Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)

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Accession:150284
"… We present a new event-driven algorithm to synchronize different neuronal models, which decreases computational time and avoids superfluous synchronizations. The algorithm is implemented in the TimeScales framework. We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum. The model comprises over a thousand dendritic spines, where the electrical model interacts with the respective instances of a biochemical model. Our results show that a multiscale model is able to exhibit changes of synaptic plasticity as a result of the interaction between electrical and biochemical signaling. …"
Reference:
1 . Mattioni M, Le Novère N (2013) Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum. PLoS One 8:e66811 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,p; I Na,t; I T low threshold; I A; I K,Ca; I CAN; I Calcium; I A, slow; I Krp; I R; I Q;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.2 KCND2; Kv1.2 KCNA2; Cav1.3 CACNA1D; Cav1.2 CACNA1C; Kv2.1 KCNB1;
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Synaptic Plasticity; Signaling pathways; Calcium dynamics; Multiscale;
Implementer(s): Mattioni, Michele [mattioni at ebi.ac.uk];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; I Na,p; I Na,t; I T low threshold; I A; I K,Ca; I CAN; I Calcium; I A, slow; I Krp; I R; I Q;
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</value>
</value>
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_CaMKII
</value>
<value>
1
</value>
</value>
<value>
<value>
P1
</value>
<value>
Variable:/Spine:ca
</value>
<value>
1
</value>
</value>
</property>
</process>
<process class="MassActionFluxProcess" id="reaction_351">
<property name="k">
<value>
4393.93939394
</value>
</property>
<property name="StepperID">
<value>
DE1
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
S0
</value>
<value>
Variable:/Spine:camT_ca3_ABC
</value>
<value>
-1
</value>
</value>
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camT_ca2_AB
</value>
<value>
1
</value>
</value>
<value>
<value>
P1
</value>
<value>
Variable:/Spine:ca
</value>
<value>
1
</value>
</value>
</property>
</process>
<variable class="Variable" id="free_cam_ca4_total">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca4_total">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca4_ratio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca4_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca4_totalRatio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_camR_ca3_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_camT_ca3_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_cam_ca3_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="CaMKII_camR_ca3">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="PP2B_camR_ca3">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca3_total">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca3_ratio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca3_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca3_totalRatio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_camR_ca2_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_camT_ca2_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_cam_ca2_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="CaMKII_camR_ca2">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="PP2B_camR_ca2">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca2_total">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca2_ratio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca2_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca2_totalRatio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_camR_ca1_total">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_camT_ca1_total">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_cam_ca1_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="CaMKII_camR_ca1">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="PP2B_camR_ca1">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca1_total">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca1_ratio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca1_total">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca1_totalRatio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="free_cam_ca0_total">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca0_total">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_ca0_ratio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca0_total">
<property name="MolarConc">
<value>
2.000097e-07
</value>
</property>
<property name="Value">
<value>
120.4058394
</value>
</property>
</variable>
<variable class="Variable" id="cam_ca0_totalRatio">
<property name="MolarConc">
<value>
0.0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="cam_total">
<property name="MolarConc">
<value>
2.000097e-07
</value>
</property>
<property name="Value">
<value>
120.4058394
</value>
</property>
</variable>
<variable class="Variable" id="total_CaMKII_bound">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="totalCaMKII">
<property name="MolarConc">
<value>
7e-05
</value>
</property>
<property name="Value">
<value>
42140.0
</value>
</property>
</variable>
<variable class="Variable" id="CaMKIIbar">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="total_PP2B_bound">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="totalPP2B">
<property name="MolarConc">
<value>
1.6e-06
</value>
</property>
<property name="Value">
<value>
963.2
</value>
</property>
</variable>
<variable class="Variable" id="PP2Bbar">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="camR_unbound">
<property name="MolarConc">
<value>
9.7e-12
</value>
</property>
<property name="Value">
<value>
0.0058394
</value>
</property>
</variable>
<variable class="Variable" id="totalcamR">
<property name="MolarConc">
<value>
9.7e-12
</value>
</property>
<property name="Value">
<value>
0.0058394
</value>
</property>
</variable>
<variable class="Variable" id="totalcamT">
<property name="MolarConc">
<value>
2e-07
</value>
</property>
<property name="Value">
<value>
120.4
</value>
</property>
</variable>
<variable class="Variable" id="Rbar">
<property name="MolarConc">
<value>
4.84976478640786e-05
</value>
</property>
<property name="Value">
<value>
29195.5840142
</value>
</property>
</variable>
<variable class="Variable" id="moles_bound_ca_per_moles_cam">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="epsilon">
<property name="MolarConc">
<value>
4.84976478640786e-05
</value>
</property>
<property name="Value">
<value>
29195.5840142
</value>
</property>
</variable>
<variable class="Variable" id="ybar">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<variable class="Variable" id="ybar_div__1_minus_ybar">
<property name="MolarConc">
<value>
0
</value>
</property>
<property name="Value">
<value>
0.0
</value>
</property>
</variable>
<process class="PythonProcess" id="add_free_cam_ca4_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_cam_ca4_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camT_ca4_ABCD
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca4_ABCD
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca4_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca4_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca4_ABCD_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca4_ABCD_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca4_ABCD
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca4_ratio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca4_ratio
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca4_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca4_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca4_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca4_ABCD_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca4_ABCD_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camT_ca4_ABCD
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca4_ABCD
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca4_totalRatio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca4_totalRatio
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:cam_ca4_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_camR_ca3_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_camR_ca3_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca3_ABD
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca3_ACD
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca3_ABC
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca3_BCD
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_camT_ca3_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_camT_ca3_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camT_ca3_ACD
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camT_ca3_ABD
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camT_ca3_ABC
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camT_ca3_BCD
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_cam_ca3_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_cam_ca3_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:free_camT_ca3_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:free_camR_ca3_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_CaMKII_camR_ca3">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:CaMKII_camR_ca3
</value>
<value>
1
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca3_ACD_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca3_ABC_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca3_ABD_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca3_BCD_CaMKII
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_PP2B_camR_ca3">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:PP2B_camR_ca3
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca3_ABC_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca3_ACD_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca3_ABD_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca3_BCD_PP2B
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca3_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca3_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:CaMKII_camR_ca3
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:free_camR_ca3_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:PP2B_camR_ca3
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca3_ratio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca3_ratio
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca3_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca3_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca3_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:CaMKII_camR_ca3
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:PP2B_camR_ca3
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:free_cam_ca3_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca3_totalRatio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca3_totalRatio
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:cam_ca3_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_camR_ca2_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value+X5.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_camR_ca2_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca2_AD
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca2_BC
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:camR_ca2_BD
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca2_AC
</value>
<value>
0
</value>
</value>
<value>
<value>
X5
</value>
<value>
Variable:/Spine:camR_ca2_CD
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca2_AB
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_camT_ca2_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value+X5.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_camT_ca2_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camT_ca2_BC
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:camT_ca2_BD
</value>
<value>
0
</value>
</value>
<value>
<value>
X5
</value>
<value>
Variable:/Spine:camT_ca2_CD
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camT_ca2_AC
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camT_ca2_AB
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camT_ca2_AD
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_cam_ca2_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_cam_ca2_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:free_camT_ca2_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:free_camR_ca2_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_CaMKII_camR_ca2">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value+X5.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:CaMKII_camR_ca2
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca2_AB_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca2_AD_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X5
</value>
<value>
Variable:/Spine:camR_ca2_CD_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca2_BC_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:camR_ca2_BD_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca2_AC_CaMKII
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_PP2B_camR_ca2">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value+X5.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:PP2B_camR_ca2
</value>
<value>
1
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca2_AD_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:camR_ca2_BD_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X5
</value>
<value>
Variable:/Spine:camR_ca2_CD_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca2_AB_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca2_AC_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca2_BC_PP2B
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca2_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca2_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:CaMKII_camR_ca2
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:PP2B_camR_ca2
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:free_camR_ca2_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca2_ratio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca2_ratio
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca2_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca2_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca2_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:CaMKII_camR_ca2
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:PP2B_camR_ca2
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:free_cam_ca2_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca2_totalRatio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca2_totalRatio
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:cam_ca2_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_camR_ca1_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_camR_ca1_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca1_D
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca1_B
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca1_C
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca1_A
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_camT_ca1_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_camT_ca1_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camT_ca1_D
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camT_ca1_A
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camT_ca1_B
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camT_ca1_C
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_cam_ca1_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value+X5.Value+X6.Value+X7.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_cam_ca1_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca1_D
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca1_B
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca1_C
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca1_A
</value>
<value>
0
</value>
</value>
<value>
<value>
X7
</value>
<value>
Variable:/Spine:camT_ca1_D
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:camT_ca1_A
</value>
<value>
0
</value>
</value>
<value>
<value>
X5
</value>
<value>
Variable:/Spine:camT_ca1_B
</value>
<value>
0
</value>
</value>
<value>
<value>
X6
</value>
<value>
Variable:/Spine:camT_ca1_C
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_CaMKII_camR_ca1">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:CaMKII_camR_ca1
</value>
<value>
1
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca1_C_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca1_B_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca1_D_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca1_A_CaMKII
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_PP2B_camR_ca1">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:PP2B_camR_ca1
</value>
<value>
1
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca1_D_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca1_C_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca1_B_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca1_A_PP2B
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca1_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca1_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:CaMKII_camR_ca1
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:free_camR_ca1_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:PP2B_camR_ca1
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca1_ratio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca1_ratio
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca1_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca1_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca1_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:CaMKII_camR_ca1
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:PP2B_camR_ca1
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:free_cam_ca1_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca1_totalRatio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca1_totalRatio
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:cam_ca1_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_free_cam_ca0_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:free_cam_ca0_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camT
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca0_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca0_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_PP2B
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_ca0_ratio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_ca0_ratio
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_ca0_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca0_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca0_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camT
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_ca0_totalRatio">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_ca0_totalRatio
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:cam_ca0_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_cam_total">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
1
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:cam_ca3_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:cam_ca0_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:cam_ca2_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:cam_ca4_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_ca1_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_total_CaMKII_bound">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:total_CaMKII_bound
</value>
<value>
1
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:CaMKII_camR_ca2
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:CaMKII_camR_ca3
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:CaMKII_camR_ca1
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:camR_ca4_ABCD_CaMKII
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_totalCaMKII">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:totalCaMKII
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:CaMKII
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:total_CaMKII_bound
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_CaMKIIbar">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:CaMKIIbar
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:total_CaMKII_bound
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:totalCaMKII
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_total_PP2B_bound">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:total_PP2B_bound
</value>
<value>
1
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:camR_ca4_ABCD_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:PP2B_camR_ca3
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:PP2B_camR_ca2
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_PP2B
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:PP2B_camR_ca1
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_totalPP2B">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:totalPP2B
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:total_PP2B_bound
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:PP2B
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_PP2Bbar">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/X1.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:PP2Bbar
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:total_PP2B_bound
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:totalPP2B
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_camR_unbound">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value+X5.Value+X6.Value+X7.Value+X8.Value+X9.Value+X10.Value+X11.Value+X12.Value+X13.Value+X14.Value+X15.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:camR_unbound
</value>
<value>
1
</value>
</value>
<value>
<value>
X7
</value>
<value>
Variable:/Spine:camR_ca2_AD
</value>
<value>
0
</value>
</value>
<value>
<value>
X8
</value>
<value>
Variable:/Spine:camR_ca2_BC
</value>
<value>
0
</value>
</value>
<value>
<value>
X9
</value>
<value>
Variable:/Spine:camR_ca2_BD
</value>
<value>
0
</value>
</value>
<value>
<value>
X13
</value>
<value>
Variable:/Spine:camR_ca3_ACD
</value>
<value>
0
</value>
</value>
<value>
<value>
X6
</value>
<value>
Variable:/Spine:camR_ca2_AC
</value>
<value>
0
</value>
</value>
<value>
<value>
X5
</value>
<value>
Variable:/Spine:camR_ca2_AB
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:camR_ca1_D
</value>
<value>
0
</value>
</value>
<value>
<value>
X10
</value>
<value>
Variable:/Spine:camR_ca2_CD
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camR_ca1_B
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camR_ca1_C
</value>
<value>
0
</value>
</value>
<value>
<value>
X15
</value>
<value>
Variable:/Spine:camR_ca4_ABCD
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camR_ca1_A
</value>
<value>
0
</value>
</value>
<value>
<value>
X14
</value>
<value>
Variable:/Spine:camR_ca3_BCD
</value>
<value>
0
</value>
</value>
<value>
<value>
X12
</value>
<value>
Variable:/Spine:camR_ca3_ABD
</value>
<value>
0
</value>
</value>
<value>
<value>
X11
</value>
<value>
Variable:/Spine:camR_ca3_ABC
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_totalcamR">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:totalcamR
</value>
<value>
1
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:total_PP2B_bound
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:total_CaMKII_bound
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR_unbound
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_totalcamT">
<property name="FireMethod">
<value>
P0.Value=(X0.Value+X1.Value+X2.Value+X3.Value+X4.Value+X5.Value+X6.Value+X7.Value+X8.Value+X9.Value+X10.Value+X11.Value+X12.Value+X13.Value+X14.Value+X15.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:totalcamT
</value>
<value>
1
</value>
</value>
<value>
<value>
X13
</value>
<value>
Variable:/Spine:camT_ca3_ACD
</value>
<value>
0
</value>
</value>
<value>
<value>
X12
</value>
<value>
Variable:/Spine:camT_ca3_ABD
</value>
<value>
0
</value>
</value>
<value>
<value>
X11
</value>
<value>
Variable:/Spine:camT_ca3_ABC
</value>
<value>
0
</value>
</value>
<value>
<value>
X8
</value>
<value>
Variable:/Spine:camT_ca2_BC
</value>
<value>
0
</value>
</value>
<value>
<value>
X14
</value>
<value>
Variable:/Spine:camT_ca3_BCD
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camT
</value>
<value>
0
</value>
</value>
<value>
<value>
X6
</value>
<value>
Variable:/Spine:camT_ca2_AC
</value>
<value>
0
</value>
</value>
<value>
<value>
X15
</value>
<value>
Variable:/Spine:camT_ca4_ABCD
</value>
<value>
0
</value>
</value>
<value>
<value>
X9
</value>
<value>
Variable:/Spine:camT_ca2_BD
</value>
<value>
0
</value>
</value>
<value>
<value>
X10
</value>
<value>
Variable:/Spine:camT_ca2_CD
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:camT_ca1_D
</value>
<value>
0
</value>
</value>
<value>
<value>
X5
</value>
<value>
Variable:/Spine:camT_ca2_AB
</value>
<value>
0
</value>
</value>
<value>
<value>
X7
</value>
<value>
Variable:/Spine:camT_ca2_AD
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camT_ca1_A
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:camT_ca1_B
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:camT_ca1_C
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_Rbar">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/(X0.Value+X1.Value))
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:Rbar
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:totalcamR
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:totalcamT
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_moles_bound_ca_per_moles_cam">
<property name="FireMethod">
<value>
P0.Value=((((4.0)*X0.Value)+((3.0)*X1.Value)+((2.0)*X2.Value)+X3.Value)/X4.Value)
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:moles_bound_ca_per_moles_cam
</value>
<value>
1
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:cam_ca3_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X4
</value>
<value>
Variable:/Spine:cam_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X2
</value>
<value>
Variable:/Spine:cam_ca2_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:cam_ca4_total
</value>
<value>
0
</value>
</value>
<value>
<value>
X3
</value>
<value>
Variable:/Spine:cam_ca1_total
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_epsilon">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/(X0.Value+X1.Value))
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:epsilon
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:camR
</value>
<value>
0
</value>
</value>
<value>
<value>
X1
</value>
<value>
Variable:/Spine:camT
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_ybar">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/(4.0))
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:ybar
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:moles_bound_ca_per_moles_cam
</value>
<value>
0
</value>
</value>
</property>
</process>
<process class="PythonProcess" id="add_ybar_div__1_minus_ybar">
<property name="FireMethod">
<value>
P0.Value=(X0.Value/((1.0)-X0.Value))
</value>
</property>
<property name="StepperID">
<value>
Passive
</value>
</property>
<property name="VariableReferenceList">
<value>
<value>
P0
</value>
<value>
Variable:/Spine:ybar_div__1_minus_ybar
</value>
<value>
1
</value>
</value>
<value>
<value>
X0
</value>
<value>
Variable:/Spine:ybar
</value>
<value>
0
</value>
</value>
</property>
</process>
</system>
</eml>

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