Calcium waves and mGluR-dependent synaptic plasticity in CA1 pyr. neurons (Ashhad & Narayanan 2013)

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Accession:150551
A morphologically realistic, conductance-based model equipped with kinetic schemes that govern several calcium signalling modules and pathways in CA1 pyramidal neurons
Reference:
1 . Ashhad S, Narayanan R (2013) Quantitative interactions between the A-type K+ current and inositol trisphosphate receptors regulate intraneuronal Ca2+ waves and synaptic plasticity. J Physiol 591:1645-69 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; Ca pump;
Gap Junctions:
Receptor(s): AMPA; NMDA; mGluR; IP3;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Synaptic Plasticity; Signaling pathways; Calcium dynamics; G-protein coupled; Calcium waves;
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in]; Ashhad, Sufyan [soofy at mbu.iisc.ernet.in];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; mGluR; IP3; I Na,t; I L high threshold; I T low threshold; I A; I K; Ca pump; Glutamate;
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AshhadNarayanan2013
Readme.html
cal4.mod
Calamp.mod
caltype.mod
camax.mod
cat.mod
ghknmda.mod
ip3dif.mod
kadist.mod *
kaprox.mod *
kdrca1.mod
mglur.mod
na3.mod
nax.mod *
Wghkampa.mod
CalciumWave.hoc
distance.hoc
Fig4F-G.hoc
Fig6C-F.hoc
mosinit.hoc
n123.hoc
n123_all.dis
n123_all.rdis
ObliquePath.hoc
oblique-paths.hoc
parameters.hoc
screenshot4F.png
screenshot4G.png
screenshot6C-F.png
                            
load_file("nrngui.hoc")
load_file("CalciumWave.hoc")
forall{
	ip3i0=  0.16e-3  //  baseline value
	ip3i0_ip3dif=ip3i0
    }
tstop=90020
steps_per_ms = 20
dt = 0.05
AddSynapse()

/**********************************************************************/




objectvar g[20]         // max 20 graphs
ngraph = 0

proc addgraph() {  // define subroutine to add a new graph
                // addgraph("variable", minvalue, maxvalue)
    ngraph = ngraph+1
    ii = ngraph-1
    g[ii] = new Graph()
    g[ii].size(0,tstop,$2,$3)
    g[ii].xaxis()
    g[ii].yaxis()
    g[ii].addvar($s1,1,0)
    g[ii].save_name("graphList[0].")
    graphList[0].append(g[ii])
}

if(ismenu==0) {
  nrnmainmenu()         // create main menu
  nrncontrolmenu()      // create control menu
  ismenu=1


addgraph("apical[112].ip3i (0.5)",0.16e-3,4e-3)
addgraph("apical[112].cai (0.5)",5e-5,0.8e-3)
addgraph("apical[112].jip3_cal4 (0.5)",0,2e-5)
addgraph("ampa[0].w",0,1)



}


 

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