating from camT_ca2_BD site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_BD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTB </ci>
            <ci> camT_ca2_BD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_93" metaid="metaid_0000297" name="Ca dissociating from camT_ca2_BD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_BD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTD </ci>
            <ci> camT_ca2_BD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_94" metaid="metaid_0000298" name="Ca dissociating from camT_ca2_CD site C " reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_CD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_D"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTC </ci>
            <ci> camT_ca2_CD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_95" metaid="metaid_0000299" name="Ca dissociating from camT_ca2_CD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_CD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_C"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTD </ci>
            <ci> camT_ca2_CD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_96" metaid="metaid_0000300" name="Ca binding to camT_ca2_AB site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_AB"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ABC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_AB </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_97" metaid="metaid_0000301" name="Ca binding to camT_ca2_AB site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_AB"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ABD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_AB </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_98" metaid="metaid_0000302" name="Ca binding to camT_ca2_AC site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_AC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ABC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_AC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_99" metaid="metaid_0000303" name="Ca binding to camT_ca2_AC site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_AC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ACD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_AC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_100" metaid="metaid_0000304" name="Ca binding to camT_ca2_AD site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_AD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ABD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_AD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_101" metaid="metaid_0000305" name="Ca binding to camT_ca2_AD site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_AD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ACD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_AD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_102" metaid="metaid_0000306" name="Ca binding to camT_ca2_BC site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_BC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ABC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_BC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_103" metaid="metaid_0000307" name="Ca binding to camT_ca2_BC site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_BC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_BCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_BC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_104" metaid="metaid_0000308" name="Ca binding to camT_ca2_BD site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_BD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ABD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_BD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_105" metaid="metaid_0000309" name="Ca binding to camT_ca2_BD site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_BD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_BCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_BD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_106" metaid="metaid_0000310" name="Ca binding to camT_ca2_CD site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca2_CD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ACD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_CD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_107" metaid="metaid_0000311" name="Ca binding to camT_ca2_CD site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca2_CD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_BCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca2_CD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_108" metaid="metaid_0000312" name="Ca dissociating from camT_ca3_ABC site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTB </ci>
            <ci> camT_ca3_ABC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_109" metaid="metaid_0000313" name="Ca dissociating from camT_ca3_ABC site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_BC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTA </ci>
            <ci> camT_ca3_ABC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_110" metaid="metaid_0000314" name="Ca dissociating from camT_ca3_ABD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AB"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTD </ci>
            <ci> camT_ca3_ABD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_111" metaid="metaid_0000315" name="Ca dissociating from camT_ca3_ABD site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTB </ci>
            <ci> camT_ca3_ABD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_112" metaid="metaid_0000316" name="Ca dissociating from camT_ca3_ABD site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_BD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTA </ci>
            <ci> camT_ca3_ABD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_113" metaid="metaid_0000317" name="Ca dissociating from camT_ca3_ACD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_ACD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTD </ci>
            <ci> camT_ca3_ACD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_114" metaid="metaid_0000318" name="Ca dissociating from camT_ca3_ACD site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_ACD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTC </ci>
            <ci> camT_ca3_ACD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_115" metaid="metaid_0000319" name="Ca dissociating from camT_ca3_ACD site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_ACD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_CD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTA </ci>
            <ci> camT_ca3_ACD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_116" metaid="metaid_0000320" name="Ca dissociating from camT_ca3_BCD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_BCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_BC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTD </ci>
            <ci> camT_ca3_BCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_117" metaid="metaid_0000321" name="Ca dissociating from camT_ca3_BCD site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_BCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_BD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTC </ci>
            <ci> camT_ca3_BCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_118" metaid="metaid_0000322" name="Ca dissociating from camT_ca3_BCD site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_BCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_CD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTB </ci>
            <ci> camT_ca3_BCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_119" metaid="metaid_0000323" name="Ca binding to camT_ca3_ABC site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABC"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca4_ABCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca3_ABC </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_120" metaid="metaid_0000324" name="Ca binding to camT_ca3_ABD site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca4_ABCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca3_ABD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_121" metaid="metaid_0000325" name="Ca binding to camT_ca3_ACD site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca3_ACD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca4_ABCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca3_ACD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_122" metaid="metaid_0000326" name="Ca binding to camT_ca3_BCD site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca3_BCD"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca4_ABCD"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camT_ca3_BCD </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_123" metaid="metaid_0000327" name="Ca dissociating from camT_ca4_ABCD site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca4_ABCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ABC"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTD </ci>
            <ci> camT_ca4_ABCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_124" metaid="metaid_0000328" name="Ca dissociating from camT_ca4_ABCD site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca4_ABCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ABD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTC </ci>
            <ci> camT_ca4_ABCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_125" metaid="metaid_0000329" name="Ca dissociating from camT_ca4_ABCD site B " reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca4_ABCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_ACD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTB </ci>
            <ci> camT_ca4_ABCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_126" metaid="metaid_0000330" name="Ca dissociating from camT_ca4_ABCD site A " reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca4_ABCD"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca3_BCD"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTA </ci>
            <ci> camT_ca4_ABCD </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_127" metaid="metaid_0000331" name="Transition camR to camT" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kRT </ci>
            <ci> camR </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_128" metaid="metaid_0000332" name="Transition camT to camR" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kTR </ci>
            <ci> camT </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_129" metaid="metaid_0000333" name="Transition camR_ca1_A to camT_ca1_A" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca1_A"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca1_A"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kRT </ci>
            <ci> camR_ca1_A </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_130" metaid="metaid_0000334" name="Transition camR_ca1_B to camT_ca1_B" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca1_B"/>
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      <listOfProducts>
        <speciesReference species="camT_ca1_B"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kRT </ci>
            <ci> camR_ca1_B </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_131" metaid="metaid_0000335" name="Transition camR_ca1_C to camT_ca1_C" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca1_C"/>
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      <listOfProducts>
        <speciesReference species="camT_ca1_C"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kRT </ci>
            <ci> camR_ca1_C </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_132" metaid="metaid_0000336" name="Transition camR_ca1_D to camT_ca1_D" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca1_D"/>
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      <listOfProducts>
        <speciesReference species="camT_ca1_D"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kRT </ci>
            <ci> camR_ca1_D </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_133" metaid="metaid_0000337" name="Transition camT_ca1_A to camR_ca1_A" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca1_A"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_A"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_1 </ci>
              <ci> kTR </ci>
              <ci> cA </ci>
              <ci> camT_ca1_A </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_134" metaid="metaid_0000338" name="Transition camT_ca1_B to camR_ca1_B" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca1_B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_B"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_2 </ci>
              <ci> kTR </ci>
              <ci> cB </ci>
              <ci> camT_ca1_B </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_135" metaid="metaid_0000339" name="Transition camT_ca1_C to camR_ca1_C" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca1_C"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_C"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_3 </ci>
              <ci> kTR </ci>
              <ci> cC </ci>
              <ci> camT_ca1_C </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_136" metaid="metaid_0000340" name="Transition camT_ca1_D to camR_ca1_D" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca1_D"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_D"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_4 </ci>
              <ci> kTR </ci>
              <ci> cD </ci>
              <ci> camT_ca1_D </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_137" metaid="metaid_0000341" name="Transition camR_ca2_AB to camT_ca2_AB" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB"/>
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      <listOfProducts>
        <speciesReference species="camT_ca2_AB"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_5 </ci>
              <ci> cA </ci>
              <ci> cB </ci>
              <ci> kRT </ci>
              <ci> camR_ca2_AB </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_138" metaid="metaid_0000342" name="Transition camR_ca2_AC to camT_ca2_AC" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC"/>
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      <listOfProducts>
        <speciesReference species="camT_ca2_AC"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_6 </ci>
              <ci> cA </ci>
              <ci> cC </ci>
              <ci> kRT </ci>
              <ci> camR_ca2_AC </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_139" metaid="metaid_0000343" name="Transition camR_ca2_AD to camT_ca2_AD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD"/>
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      <listOfProducts>
        <speciesReference species="camT_ca2_AD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_7 </ci>
              <ci> cA </ci>
              <ci> cD </ci>
              <ci> kRT </ci>
              <ci> camR_ca2_AD </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_140" metaid="metaid_0000344" name="Transition camR_ca2_BC to camT_ca2_BC" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC"/>
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      <listOfProducts>
        <speciesReference species="camT_ca2_BC"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_8 </ci>
              <ci> cB </ci>
              <ci> cC </ci>
              <ci> kRT </ci>
              <ci> camR_ca2_BC </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_141" metaid="metaid_0000345" name="Transition camR_ca2_BD to camT_ca2_BD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD"/>
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      <listOfProducts>
        <speciesReference species="camT_ca2_BD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_9 </ci>
              <ci> cB </ci>
              <ci> cD </ci>
              <ci> kRT </ci>
              <ci> camR_ca2_BD </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_142" metaid="metaid_0000346" name="Transition camR_ca2_CD to camT_ca2_CD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD"/>
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      <listOfProducts>
        <speciesReference species="camT_ca2_CD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_10 </ci>
              <ci> cC </ci>
              <ci> cD </ci>
              <ci> kRT </ci>
              <ci> camR_ca2_CD </ci>
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          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_143" metaid="metaid_0000347" name="Transition camT_ca2_AB to camR_ca2_AB" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca2_AB"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_AB"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_11 </ci>
              <ci> kTR </ci>
              <ci> cA </ci>
              <ci> cB </ci>
              <ci> camT_ca2_AB </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_144" metaid="metaid_0000348" name="Transition camT_ca2_AC to camR_ca2_AC" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca2_AC"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_AC"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_12 </ci>
              <ci> kTR </ci>
              <ci> cA </ci>
              <ci> cC </ci>
              <ci> camT_ca2_AC </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_145" metaid="metaid_0000349" name="Transition camT_ca2_AD to camR_ca2_AD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca2_AD"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_AD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_13 </ci>
              <ci> kTR </ci>
              <ci> cA </ci>
              <ci> cD </ci>
              <ci> camT_ca2_AD </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_146" metaid="metaid_0000350" name="Transition camT_ca2_BC to camR_ca2_BC" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca2_BC"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_BC"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_14 </ci>
              <ci> kTR </ci>
              <ci> cB </ci>
              <ci> cC </ci>
              <ci> camT_ca2_BC </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_147" metaid="metaid_0000351" name="Transition camT_ca2_BD to camR_ca2_BD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca2_BD"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_BD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_15 </ci>
              <ci> kTR </ci>
              <ci> cB </ci>
              <ci> cD </ci>
              <ci> camT_ca2_BD </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_148" metaid="metaid_0000352" name="Transition camT_ca2_CD to camR_ca2_CD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca2_CD"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_CD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_16 </ci>
              <ci> kTR </ci>
              <ci> cC </ci>
              <ci> cD </ci>
              <ci> camT_ca2_CD </ci>
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          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_149" metaid="metaid_0000353" name="Transition camR_ca3_ABC to camT_ca3_ABC" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC"/>
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      <listOfProducts>
        <speciesReference species="camT_ca3_ABC"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_17 </ci>
              <ci> cA </ci>
              <ci> cB </ci>
              <ci> cC </ci>
              <ci> kRT </ci>
              <ci> camR_ca3_ABC </ci>
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          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_150" metaid="metaid_0000354" name="Transition camR_ca3_ABD to camT_ca3_ABD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD"/>
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      <listOfProducts>
        <speciesReference species="camT_ca3_ABD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_18 </ci>
              <ci> cA </ci>
              <ci> cB </ci>
              <ci> cD </ci>
              <ci> kRT </ci>
              <ci> camR_ca3_ABD </ci>
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          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_151" metaid="metaid_0000355" name="Transition camR_ca3_ACD to camT_ca3_ACD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD"/>
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      <listOfProducts>
        <speciesReference species="camT_ca3_ACD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_19 </ci>
              <ci> cA </ci>
              <ci> cC </ci>
              <ci> cD </ci>
              <ci> kRT </ci>
              <ci> camR_ca3_ACD </ci>
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          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_152" metaid="metaid_0000356" name="Transition camR_ca3_BCD to camT_ca3_BCD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD"/>
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      <listOfProducts>
        <speciesReference species="camT_ca3_BCD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_20 </ci>
              <ci> cB </ci>
              <ci> cC </ci>
              <ci> cD </ci>
              <ci> kRT </ci>
              <ci> camR_ca3_BCD </ci>
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          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_153" metaid="metaid_0000357" name="Transition camT_ca3_ABC to camR_ca3_ABC" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABC"/>
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      <listOfProducts>
        <speciesReference species="camR_ca3_ABC"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_21 </ci>
              <ci> kTR </ci>
              <ci> cA </ci>
              <ci> cB </ci>
              <ci> cC </ci>
              <ci> camT_ca3_ABC </ci>
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          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_154" metaid="metaid_0000358" name="Transition camT_ca3_ABD to camR_ca3_ABD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABD"/>
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      <listOfProducts>
        <speciesReference species="camR_ca3_ABD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_22 </ci>
              <ci> kTR </ci>
              <ci> cA </ci>
              <ci> cB </ci>
              <ci> cD </ci>
              <ci> camT_ca3_ABD </ci>
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          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_155" metaid="metaid_0000359" name="Transition camT_ca3_ACD to camR_ca3_ACD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca3_ACD"/>
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      <listOfProducts>
        <speciesReference species="camR_ca3_ACD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_23 </ci>
              <ci> kTR </ci>
              <ci> cA </ci>
              <ci> cC </ci>
              <ci> cD </ci>
              <ci> camT_ca3_ACD </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_156" metaid="metaid_0000360" name="Transition camT_ca3_BCD to camR_ca3_BCD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camT_ca3_BCD"/>
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      <listOfProducts>
        <speciesReference species="camR_ca3_BCD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_24 </ci>
              <ci> kTR </ci>
              <ci> cB </ci>
              <ci> cC </ci>
              <ci> cD </ci>
              <ci> camT_ca3_BCD </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_157" metaid="metaid_0000361" name="Transition camR_ca4_ABCD to camT_ca4_ABCD" reversible="false" sboTerm="SBO:0000181">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD"/>
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      <listOfProducts>
        <speciesReference species="camT_ca4_ABCD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_25 </ci>
              <ci> cA </ci>
              <ci> cB </ci>
              <ci> cC </ci>
              <ci> cD </ci>
              <ci> kRT </ci>
              <ci> camR_ca4_ABCD </ci>
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          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_158" metaid="metaid_0000362" name="Transition camT_ca4_ABCD to camR_ca4_ABCD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camT_ca4_ABCD"/>
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      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <apply>
              <ci> function_26 </ci>
              <ci> kTR </ci>
              <ci> cA </ci>
              <ci> cB </ci>
              <ci> cC </ci>
              <ci> cD </ci>
              <ci> camT_ca4_ABCD </ci>
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          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_159" metaid="metaid_0000363" name="CaMKII binding to camR" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR"/>
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      <listOfProducts>
        <speciesReference species="camR_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_160" metaid="metaid_0000364" name="CaMKII binding to camR_ca1_A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_A_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca1_A </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_161" metaid="metaid_0000365" name="CaMKII binding to camR_ca1_B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca1_B </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_162" metaid="metaid_0000366" name="CaMKII binding to camR_ca1_C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca1_C </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_163" metaid="metaid_0000367" name="CaMKII binding to camR_ca1_D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca1_D </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_164" metaid="metaid_0000368" name="CaMKII binding to camR_ca2_AB" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca2_AB </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_165" metaid="metaid_0000369" name="CaMKII binding to camR_ca2_AC" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca2_AC </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_166" metaid="metaid_0000370" name="CaMKII binding to camR_ca2_AD" reversible="false">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca2_AD </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_167" metaid="metaid_0000371" name="CaMKII binding to camR_ca2_BC" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca2_BC </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_168" metaid="metaid_0000372" name="CaMKII binding to camR_ca2_BD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca2_BD </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_169" metaid="metaid_0000373" name="CaMKII binding to camR_ca2_CD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca2_CD </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_170" metaid="metaid_0000374" name="CaMKII binding to camR_ca3_ABC" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca3_ABC </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_171" metaid="metaid_0000375" name="CaMKII binding to camR_ca3_ABD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca3_ABD </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_172" metaid="metaid_0000376" name="CaMKII binding to camR_ca3_ACD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca3_ACD </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_173" metaid="metaid_0000377" name="CaMKII binding to camR_ca3_BCD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca3_BCD </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_174" metaid="metaid_0000378" name="CaMKII binding to camR_ca4_ABCD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD"/>
        <speciesReference species="CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konCaMKII </ci>
            <ci> camR_ca4_ABCD </ci>
            <ci> CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_175" metaid="metaid_0000379" name="CaMKII dissociation from camR" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_176" metaid="metaid_0000380" name="CaMKII dissociation from camR_ca1_A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_A_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca1_A_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_177" metaid="metaid_0000381" name="CaMKII dissociation from camR_ca1_B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_B_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca1_B_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_178" metaid="metaid_0000382" name="CaMKII dissociation from camR_ca1_C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_C_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca1_C_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_179" metaid="metaid_0000383" name="CaMKII dissociation from camR_ca1_D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_D_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca1_D_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_180" metaid="metaid_0000384" name="CaMKII dissociation from camR_ca2_AB" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca2_AB_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_181" metaid="metaid_0000385" name="CaMKII dissociation from camR_ca2_AC" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca2_AC_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_182" metaid="metaid_0000386" name="CaMKII dissociation from camR_ca2_AD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca2_AD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_183" metaid="metaid_0000387" name="CaMKII dissociation from camR_ca2_BC" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca2_BC_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_184" metaid="metaid_0000388" name="CaMKII dissociation from camR_ca2_BD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca2_BD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_185" metaid="metaid_0000389" name="CaMKII dissociation from camR_ca2_CD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca2_CD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_186" metaid="metaid_0000390" name="CaMKII dissociation from camR_ca3_ABC" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca3_ABC_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_187" metaid="metaid_0000391" name="CaMKII dissociation from camR_ca3_ABD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca3_ABD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_188" metaid="metaid_0000392" name="CaMKII dissociation from camR_ca3_ACD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca3_ACD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_189" metaid="metaid_0000393" name="CaMKII dissociation from camR_ca3_BCD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca3_BCD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_190" metaid="metaid_0000394" name="CaMKII dissociation from camR_ca4_ABCD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD"/>
        <speciesReference species="CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffCaMKII </ci>
            <ci> camR_ca4_ABCD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_191" metaid="metaid_0000395" name="PP2B binding to camR" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_192" metaid="metaid_0000396" name="PP2B binding to camR_ca1_A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_A_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca1_A </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_193" metaid="metaid_0000397" name="PP2B binding to camR_ca1_B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca1_B </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_194" metaid="metaid_0000398" name="PP2B binding to camR_ca1_C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca1_C </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_195" metaid="metaid_0000399" name="PP2B binding to camR_ca1_D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca1_D </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_196" metaid="metaid_0000400" name="PP2B binding to camR_ca2_AB" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca2_AB </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_197" metaid="metaid_0000401" name="PP2B binding to camR_ca2_AC" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca2_AC </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_198" metaid="metaid_0000402" name="PP2B binding to camR_ca2_AD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca2_AD </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_199" metaid="metaid_0000403" name="PP2B binding to camR_ca2_BC" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca2_BC </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_200" metaid="metaid_0000404" name="PP2B binding to camR_ca2_BD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca2_BD </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_201" metaid="metaid_0000405" name="PP2B binding to camR_ca2_CD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca2_CD </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_202" metaid="metaid_0000406" name="PP2B binding to camR_ca3_ABC" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca3_ABC </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_203" metaid="metaid_0000407" name="PP2B binding to camR_ca3_ABD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca3_ABD </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_204" metaid="metaid_0000408" name="PP2B binding to camR_ca3_ACD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca3_ACD </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_205" metaid="metaid_0000409" name="PP2B binding to camR_ca3_BCD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca3_BCD </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_206" metaid="metaid_0000410" name="PP2B binding to camR_ca4_ABCD" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD"/>
        <speciesReference species="PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> konPP2B </ci>
            <ci> camR_ca4_ABCD </ci>
            <ci> PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_207" metaid="metaid_0000411" name="PP2B dissociation from camR" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_208" metaid="metaid_0000412" name="PP2B dissociation from camR_ca1_A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_A_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_A"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca1_A_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_209" metaid="metaid_0000413" name="PP2B dissociation from camR_ca1_B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_B_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca1_B_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_210" metaid="metaid_0000414" name="PP2B dissociation from camR_ca1_C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_C_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca1_C_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_211" metaid="metaid_0000415" name="PP2B dissociation from camR_ca1_D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_D_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca1_D_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_212" metaid="metaid_0000416" name="PP2B dissociation from camR_ca2_AB" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca2_AB_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_213" metaid="metaid_0000417" name="PP2B dissociation from camR_ca2_AC" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca2_AC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_214" metaid="metaid_0000418" name="PP2B dissociation from camR_ca2_AD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca2_AD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_215" metaid="metaid_0000419" name="PP2B dissociation from camR_ca2_BC" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca2_BC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_216" metaid="metaid_0000420" name="PP2B dissociation from camR_ca2_BD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca2_BD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_217" metaid="metaid_0000421" name="PP2B dissociation from camR_ca2_CD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca2_CD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_218" metaid="metaid_0000422" name="PP2B dissociation from camR_ca3_ABC" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca3_ABC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_219" metaid="metaid_0000423" name="PP2B dissociation from camR_ca3_ABD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca3_ABD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_220" metaid="metaid_0000424" name="PP2B dissociation from camR_ca3_ACD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca3_ACD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_221" metaid="metaid_0000425" name="PP2B dissociation from camR_ca3_BCD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca3_BCD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_222" metaid="metaid_0000426" name="PP2B dissociation from camR_ca4_ABCD" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD"/>
        <speciesReference species="PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffPP2B </ci>
            <ci> camR_ca4_ABCD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_223" metaid="metaid_0000427" name="Ca binding to camR_CaMKII site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_A_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_224" metaid="metaid_0000428" name="Ca binding to camR_CaMKII site B " reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_225" metaid="metaid_0000429" name="Ca binding to camR_CaMKII site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_226" metaid="metaid_0000430" name="Ca binding to camR_CaMKII site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_227" metaid="metaid_0000431" name="Ca dissociation from camR_ca1_CaMKII site A" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca1_A_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca1_A_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_228" metaid="metaid_0000432" name="Ca dissociation from camR_ca1_CaMKII site C " reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_C_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca1_C_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_229" metaid="metaid_0000433" name="Ca dissociation from camR_ca1_CaMKII site D" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca1_D_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca1_D_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_230" metaid="metaid_0000434" name="Ca binding to camR_ca1_A_CaMKII site B" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_A_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_A_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_231" metaid="metaid_0000435" name="Ca binding to camR_ca1_A_CaMKII site C" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_A_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_A_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_232" metaid="metaid_0000436" name="Ca binding to camR_ca1_A_CaMKII site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_A_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_A_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_233" metaid="metaid_0000437" name="Ca binding to camR_ca1_B_CaMKII site A" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_B_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_B_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_234" metaid="metaid_0000438" name="Ca binding to camR_ca1_B_CaMKII site C" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_B_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_B_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_235" metaid="metaid_0000439" name="Ca binding to camR_ca1_B_CaMKII site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_B_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_B_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_236" metaid="metaid_0000440" name="Ca binding to camR_ca1_C_CaMKII site A" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_C_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_C_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_237" metaid="metaid_0000441" name="Ca binding to camR_ca1_C_CaMKII site B" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_C_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_C_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_238" metaid="metaid_0000442" name="Ca binding to camR_ca1_C_CaMKII site D" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_C_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_C_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_239" metaid="metaid_0000443" name="Ca binding to camR_ca1_D_CaMKII site A" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_D_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD_CaMKII"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_D_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_240" metaid="metaid_0000444" name="Ca binding to camR_ca1_D_CaMKII site B" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_D_CaMKII"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_BD_CaMKII"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_D_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_241" metaid="metaid_0000445" name="Ca binding to camR_ca1_D_CaMKII site C" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_D_CaMKII"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_CD_CaMKII"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_D_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_242" metaid="metaid_0000446" name="Ca dissociation from camR_ca2_AB_CaMKII site A" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AB_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_B_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca2_AB_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_243" metaid="metaid_0000447" name="Ca dissociation from camR_ca2_AB_CaMKII site B" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca2_AB_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_244" metaid="metaid_0000448" name="Ca dissociation from camR_ca2_AC_CaMKII site A" reversible="false" sboTerm="SBO:0000180">
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      <listOfProducts>
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        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca2_AC_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_245" metaid="metaid_0000449" name="Ca dissociation from camR_ca2_AC_CaMKII site C" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AC_CaMKII"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_A_CaMKII"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca2_AC_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_246" metaid="metaid_0000450" name="Ca dissociation from camR_ca2_AD_CaMKII site A" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AD_CaMKII"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_D_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca2_AD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_247" metaid="metaid_0000451" name="Ca dissociation from camR_ca2_AD_CaMKII site D" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AD_CaMKII"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_A_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca2_AD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_248" metaid="metaid_0000452" name="Ca dissociation from camR_ca2_BC_CaMKII site B" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_BC_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C_CaMKII"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca2_BC_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_249" metaid="metaid_0000453" name="Ca dissociation from camR_ca2_BC_CaMKII site C" reversible="false" sboTerm="SBO:0000180">
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      <listOfProducts>
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        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca2_BC_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_250" metaid="metaid_0000454" name="Ca dissociation from camR_ca2_BD_CaMKII site B" reversible="false" sboTerm="SBO:0000180">
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      <listOfProducts>
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        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca2_BD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_251" metaid="metaid_0000455" name="Ca dissociation from camR_ca2_BD_CaMKII site D" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca2_BD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_252" metaid="metaid_0000456" name="Ca dissociation from camR_ca2_CD_CaMKII site C" reversible="false" sboTerm="SBO:0000180">
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      <listOfProducts>
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        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca2_CD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_253" metaid="metaid_0000457" name="Ca dissociation from camR_ca2_CD_CaMKII site D" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_CD_CaMKII"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_C_CaMKII"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca2_CD_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_254" metaid="metaid_0000458" name="Ca binding to camR_ca2_AB_CaMKII site C" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca2_AB_CaMKII"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca3_ABC_CaMKII"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AB_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_255" metaid="metaid_0000459" name="Ca binding to camR_ca2_AB_CaMKII site D" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca2_AB_CaMKII"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca3_ABD_CaMKII"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AB_CaMKII </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_256" metaid="metaid_0000460" name="Ca binding to camR_ca2_AC_CaMKII site B" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca2_AC_CaMKII"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AC_CaMKII </ci>
            <ci> ca </ci>
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        </math>
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    <reaction id="reaction_257" metaid="metaid_0000461" name="Ca binding to camR_ca2_AC_CaMKII site D" reversible="false" sboTerm="SBO:0000177">
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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            <ci> camR_ca2_AC_CaMKII </ci>
            <ci> ca </ci>
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        </math>
      </kineticLaw>
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    <reaction id="reaction_258" metaid="metaid_0000462" name="Ca binding to camR_ca2_AD_CaMKII site B" reversible="false" sboTerm="SBO:0000177">
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
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        </math>
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    <reaction id="reaction_259" metaid="metaid_0000463" name="Ca binding to camR_ca2_AD_CaMKII site C" reversible="false" sboTerm="SBO:0000177">
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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            <ci> camR_ca2_AD_CaMKII </ci>
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        </math>
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    <reaction id="reaction_260" metaid="metaid_0000464" name="Ca binding to camR_ca2_BC_CaMKII site A" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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            <ci> camR_ca2_BC_CaMKII </ci>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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            <ci> camR_ca2_BC_CaMKII </ci>
            <ci> ca </ci>
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        </math>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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            <ci> camR_ca2_BD_CaMKII </ci>
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        </math>
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        <speciesReference species="ca"/>
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        <speciesReference species="camR_ca3_ACD_CaMKII"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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            <ci> camR_ca2_CD_CaMKII </ci>
            <ci> ca </ci>
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        <speciesReference species="camR_ca2_CD_CaMKII"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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            <ci> camR_ca2_CD_CaMKII </ci>
            <ci> ca </ci>
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        </math>
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        <speciesReference species="camR_ca3_ABC_CaMKII"/>
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        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca3_ABC_CaMKII </ci>
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      </kineticLaw>
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        <speciesReference species="camR_ca3_ABC_CaMKII"/>
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        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
            <ci> Spine </ci>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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            <ci> camR_ca3_BCD_CaMKII </ci>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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      <kineticLaw>
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            <times/>
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      <kineticLaw>
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            <times/>
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        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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            <ci> kon </ci>
            <ci> camR_PP2B </ci>
            <ci> ca </ci>
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        </math>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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            <ci> kon </ci>
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            <ci> ca </ci>
          </apply>
        </math>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <times/>
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            <ci> kon </ci>
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            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_289" metaid="metaid_0000493" name="Ca binding to camR_PP2B site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_D_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_290" metaid="metaid_0000494" name="Ca dissociation from camR_ca1_A_PP2B site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_A_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca1_A_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_291" metaid="metaid_0000495" name="Ca dissociation from camR_ca1_B_PP2B site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_B_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca1_B_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_292" metaid="metaid_0000496" name="Ca dissociation from camR_ca1_C_PP2B site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_C_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca1_C_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_293" metaid="metaid_0000497" name="Ca dissociation from camR_ca1_D_PP2B site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_D_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca1_D_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_294" metaid="metaid_0000498" name="Ca binding to camR_ca1_A_PP2B site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_A_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_A_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_295" metaid="metaid_0000499" name="Ca binding to camR_ca1_A_PP2B site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_A_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_A_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_296" metaid="metaid_0000500" name="Ca binding to camR_ca1_A_PP2B site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_A_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_A_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_297" metaid="metaid_0000501" name="Ca binding to camR_ca1_B_PP2B site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_B_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_B_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_298" metaid="metaid_0000502" name="Ca binding to camR_ca1_B_PP2B site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_B_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_B_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_299" metaid="metaid_0000503" name="Ca binding to camR_ca1_B_PP2B site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_B_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_B_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_300" metaid="metaid_0000504" name="Ca binding to camR_ca1_C_PP2B site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_C_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_C_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_301" metaid="metaid_0000505" name="Ca binding to camR_ca1_C_PP2B site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca1_C_PP2B"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_BC_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_C_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_302" metaid="metaid_0000506" name="Ca binding to camR_ca1_C_PP2B site D" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_C_PP2B"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_CD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_C_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_303" metaid="metaid_0000507" name="Ca binding to camR_ca1_D_PP2B site A" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_D_PP2B"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_AD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_D_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_304" metaid="metaid_0000508" name="Ca binding to camR_ca1_D_PP2B site B" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_D_PP2B"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_BD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_D_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_305" metaid="metaid_0000509" name="Ca binding to camR_ca1_D_PP2B site C" reversible="false" sboTerm="SBO:0000177">
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        <speciesReference species="camR_ca1_D_PP2B"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca2_CD_PP2B"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca1_D_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_306" metaid="metaid_0000510" name="Ca dissociating from camR_ca2_AB_PP2B site A" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AB_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_B_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca2_AB_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_307" metaid="metaid_0000511" name="Ca dissociating from camR_ca2_AB_PP2B site B " reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AB_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_A_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca2_AB_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
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    <reaction id="reaction_308" metaid="metaid_0000512" name="Ca dissociating from camR_ca2_AC_PP2B site A" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AC_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_C_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca2_AC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_309" metaid="metaid_0000513" name="Ca dissociating from camR_ca2_AC_PP2B site C" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AC_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_A_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca2_AC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_310" metaid="metaid_0000514" name="Ca dissociating from camR_ca2_AD_PP2B site A" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AD_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_D_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca2_AD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_311" metaid="metaid_0000515" name="Ca dissociating from camR_ca2_AD_PP2B site D" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_AD_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_A_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca2_AD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_312" metaid="metaid_0000516" name="Ca dissociating from camR_ca2_BC_PP2B site B" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_BC_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_C_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca2_BC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_313" metaid="metaid_0000517" name="Ca dissociating from camR_ca2_BC_PP2B site C" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_BC_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_B_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca2_BC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_314" metaid="metaid_0000518" name="Ca dissociating from camR_ca2_BD_PP2B site B" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_BD_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_D_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca2_BD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_315" metaid="metaid_0000519" name="Ca dissociating from camR_ca2_BD_PP2B site D" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_BD_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_B_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca2_BD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_316" metaid="metaid_0000520" name="Ca dissociating from camR_ca2_CD_PP2B site C" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_CD_PP2B"/>
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      <listOfProducts>
        <speciesReference species="camR_ca1_D_PP2B"/>
        <speciesReference species="ca"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca2_CD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_317" metaid="metaid_0000521" name="Ca dissociating from camR_ca2_CD_PP2B site D" reversible="false" sboTerm="SBO:0000180">
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        <speciesReference species="camR_ca2_CD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca1_C_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca2_CD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_318" metaid="metaid_0000522" name="Ca binding to camR_ca2_AB_PP2B site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AB_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_319" metaid="metaid_0000523" name="Ca binding to camR_ca2_AB_PP2B site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AB_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AB_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_320" metaid="metaid_0000524" name="Ca binding to camR_ca2_AC_PP2B site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC_PP2B"/>
        <speciesReference species="ca"/>
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      <listOfProducts>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
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      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AC_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_321" metaid="metaid_0000525" name="Ca binding to camR_ca2_AC_PP2B site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AC_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AC_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_322" metaid="metaid_0000526" name="Ca binding to camR_ca2_AD_PP2B site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AD_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_323" metaid="metaid_0000527" name="Ca binding to camR_ca2_AD_PP2B site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_AD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_AD_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_324" metaid="metaid_0000528" name="Ca binding to camR_ca2_BC_PP2B site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_BC_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_325" metaid="metaid_0000529" name="Ca binding to camR_ca2_BC_PP2B site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BC_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_BC_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_326" metaid="metaid_0000530" name="Ca binding to camR_ca2_BD_PP2B site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_BD_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_327" metaid="metaid_0000531" name="Ca binding to camR_ca2_BD_PP2B site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_BD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_BD_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_328" metaid="metaid_0000532" name="Ca binding to camR_ca2_CD_PP2B site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_CD_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_329" metaid="metaid_0000533" name="Ca binding to camR_ca2_CD_PP2B site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca2_CD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca2_CD_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_330" metaid="metaid_0000534" name="Ca dissociation from camR_ca3_ABC_PP2B site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca3_ABC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_331" metaid="metaid_0000535" name="Ca dissociation from camR_ca3_ABC_PP2B site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca3_ABC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_332" metaid="metaid_0000536" name="Ca dissociation from camR_ca3_ABC_PP2B site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca3_ABC_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_333" metaid="metaid_0000537" name="Ca dissociation from camR_ca3_ABD_PP2B site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca3_ABD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_334" metaid="metaid_0000538" name="Ca dissociation from camR_ca3_ABD_PP2B site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca3_ABD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_335" metaid="metaid_0000539" name="Ca dissociation from camR_ca3_ABD_PP2B site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AB_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca3_ABD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_336" metaid="metaid_0000540" name="Ca dissociation from camR_ca3_ACD_PP2B site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca3_ACD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_337" metaid="metaid_0000541" name="Ca dissociation from camR_ca3_ACD_PP2B site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca3_ACD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_338" metaid="metaid_0000542" name="Ca dissociation from camR_ca3_ACD_PP2B site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_AC_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca3_ACD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_339" metaid="metaid_0000543" name="Ca dissociation from camR_ca3_BCD_PP2B site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_CD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca3_BCD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_340" metaid="metaid_0000544" name="Ca dissociation from camR_ca3_BCD_PP2B site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca3_BCD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_341" metaid="metaid_0000545" name="Ca dissociation from camR_ca3_BCD_PP2B site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca2_BC_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca3_BCD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_342" metaid="metaid_0000546" name="Ca binding to camR_ca3_ABC_PP2B site D" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca3_ABC_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_343" metaid="metaid_0000547" name="Ca binding to camR_ca3_ABD_PP2B site C" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca3_ABD_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_344" metaid="metaid_0000548" name="Ca binding to camR_ca3_ACD_PP2B site B" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca3_ACD_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_345" metaid="metaid_0000549" name="Ca binding to camR_ca3_BCD_PP2B site A" reversible="false" sboTerm="SBO:0000177">
      <listOfReactants>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> kon </ci>
            <ci> camR_ca3_BCD_PP2B </ci>
            <ci> ca </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_346" metaid="metaid_0000550" name="Ca dissociating from camR_ca4_ABCD_PP2B site A" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_BCD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRA </ci>
            <ci> camR_ca4_ABCD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_347" metaid="metaid_0000551" name="Ca dissociating from camR_ca4_ABCD_PP2B site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ACD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca4_ABCD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_348" metaid="metaid_0000552" name="Ca dissociating from camR_ca4_ABCD_PP2B site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABD_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRC </ci>
            <ci> camR_ca4_ABCD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_349" metaid="metaid_0000553" name="Ca dissociating from camR_ca4_ABCD_PP2B site D" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca4_ABCD_PP2B"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_ca3_ABC_PP2B"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRD </ci>
            <ci> camR_ca4_ABCD_PP2B </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_350" metaid="metaid_0000554" name="Ca dissociation from camR_ca1_CaMKII site B" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camR_ca1_B_CaMKII"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camR_CaMKII"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffRB </ci>
            <ci> camR_ca1_B_CaMKII </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
    <reaction id="reaction_351" metaid="metaid_0000555" name="Ca dissociating from camT_ca3_ABC site C" reversible="false" sboTerm="SBO:0000180">
      <listOfReactants>
        <speciesReference species="camT_ca3_ABC"/>
      </listOfReactants>
      <listOfProducts>
        <speciesReference species="camT_ca2_AB"/>
        <speciesReference species="ca"/>
      </listOfProducts>
      <kineticLaw>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Spine </ci>
            <ci> koffTC </ci>
            <ci> camT_ca3_ABC </ci>
          </apply>
        </math>
      </kineticLaw>
    </reaction>
  </listOfReactions>
</model>
</sbml>

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