ModelDB: Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)

Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)

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Citations

Accession:150284

"… We present a new event-driven algorithm to synchronize different neuronal models, which decreases computational time and avoids superfluous synchronizations. The algorithm is implemented in the TimeScales framework. We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum. The model comprises over a thousand dendritic spines, where the electrical model interacts with the respective instances of a biochemical model. Our results show that a multiscale model is able to exhibit changes of synaptic plasticity as a result of the interaction between electrical and biochemical signaling. …"
Reference:
1 . Mattioni M, Le Novère N (2013) Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum. PLoS One 8:e66811 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism:	Striatum;
Cell Type(s):	Neostriatum medium spiny direct pathway GABA cell;
Channel(s):	I Na,p; I Na,t; I T low threshold; I A; I K,Ca; I CAN; I Calcium; I A, slow; I Krp; I R; I Q;
Gap Junctions:
Receptor(s):
Gene(s):	Kv4.2 KCND2; Kv1.2 KCNA2; Cav1.3 CACNA1D; Cav1.2 CACNA1C; Kv2.1 KCNB1;
Transmitter(s):
Simulation Environment:	NEURON; Python;
Model Concept(s):	Synaptic Plasticity; Signaling pathways; Calcium dynamics; Multiscale;
Implementer(s):	Mattioni, Michele [mattioni at ebi.ac.uk];