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Model of repetitive firing in Grueneberg ganglion olfactory neurons (Liu et al., 2012)
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This model is constructed based on properties of Na+ and K+ currents observed in whole-cell patch clamp recordings of mouse Grueneberg ganglion neurons in acute slices. Two distinct Na+ conductances representing the TTX-sensitive and TTX-resistant currents and one delayed rectifier K+ currrent are included. By modulating the maximal conductances of Na+ currents, one can reproduce the regular, phasic, and sporadic patterns of repetitive firing found in the patch clamp experiments.
Liu CY, Xiao C, Fraser SE, Lester HA, Koos DS (2012) Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents.
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Neuron or other electrically excitable cell;
Olfactory receptor GLU cell;
Grueneberg ganglion neuron;
Action Potential Initiation;
Temporal Pattern Generation;
Liu, Cambrian [camliu at chla.usc.edu];
for information about:
Olfactory receptor GLU cell
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