Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)

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Accession:150284
"… We present a new event-driven algorithm to synchronize different neuronal models, which decreases computational time and avoids superfluous synchronizations. The algorithm is implemented in the TimeScales framework. We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum. The model comprises over a thousand dendritic spines, where the electrical model interacts with the respective instances of a biochemical model. Our results show that a multiscale model is able to exhibit changes of synaptic plasticity as a result of the interaction between electrical and biochemical signaling. …"
Reference:
1 . Mattioni M, Le Novère N (2013) Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum. PLoS One 8:e66811 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,p; I Na,t; I T low threshold; I A; I K,Ca; I CAN; I Calcium; I A, slow; I Krp; I R; I Q;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.2 KCND2; Kv1.2 KCNA2; Cav1.3 CACNA1D; Cav1.2 CACNA1C; Kv2.1 KCNB1;
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Synaptic Plasticity; Signaling pathways; Calcium dynamics; Multiscale;
Implementer(s): Mattioni, Michele [mattioni at ebi.ac.uk];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; I Na,p; I Na,t; I T low threshold; I A; I K,Ca; I CAN; I Calcium; I A, slow; I Krp; I R; I Q;
 
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TimeScales-master
param
allspines.param
default.param
four_spines_stim.param
long_tstop.param
long_tstop_all_spines_several_stimulation.param
long_tstop_allbranch_cpm_two_branches_stims_20_Hz.param
long_tstop_allbranch_cpm_two_branches_stims_20_Hz_10_inputs.param
long_tstop_allbranch_cpm_two_branches_stims_20_Hz_20_inputs.param
long_tstop_allbranch_cpm_two_branches_stims_20_Hz_30_inputs.param
long_tstop_allbranch_cpm_two_branches_stims_20_Hz_40_inputs.param
long_tstop_allbranch_cpm_two_branches_stims_40_Hz.param
long_tstop_allbranch_cpm_two_branches_stims_40_Hz_long_train.param
long_tstop_allbranch_cpm_two_branches_stims_50_Hz.param
long_tstop_allbranch_cpm_two_branches_stims_8_Hz.param
long_tstop_allspines_1_spine_100Hz.param
long_tstop_allspines_1_spine_1Hz.param
long_tstop_allspines_1_spine_20Hz.param
long_tstop_allspines_1_spine_4Hz.param
long_tstop_allspines_1_spine_50Hz.param
long_tstop_allspines_1_spine_8Hz.param
long_tstop_double_stim_all_spines.param
long_tstop_double_stim_two_spines.param
long_tstop_one_pulse.param
long_tstop_onebranch_1_spine_100Hz.param
long_tstop_onebranch_1_spine_1Hz.param
long_tstop_onebranch_1_spine_20Hz.param
long_tstop_onebranch_1_spine_4Hz.param
long_tstop_onebranch_1_spine_50Hz.param
long_tstop_onebranch_1_spine_8Hz.param
long_tstop_onebranch_clustered_plasticity_model.param
long_tstop_onebranch_several_stimulation.param
neighbouring_spine_20Hz.param
neighbouring_spine_20Hz_all.param
neighbouring_spine_20Hz_reduced.param
short_tstop_double_stim.param
short_tstop_electrical.param
short_tstop_k_flux_investigation.param
short_tstop_onebranch_several_stimulation.param
sixteen_spines_stim.param
testrun_singlespine.param
thirtytwo_spines_stim.param
two_spines_stim.param
                            
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