CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)

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The paper discusses the effects induced by an electric field at power lines frequency.
1 . Cavarretta F, Carnevale NT, Tegolo D, Migliore M (2014) Effects of low frequency electric fields on synaptic integration in hippocampal CA1 pyramidal neurons: implications for power line emissions. Front Cell Neurosci 8:310 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Extracellular;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA;
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Extracellular Fields;
Implementer(s): Carnevale, Ted [Ted.Carnevale at]; Migliore, Michele [Michele.Migliore at]; Cavarretta, Francesco [francescocavarretta at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I h; Glutamate;
fzap.mod *
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3n.mod *
naxn.mod *
netstimm.mod *
xtrau.mod *
anatscale.hoc *
efheader.hoc *
geo5038804.hoc *
interpxyzu.hoc *
mosinit.hoc *
setnseg.hoc *
setpointersu.hoc *
// zapstimu.hoc, based on zapstim.hoc
/* The stimulus is generated by an instance of the Fzap class 
(a point process that produces a sine wave of user-specified duration and
amplitude, that sweeps over a range of frequencies at a constant rate).
For each section that has the xtra mechanism, this waveform 
is used to drive is_xtra.
The transfer resistance rx_xtra takes care of the 
amplitude and sign of the local extracellular field.

// default values
DEL = 2000  // ms
DUR = 4000  // ms
F0 = 50  // Hz
F1 = 50 // Hz
// AMP = 1  // nA
AMP = 500  // V/m

objref fz
fz = new Fzap(0.5)
// setpointer fz.x, is_xtra(0.5)
// setpointer fz.x, is_xtra
setpointer fz.x, E_xtrau

proc setstim() {
  fz.del = $1
  fz.dur = $2
  fz.f0 = $3
  fz.f1 = $4
  fz.amp = $5

setstim(DEL, DUR, F0, F1, AMP)

print "Use setstim(DEL, DUR, F0, F1, AMP) to change latency (ms), duration (ms),"
print "start and end frequency (Hz), and amplitude (V/m) of applied electrical field."
xpanel("Applied Electrical Field", 0)
  xvalue("del (ms)", "DEL", 1, "setstim(DEL,DUR,F0,F1,AMP)", 0, 1)
  xvalue("dur (ms)", "DUR", 1, "setstim(DEL,DUR,F0,F1,AMP)", 0, 1)
  xvalue("start f (Hz)", "F0", 1, "setstim(DEL,DUR,F0,F1,AMP)", 0, 1)
  xvalue("end f (Hz)", "F1", 1, "setstim(DEL,DUR,F0,F1,AMP)", 0, 1)
  xvalue("amp (V/m)", "AMP", 1, "setstim(DEL,DUR,F0,F1,AMP)", 0, 1)

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