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Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
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"… We present a new event-driven algorithm to synchronize different neuronal models, which decreases computational time and avoids superfluous synchronizations. The algorithm is implemented in the TimeScales framework. We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum. The model comprises over a thousand dendritic spines, where the electrical model interacts with the respective instances of a biochemical model. Our results show that a multiscale model is able to exhibit changes of synaptic plasticity as a result of the interaction between electrical and biochemical signaling. …"
Mattioni M, Le Novère N (2013) Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum.
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Neuron or other electrically excitable cell;
Neostriatum medium spiny direct pathway GABA cell;
I T low threshold;
I A, slow;
Mattioni, Michele [mattioni at ebi.ac.uk];
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Neostriatum medium spiny direct pathway GABA cell
I T low threshold
I A, slow
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